What is the cytotoxin causing necrotising fasciitis? What organism?
Panton Valentine Leukocidin (PVL)
Produced by virulent Staphlococcus Aureus (MRSA)
What does the virulence factor Adhesin do
Enables binding of the organism to host tissue
What does the virulence factor Invasin do
Enables the organism to invade host tissue
What does the virulence factor Impedin do
enables the organism to avoid host defense mechanism
What does the virulence factor Aggressin do
Causes damage to host directly
What does the virulence factor Modulin do
Induces damage to host indirectly
What is Erythropoietic protoporphyria
Disease presented in early childhood with discomfort, itch or tingling in sun exposed skin but other there are no clinical signs. It is caused by a build-up of protoporphyrin IX due to lack of the enzyme ferrochelatase.
What is porphyria cutanea tarda
Disease presented usually in iddle age with blistering, scarring and milia formation of dorsal hands/forearm and often hypertrichosis (excess hair). It is caused by a deficiency of the enzyme Uroporphyrinogen decarboxylase and can be associated with liver disease. Ex Alcoholics
What is a sign of Neurofibromatosis Type 1
Cafe au lait macules, 90% cases
Describe Plaque
Palpable flat lesion, >1cm. Raised or not
Describe Bulla
Fluid-filled blister, >1cm, Single compartment of multiloculated
Describe Papule
Small Palbable lesion, <1cm, Raised, solitary or multiple
Describe Pustule
Pus filled, white or yellow
Describe Nodule
A enlarged papule in three dimensions, >1cm, Solid
Describe Wheal
Oedematous papule or plaque caused by swelling in the dermis
Describe Vesicle (dermatology skin lesion)
Small fluid filled blister, <1cm, single or multiple, clear or blood strained
Describe Macule
Small area of color change <1.5cm, smooth surface
Describe Maceration
Moist peeling skin
What organism usually cause impetigo
Staph. Aureus
Tinea capitis affect the
Scalp
Tinea barbae affect the
Beard
Tinea corporis affect the
Body
Tinea manuum affect the
Hand
Tinea unguium affect the
Nails
