etiology of UTIs
E.coli (80-90%)
Other G-s (common in hospital, nursing home, immuen compromised, GU cath): proteus, klebsiella, pseudomonas
G+s: staph sapro, staph a., group B strep, enterococcus
renal parenchyma infection
pylenephritis
other causes of dysuria
menopausal: vaginal atrophy d/t loss of estrogen
fever
flank pain
CVA tenderness
nausea, vomiting
upper tract UTI
vaginal discharge
perineal pruritus
dysuria
reproductive age
vaginitis
if women has: nocturia cloudy smelly urine urinary frequency or urgency dysuria suprapubic discomfort
high confidence that it is a lower UTI
dysuria urgency with decreased urine flow tender and boggy prostate hesitancy \+/- fever
prostatisis
high risk groups for UTI
- uropathogens colonize vagina (d/t diaphgram, sponge, jelly)
complicated infection red flags
male infant, geriatric sx > 7 days immunosuppresed acute pyelonephritis in last year anatomic abnormality DM fever flank pain or tenderness
no fever or flank pain does/doesn’t eliminate possiblity of UTI
doesn’t
called occult pyelonephritis (just like lower UTI)
dipstick portion of a UA
blood nitrite (50% UTIs, high FN rate, converted by bacteria over several hrs, except G+s and pseudomonas, if vegetarian won't have nitrates to convert) luekocyte esterase (75% UTIs, WBCs, high FP rate)
dipstick results for a UTI
positive: either nitrite or LE positive
negative: both negative
dipstick shows blood
rule in UTI (but FP: myoglobin, bacteria producing peroxidase)
microscopy portion of UA
WBC count (women >2, men>5, kids >10)
RBC count
bacteria (if >10)
white cell casts
standard for UTI diagnosis
positive urine culture: >100 cfu of bacteria
use of urine culture only if
kid, men, older women, recurrent UTI in women
if healthy women: lack of prediction of response to Abx with culture
treatment of
acute uncomplicated lower UTI in healthy women
self-limited in 1 week: 40% but still treat with 3 days of Abx: TMP/SMX, TMX, nitrofurantoin (need 7 days), FQ (ciprofloxacin)
treatment of occult pyelonephritis
7 days of TMP/SMX or FQ
management of recurrent UTIs is women
don’t need radiographic or urologic evaliuation
women with recurrent infections: behavior modifications (front to back, postcoital voiding, no pantyhose)
do not prevent UTIs
acute pyelonephritis in young women who is medically stable who maintains oral hydration
treat OP
acute pyelonephritis in hospitalized women (sepsis, abscess)
test of cure for pyelonephritis
urine culture 2-4 wks after end of Abx
man with lower UTI or pyelonephritis
- 7-10 days FQ if UTI or 14 days if pyelonephritis