DRUG INTERACTIONS

Question 1

WARFARIN INTERACTIONS

Answer 1

THE S ISOMER IS A SUBSTRATE OF CYP2C9

Question 2

WHICH STATINs HAS THE LOWEST POTENTIAL FOR DDI?

Answer 2

PRAVASTATIN AND ROSUVASTATIN ARE NOT METABOLIZED BY CYP3A4

Question 3

COMMON CYP INHIBITORS

Answer 3

G-PACMAN
GRAPEFRUIT
PROTEASE INHIBITORS
AZOLE ANTIFUNGALS
CYCLOSPORINE, COBICISTAT
MACROLIDES
AMIODARONE
NON-DHP CCBS

Question 4

COMMON CYP INDUCERS

Answer 4

PS PORCS
PHENYTOIN
SMOKING
PHENOBARBITAL
OXCARBAZEPINE
RIFAMPIN
CARBAMAZEPINE (ALSO AUTOINDUCER)
ST JOHNS WORT

Question 5

PGP INHIBITORS

Answer 5

ANTIINFECTIVES: CLARITHROMYCIN, ITRACONAZOLE
CV DRUGS: AMIODARONE, DILTIAZEM, VERAPAMIL
HIV DRUGS: COBICISTAT, RITONAVIR
HCV DRUGS
OTHERS: CYCLOSPORINE