Babbling, pointing, gesturing
12m at the latest
Single words
16m at the latest
> 10 words
20m at the latest
Two-word spont phrases
24m at the latest
> 50 words/2 word combinations
30m at the latest
Strongest predictor of ASD prognosis
level of verbal communication and IQ before 5yo
- functional communication
Worse prognosis of ASD when 8-10yo at 3-5yo
3-5 yo more severe preoccupation with parts of objects, sensory interets and stereotyped motor movements –> less developed cognitive and adaptive skills/greater severity
MRI showing parieto-occipital region white matter change and internal capsule on FLAIR sequence
X linked ALD (VLCFA), males, 4-8yo