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Flashcards in Drugs Deck (15)
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1

CYP3A

Substrates: Cyclosporine mechanism: genetically less important than other drug metabolism genes b/c activity continuous and unimodal

2

Ketoconazole, grapefruit juice inhibit....

CYP3A

3

Rifampin induces...

CYP3A

4

CYP2D6

Substrates: Tricyclic antidepressants and codeine (activates codeine->morphine)

5

Quinidine, Fluoxetine, Paroxetine inhibit...

CYP2D6

6

CYP2C9

Substrates: Warfarin

7

20% of caucasians need lower dose of ..... because they are poor metabolizers

Warfarin

8

NAT

Modifies risk of cancers though differences in acetylation of carcinogens, Important in Phase II pathway

9

Isoniazid for TB mechanism

Acts on NAT

10

TMPT

5% of kids with ALL (leukemia) poor metabolizers (absent activity)--> will KILL child (immunosuppression) if don't test for it (functional assay)

11

6-mercaptopurine, 6-thioguanine

Acts on TMPT

12

G6PD

X-linked enzyme -Deficient individuals susceptible to hemolytic anemia after sulfa or dapsone drug exposures

13

Sulfonamide antibiotics, dapsone are substrates for...

G6PD

14

VKORC1

VKORC1 reduces vitamin K so that vitamin K can be recycled and used to make more coagulation factors

15

Warfarin acts on...

VKORC1