Endocrine

Question 1

Danger Signals

(5)

Answer 1

HYPOGLYCEMIA

TYPE 1 DIABETES MELLITUS

THYROID CANCER

PHEOCROMOCYTOMA

HYPERPROLACTINEMIA

Question 2

Hypoglycemia

Hypoglycemia refers to blood glucose that is

Patient complains of ____ness, hand _____, and anxiety and feels like p_____ out. Difficulty concentrating. More common in people with type __ diabetes mellitus (DM; only 5%–10% of DM is type 1, average of two episodes per week). If severe hypoglycemia is uncorrected, it will progress to ___.

Answer 2

Hypoglycemia refers to blood glucose that is <50 mg/dL.

Patient complains of weakness, hand tremors, and anxiety and feels like passing out. Difficulty concentrating. More common in people with type 1 diabetes mellitus (DM; only 5%–10% of DM is type 1, average of two episodes per week). If severe hypoglycemia is uncorrected, it will progress to coma.

Question 3

Hypoglycemia

Nondiabetic hypoglycemia is rare and is either reactive (diet related) or fasting (disease related).

For diabetic individuals, the American Diabetes Association (ADA) defines

1. Level 1 hypoglycemia (glucose alert) as fasting blood sugar (FBS) of ≤___ mg/dL.
2. Level 2 hypoglycemia is blood glucose of ≤___ mg/dL. A blood glucose of this level is sufficiently low to indicate serious, clinically important hypoglycemia.

Answer 3

Nondiabetic hypoglycemia is rare and is either reactive (diet related) or fasting (disease related).

For diabetic individuals, the American Diabetes Association (ADA) defines

1. Level 1 hypoglycemia (glucose alert) as fasting blood sugar (FBS) of ≤70 mg/dL.
2. Level 2 hypoglycemia is blood glucose of ≤54 mg/dL. A blood glucose of this level is sufficiently low to indicate serious, clinically important hypoglycemia.

Question 4

Type 1 Diabetes Mellitus

School-age child with recent onset of persistent thirst (______) with frequent urination (_____) and weight ____. Feeling of hunger even though eating an increased amount of food; weight loss. May be accompanied by _____ vision (osmotic effect on the lens). Breath has a “____” odor. Large number of _____in urine.

Children may present with diabetic _______ (DKA) and neurologic symptoms, such as drowsiness and leth____, which can progress to ____. May report a recent viral-like illness before the onset of symptoms. Diagnosis peaks from ages __ to __ years and again from ages __ to __ years.

Answer 4

School-age child with recent onset of persistent thirst (polydipsia) with frequent urination (polyuria) and weight loss. Feeling of hunger even though eating an increased amount of food; weight loss. May be accompanied by blurred vision (osmotic effect on the lens). Breath has a “fruity” odor. Large number of ketones in urine.

Children may present with diabetic ketoacidosis (DKA) and neurologic symptoms, such as drowsiness and lethargy, which can progress to coma. May report a recent viral-like illness before the onset of symptoms. Diagnosis peaks from ages 4 to 6 years and again from ages 10 to 14 years.

Question 5

Thyroid Cancer

A single thyroid nodule, usually located on the ____ half of one lobe in a patient, may be accompanied by enlarged _____ lymph node lump, swelling, or pain. May complain of h____ness and problems with sw______ (dysphagia, dyspnea, or cough).

• Higher incidence in the ____ race. ______ therapy during childhood for certain cancers (Wilms’s tumor, lymphoma, neuroblastoma) and/or a low-iodine diet increases risk.
• Higher prevalence in what gender (1) (3:1).
• Highest incidence from age__ to __ years. Positive _____ history of thyroid cancer. Metastasis is by ____ route.

Answer 5

A single thyroid nodule, usually located on the upper half of one lobe in a patient, may be accompanied by enlarged cervical lymph node lump, swelling, or pain. May complain of hoarseness and problems with swallowing (dysphagia, dyspnea, or cough).

• Higher incidence in the Asian race. Radiation therapy during childhood for certain cancers (Wilms’s tumor, lymphoma, neuroblastoma) and/or a low-iodine diet increases risk.
• Higher prevalence in women (3:1).
• Highest incidence from age 20 to 55 years. Positive family history of thyroid cancer. Metastasis is by lymph route.

Question 6

Pheochromocytoma

=

• It generally occurs in persons aged __ to __ years but can appear at any age.
• Random episodes of ____ache (can be mild to severe), dia______, and _____ cardia accompanied by (1).
• Episodes resolve _________. In between attacks, patient’s vital signs are normal.

Answer 6

A pheochromocytoma is a rare hormone-releasing adrenal tumor.

• It generally occurs in persons aged 20 to 50 years but can appear at any age.
• Random episodes of headache (can be mild to severe), diaphoresis, and tachycardia accompanied by hypertension.
• Episodes resolve spontaneously. In between attacks, patient’s vital signs are normal.

Question 7

Pheochromocytoma Triggers

• Physical ex______, anx____, str____, surgery, anesthesia, changes in body _____, or labor and delivery.
• Foods high in ______ (some cheeses, beers, wines, chocolates, dried or smoked meats)
• (1) drug class and st______ drugs are other triggers.

Answer 7

• Physical exertion, anxiety, stress, surgery, anesthesia, changes in body position, or labor and delivery.
• Foods high in tyramine (some cheeses, beers, wines, chocolates, dried or smoked meats)
• Monoamine oxidase inhibitors (MAOIs) and stimulant drugs are other triggers.

Question 8

Hyperprolactinemia

Can be a sign of a ______ adenoma.

Serum prolactin is elevated

• _____ onset.
• Women may present with ______.
• _______ in both males and females.
• When the tumor is large enough to cause a ____ effect, the patient will complain of (2)

Answer 8

Can be a sign of a pituitary adenoma.

Serum prolactin is elevated.

• Slow onset.
• Women may present with amenorrhea.
• Galactorrhea in both males and females.
• When the tumor is large enough to cause a mass effect, the patient will complain of headaches and vision changes.

Question 9

Normal Findings

The endocrine system works as a “_______feedback” system. If a ____ level of “_____” hormones occurs, it stimulates production. Inversely, if the level of hormones is high, it _____ production.

1. (1) stimulates the
2. (1) into producing the “_______ hormones” (such as follicle-stimulating hormone [FSH], luteinizing hormone [LH], thyroid-stimulating hormone [or thyrotropin; TSH]). These stimulating hormones tell the
3. (1) (e.g., ovaries, thyroid) to produce “_____” hormones (e.g., estrogen, thyroid hormone).

High levels of these “active” hormones work in reverse. The hypothalamus directs the anterior pituitary into stopping production of the stimulating hormones (e.g., TSH, LH, FSH).

Answer 9

The endocrine system works as a “negative feedback” system. If a low level of “active” hormones occurs, it stimulates production. Inversely, if the level of hormones is high, it stops production.

1. Hypothalamus stimulates the
2. Anterior pituitary gland into producing the “stimulating hormones” (such as follicle-stimulating hormone [FSH], luteinizing hormone [LH], thyroid-stimulating hormone [or thyrotropin; TSH]). These stimulating hormones tell the
3. Target organs (e.g., ovaries, thyroid) to produce “active” hormones (e.g., estrogen, thyroid hormone).

High levels of these “active” hormones work in reverse. The hypothalamus directs the anterior pituitary into stopping production of the stimulating hormones (e.g., TSH, LH, FSH).

Question 10

Hypothalamus Releasing Hormones

(5)

Answer 10

1. Thyroid Releasing Hormone (TRH)
2. Gonadotropin Releasing Hormone (GnRH)
3. Corticotropin Releasing Hormone (CRH)
4. Growth Hormone Releasing Hormone (GHRH)
5. Somatostatin

Somatostatin inhibits release of GH from pituitary gland

Question 11

Anterior Pituitary Stimulating Hormones

(7)

Answer 11

1. Thyroid Stimulating Hormone (TSH)
2. Follicle Stimulating Hormone (FSH)
3. Luteinizing Hormone (LH)
4. Growth Hormone (GH)
5. Adrenocorticotropic Hormone (ACTH)
6. Melanocyte Stimulating Hormone (MSH)
7. Prolactin

Question 12

Posterior Pituitary Stimulating Hormones

(2)

Answer 12

Antidiuretic Hormones (ADH)

Oxytocin

Question 13

Target Organs and Effects

1. Thyroid (TSH) =
2. Ovaries/Testes (FSH/LH) =
3. Adrenal Cortex (ACTH) =
4. Body (GH) =
5. Uterus (Oxytocin) =
6. Kidneys (Vasopressin (ADH)) =
7. Pineal (melatonin) =
8. Breast (Prolactin) =

Answer 13

1. Thyroid (TSH) = T3 and T4
2. Ovaries/Testes (FSH/LH) = Estrogen, Progesterone, Androgens, Testosterone
3. Adrenal Cortex (ACTH) = Glucocorticoids, Mineralcorticoids
4. Body (GH) = Somatic growth
5. Uterus (Oxytocin) = Uterine contractions, bonding
6. Kidneys (Vasopressin (ADH)) = Blood volume
7. Pineal (melatonin) = Circadian rhythm
8. Breast (Prolactin) = Milk production

Question 14

Endocrine Glands

These glands form the (1) axis

Hypothalamus

Coordinates the n____ and end______ system by sending signals via the ______ gland. The gland interacts to form the HPA axis. Produces neurohormones that stimulate or stop production of pituitary hormones.

Pituitary Gland

Located at the sella turcica (_____of the brain). Stimulated by the hypothalamus into producing the ______ hormones such as FSH, LH, TSH, adrenocorticotropic hormone (ACTH), and growth hormone (GH).

Answer 14

These glands form the Hypothalamic-Pituitary-Adrenal (HPA) axis

Hypothalamus

Coordinates the nervous and endocrine system by sending signals via the pituitary gland. The gland interacts to form the HPA axis. Produces neurohormones that stimulate or stop production of pituitary hormones.

Pituitary Gland

Located at the sella turcica (base of the brain). Stimulated by the hypothalamus into producing the stimulating hormones such as FSH, LH, TSH, adrenocorticotropic hormone (ACTH), and growth hormone (GH).

Question 15

Anterior Pituitary Gland (Adenohypophysis)

It has two lobes (anterior and posterior). The _____ pituitary gland produces hormones that directly regulate the target ____ (e.g., ovaries, testes, thyroid, adrenals).

Answer 15

It has two lobes (anterior and posterior). The anterior pituitary gland produces hormones that directly regulate the target organs (e.g., ovaries, testes, thyroid, adrenals).

Question 16

FSH:

• Stimulates the ______ to enable growth of follicles (or ____)
• Production of _______

LH:

• Stimulates the ovaries to ______
• Production of _______ (by corpus luteum)
• In males, LH stimulates the testicles (____cells) to produce ______

Answer 16

FSH:

• Stimulates the ovaries to enable growth of follicles (or eggs)
• Production of estrogen

LH:

• Stimulates the ovaries to ovulate
• Production of progesterone (by corpus luteum)
• In males, LH stimulates the testicles (Leydig cells) to produce testosterone

Question 17

TSH:

• Stimulates ____ gland
• Production of _______ (T3) and _____ (T4)
• GH*:
• Stimulates (1) of the body

Answer 17

TSH:

• Stimulates thyroid gland
• Production of triiodothyronine (T3) and thyroxine (T4)
• GH*:
• Stimulates somatic growth of the body

Question 18

ACTH:

• Stimulates the ______ glands (two portions of gland: _____ and _____)
• Production of glucocorticoids (_____) and mineralocorticoids (______)

Answer 18

• Stimulates the adrenal glands (two portions of gland: medulla and cortex)
• Production of glucocorticoids (cortisol) and mineralocorticoids (aldosterone)

Question 19

• Prolactin:*
• Affects lactation and ____ production
• Melanocyte-stimulating hormone:*
• Production of ______ in response to UV light; highest levels at night between __ p.m. and __ a.m.

Answer 19

• Prolactin:*
• Affects lactation and milk production
• Melanocyte-stimulating hormone:*
• Production of melatonin in response to UV light; highest levels at night between 11 p.m. and 3 a.m.

Question 20

Posterior Pituitary Gland

Secretes ________ hormone (vasopressin) and _____, which are made by the hypothalamus but st____ and sec______ by the posterior pituitary.

Answer 20

Secretes antidiuretic hormone (vasopressin) and oxytocin, which are made by the hypothalamus but stored and secreted by the posterior pituitary.

Question 21

Thyroid Gland

A butterfly-shaped organ (two lobes) located below the prominence of the thyroid _____(Adam’s apple). It is __inches long, and the lobes are connected by the _____. Uses _____to produce T3 and T4.

Answer 21

A butterfly-shaped organ (two lobes) located below the prominence of the thyroid cartilage (Adam’s apple). It is 2 inches long, and the lobes are connected by the isthmus. Uses iodine to produce T3 and T4.

Question 22

Parathyroid Glands

Located _____ the thyroid glands (two glands behind each lobe). Produces (1) hormone, which is responsible for the _____ balance of the body by regulating the calcium loss or gain from the b____, k_____, and G______ tract (calcium absorption).

Answer 22

Located behind the thyroid glands (two glands behind each lobe). Produces parathyroid hormone (PTH), which is responsible for the calcium balance of the body by regulating the calcium loss or gain from the bones, kidneys, and gastrointestinal (GI) tract (calcium absorption).

Question 23

Pineal Gland

Pea-sized gland located inside the ____ that produces _____. Melatonin regulates the sleep–wake cycle. _____ stimulates melatonin production, and ____ suppresses it.

Answer 23

Pea-sized gland located inside the brain that produces melatonin. Melatonin regulates the sleep–wake cycle. Darkness stimulates melatonin production, and light suppresses it.

Question 24

Thyroid Gland Tests

• (1)* Used to detect goiter (generalized enlargement of gland), multinodular goiter, single nodule, and solid versus cystic masses
• (1):* Used as a diagnostic test for thyroid cancer
• (1):* Shows metabolic activity of thyroid gland

Answer 24

• Thyroid gland ultrasound:* Used to detect goiter (generalized enlargement of gland), multinodular goiter, single nodule, and solid versus cystic masses
• Fine-needle biopsy:* Used as a diagnostic test for thyroid cancer
• Thyroid scan (24-hour thyroid scan with RAIU):* Shows metabolic activity of thyroid gland
• RAIU = Radioactive iodine uptake test*

Question 25

Laboratory Findings of Thyroid Disease * *\_\_\_\_\_ spot:* Not metabolically active (more worrisome; rule out thyroid cancer); next step is to do? * *\_\_\_\_ spot:* Metabolically active nodule with homogeneous uptake; usually benign; helpful in diagnosing recurrent disease

Answer 25

* *Cold spot:* Not metabolically active (more worrisome; rule out thyroid cancer); fine-needle aspiration biopsy * *Hot spot:* Metabolically active nodule with homogeneous uptake; usually benign; helpful in diagnosing recurrent disease

Question 26

*TSH (thyroid-stimulating hormone or thyrotropin):* * Normal range: TSH of ____ to ____ mU/L (third-generation test). * TSH is used for both screening and monitoring response to treatment. * Recheck TSH every ___ to __ weeks. Dose of levothyroxine (Synthroid) is based on the TSH level. Goal is a TSH __ 5.0 mU/L. * When TSH is stable, recheck every __ to __ months.

Answer 26

* Normal range: TSH of 0.5 to 5.0 mU/L (third-generation test). * TSH is used for both screening and monitoring response to treatment. * – Recheck TSH every 6 to 8 weeks. Dose of levothyroxine (Synthroid) is based on the TSH level. Goal is a TSH \<5.0 mU/L. * – When TSH is stable, recheck every 6 to 12 months.

Question 27

What Thyroid Disorder do these labs show? * TSH \> 5.0 * Free T4 = Low * T3 = Low

Answer 27

Hypothyroidism

Question 28

What Thyroid Disorder do these labs show? * TSH \< 0.05 * Free T4 High * T3 High

Answer 28

Hyperthyroidism

Question 29

What Thyroid Disorder do these labs show? * TSH \>5.0 * Free T4 Normal * T3 Normal

Answer 29

Subclinicial Hypothyroidism

Question 30

What Thyroid Disorder do these labs show? * TSH \<0.05 * Free T4 Normal * T3 Normal

Answer 30

Subclinical Hyperthyroidism

Question 31

Primary Hyperthyroidism (Thyrotoxicosis) **(1) Disease =** The classic finding is a very ____ (or undetectable) TSH with _______ in both serum-free T4 and T3 levels.

Answer 31

**Graves Disease** Chronic autoimmune disorder that is the most common cause for hyperthyroidism (60%–80%) in the United States The classic finding is a very low (or undetectable) TSH with elevations in both serum-free T4 and T3 levels.

Question 32

Graves’ Disease Graves’ disease accounts for \_\_% to \_\_% of all types of hyperthyroidism. An ________ disorder causing hyperfunction and production of ______ thyroid hormones (T3 and T4). * Higher incidence in what gender? (7:1 ratio). * These women are also at higher risk for other autoimmune diseases such as rheumatoid arthritis (RA) and pernicious anemia (PA) and for osteopenia/osteoporosis due to increased metabolism.

Answer 32

Graves’ disease accounts for 60% to 80% of all types of hyperthyroidism. An autoimmune disorder causing hyperfunction and production of excess thyroid hormones (T3 and T4). * Higher incidence in women (7:1 ratio). * These women are also at higher risk for other _____ diseases such as (1) and (1) and for \_\_\_\_penia/porosis due to increased metabolism.

Question 33

Classic Case of Graves Disease \_\_\_\_\_\_-aged woman ____ a large amount of weight rapidly with anxiety and insomnia. Cardiac symptoms (due to overstimulation) are pal\_\_\_\_\_, hypertension, atrial \_\_\_\_\_\_, or premature atrial contractions. W\_\_\_\_ and m\_\_\_\_\_\_ skin with increased pers\_\_\_\_\_\_. May present with ________ and lid lag (Graves’ ophthalmopathy). More ______ bowel movements (looser stools). \_\_\_\_orrhea and (1) temperature intolerance. Enlarged thyroid (g\_\_\_\_\_) and/or thyroid nod\_\_\_\_\_\_ present. May be accompanied by pretibial myx\_\_\_\_\_ (thickening of the skin usually located in the shins and gives an orange-peel appearance).

Answer 33

Middle-aged woman loses a large amount of weight rapidly with anxiety and insomnia. Cardiac symptoms (due to overstimulation) are palpitations, hypertension, atrial fibrillation, or premature atrial contractions. Warm and moist skin with increased perspiration. May present with ophthalmopathy and lid lag (Graves’ ophthalmopathy). More frequent bowel movements (looser stools). Amenorrhea and heat intolerance. Enlarged thyroid (goiter) and/or thyroid nodules present. May be accompanied by pretibial myxedema (thickening of the skin usually located in the shins and gives an orange-peel appearance).

Question 34

Objective Findings of Graves Disease * *Thyroid:* ______ enlarged gland (goiter), toxic ad\_\_\_\_\_, or multi\_\_\_\_\_\_r goiter. May be tender to palpation or asymptomatic * *Extremities:* Fine _____ on both hands, _____ palms, pretibial \_\_\_\_\_\_ * *Eyes:* Lid \_\_\_; \_\_\_\_\_\_\_\_in one or both eyes * *Cardiac:* \_\_\_\_\_\_cardia, atrial \_\_\_\_\_\_, congestive heart failure, cardiomyopathy * *Integumentary:* ____ hair, _____ skin * *Neurologic:* _____ deep tendon reflexes

Answer 34

* *Thyroid:* Diffusely enlarged gland (goiter), toxic adenoma, or multinodular goiter. May be tender to palpation or asymptomatic * *Extremities:* Fine tremors on both hands, sweaty palms, pretibial myxedema * *Eyes:* Lid lag; exophthalmos in one or both eyes * *Cardiac:* Tachycardia, atrial fibrillation, congestive heart failure, cardiomyopathy * *Integumentary:* Fine hair, warm skin * *Neurologic:* Brisk deep tendon reflexes

Question 35

Graves Disease Labs Look for very low \_\_\_( * If Graves’ disease, will have positive **(1) antibodies**, which is also known as the **(1) immunoglobulins** * The **(1) antibody** is positive with Graves’ disease as well as Hashimoto’s disease.

Answer 35

Look for very low TSH (\<0.05 mU/L) with elevated serum-free T4 and T3. * If Graves’ disease, will have positive **thyrotropin receptor antibodies (TRAb)**, which is also known as the **thyroid-stimulating immunoglobulins (TSIs)** * The **thyroid peroxidase antibody (TPO)** is positive with Graves’ disease as well as Hashimoto’s disease.

Question 36

Graves Disease Workup 1. Check (1). 2. If low, order thyroid \_\_\_\_\_. Look for very ___ TSH (\<0.05 mU/L) with ______ serum-free T4 and elevated T3. (In some patients with very low TSH, only either the serum T4 or the serum T3 will be elevated.) 3. Next step is to order ______ tests to confirm whether Graves’ disease is present ( (1) and (1) or (1)). If thyroid has a single palpable mass/nodule, order thyroid \_\_\_\_\_\_. Refer to \_\_\_\_\_\_\_\_for management.

Answer 36

1. Check TSH. 2. If low, order thyroid panel. Look for very low TSH (\<0.05 mU/L) with elevated serum-free T4 and elevated T3. (In some patients with very low TSH, only either the serum T4 or the serum T3 will be elevated.) 3. Next step is to order antibody tests to confirm whether Graves’ disease is present (TRAb and TPO or TSI). * If thyroid has a single palpable mass/nodule, order thyroid ultrasound. Refer to endocrinologist for management.

Question 37

Graves Disease Imaging Studies * Thyroid \_\_\_\_\_\_ * (1) (RAIU) shows diffuse uptake (goiter). * If solitary toxic nodule, shows warm or “\_\_” nodule or “\_\_\_\_” nodule. Absolute contraindications for this test are pr\_\_\_\_\_ and breast\_\_\_\_\_\_\_.

Answer 37

* Thyroid ultrasound * 24-hour radioactive iodine uptake (RAIU) shows diffuse uptake (goiter). * If solitary toxic nodule, shows warm or “hot” nodule or “cold” nodule. Absolute contraindications for this test are pregnancy and breastfeeding.

Question 38

Graves Treatment * Rx (1)**:* Shrinks thyroid gland/decreases hormone production. * Rx (1)**:* Shrinks thyroid gland/decreases hormone production. Which one is the preferred treatment for moderate to severe hyperthyroidism? (can cause _____ failure).

Answer 38

* Methimazole (Tapazole):* Shrinks thyroid gland/decreases hormone production. * Propylthiouracil (PTU)**:* Shrinks thyroid gland/decreases hormone production. PTU is preferred treatment for moderate to severe hyperthyroidism (can cause liver failure).

Question 39

Side Effects of Methimazole and Propylthiouracil (PTU) What 2 labs are important to monitor? Skin \_\_\_\_ granulocyto\_\_\_\_/aplastic \_\_\_\_, \_\_\_\_\_\_cytopenia - check (1) \_\_\_\_\_\_ necrosis - check (1)

Answer 39

Skin rash, granulocytopenia/aplastic anemia, thrombocytopenia (check complete blood count [CBC] with platelets), hepatic necrosis (monitor CBC, liver function tests [LFTs]).

Question 40

If a pregnant woman has hyperthyroidism? What is the preferred medication? Can you take care of this patient by yourself?

Answer 40

For hyperthyroidism, PTU is preferred treatment, if needed. For high-risk pregnancy, refer to obstetrician.

Question 41

Graves Disease Adjunctive Treatment Rx (1)-(3) Given to alleviate the symptoms of hyperstimulation (i.e., anxiety, tachycardia, palpitations

Answer 41

Betablockers are effective (e.g., propranolol, metoprolol, atenolol).

Question 42

When using Radioactive Iodine to treat Graves - what conditions is it contraindicated to give radioactive iodine? What does radioactive iodine do to the thyroid gland? What will the person need for life?

Answer 42

Contraindicated during pregnancy or lactation. Permanent destruction of thyroid gland results in hypothyroidism for life (needs thyroid supplementation for life).

Question 43

(1) Complication of Graves Disease where an individual’s heart rate, blood pressure, and body temperature can soar to dangerously high levels. Acute worsening of symptoms due to stress or infection. Look for decreased level of consciousness (LOC), fever, abdominal pain. Lifethreatening. Immediate hospitalization needed.

Answer 43

Thyroid Storm (Thyrotoxicosis)

Question 44

Primary Hypothyroidism (1) Most common disease in the US The classic lab finding for hypothyroidism is a ____ TSH with \_\_\_\_free T4 levels (do not confuse with total T4). Diagnosis is based on the lab findings. Some of the most common causes are ______ thyroiditis, post\_\_\_\_\_ thyroiditis, and thyroid ablation with (1) (to treat hyperthyroidism).

Answer 44

Hashimoto's Thyroiditis The classic lab finding for hypothyroidism is a high TSH with low free T4 levels (do not confuse with total T4). Diagnosis is based on the lab findings. Some of the most common causes are Hashimoto’s thyroiditis, postpartum thyroiditis, and thyroid ablation with radioactive iodine (to treat hyperthyroidism).

Question 45

Hashimoto’s Thyroiditis A chronic ______ disorder of the thyroid gland. There is generally no ____ with this thyroid swelling. The body produces destructive antibodies (1) against the thyroid gland that gradually destroys them. Almost all patients (90%) with Hashimoto’s thyroiditis have elevated TPOs. Most patients have developed a goiter. More common in (1) gender with ratio of 8:1.

Answer 45

A chronic autoimmune disorder of the thyroid gland. There is generally no pain with this thyroid swelling. The body produces destructive antibodies (TPOs) against the thyroid gland that gradually destroys them. Almost all patients (90%) with Hashimoto’s thyroiditis have elevated TPOs. Most patients have developed a goiter. More common in women with ratio of 8:1.

Question 46

*Classic Case of Hashimoto's Thyroiditis* A middle-aged-to-older woman who is overweight complains of f\_\_\_\_, weight \_\_\_\_, ____ intolerance, cons\_\_\_\_\_\_, and menstrual abnormalities. May have alopecia on the outer one-third of both eyebrows. Serum ch\_\_\_\_\_\_ is elevated. May have a history of another \_\_\_\_\_\_disorder (e.g., RA, PA).

Answer 46

A middle-aged-to-older woman who is overweight complains of fatigue, weight gain, cold intolerance, constipation, and menstrual abnormalities. May have alopecia on the outer one-third of both eyebrows. Serum cholesterol is elevated. May have a history of another autoimmune disorder (e.g., RA, PA).

Question 47

(1) Severe hypothyroidism is an endocrine emergency that is now rare (mortality rate 30%–40%). Patient presents with cognitive symptoms such as slowed thinking, poor short-term memory, depression (or dementia), hypotension, and hypothermia

Answer 47

Myxedema - Myxedema Coma

Question 48

Hashimoto's Thyroiditis *Labs* 1. Order _____ first (TSH \>\_\_\_ mU/L). 2. If elevated, order TSH again with (1) (free thyroxine). 3. If TSH is ___ and serum-free T4 is \_\_\_, the diagnosis is hypothyroidism. 4. Next step is to order **(1)**: If elevated, confirms Hashimoto’s thyroiditis **(gold-standard test for diagnosing Hashimoto’s thyroiditis)**.

Answer 48

1. Order TSH first (TSH \>5.0 mU/L). 2. If elevated, order TSH again with free T4 (free thyroxine). 3. If TSH is high and serum-free T4 is low, the diagnosis is hypothyroidism. 4. Next step is to order **TPOs**: If elevated, confirms Hashimoto’s thyroiditis **(gold-standard test** for diagnosing Hashimoto’s thyroiditis).

Question 49

(1) Diagnosis If TSH is \>5 mU/L (elevated), but serum-free T4 is within normal range, person is (asymptomatic to mild symptoms of hypothyroidism). Decision to treat with Synthroid should be individualized. Some choose not to treat but recheck same labs again in 12 months.

Answer 49

* Subclinical Hypothyroidism* * (nonpregnant adults)*

Question 50

Hashimoto's Thyroiditis Treatment Rx (1) Dose Range \_\_**-**\_\_ mcg/day Increase Synthroid dose every few weeks until TSH is normalized ( Recheck TSH every __ to __ weeks until TSH is normalized (TSH \<5.0 mU/L). When under control, check TSH every __ months.

Answer 50

Levothyroxine (Synthroid) Dose Range 25**-**50 mcg/day Increase Synthroid dose every few weeks until TSH is normalized (\<5.0 mU/L). Recheck TSH every 6 to 8 weeks until TSH is normalized (TSH \<5.0 mU/L). When under control, check TSH every 12 months.

Question 51

Levothyroxine Side Effects ## Footnote Advise patient to report if pal\_\_\_\_\_, n\_\_\_\_\_ness, or tr\_\_\_\_\_\_ because this means that Synthroid dose is too high (decrease dose until symptoms are gone and TSH is in normal range). Start with _____ dose for older adults or patients with history of heart disease (watch for ang\_\_\_\_\_\_, acute \_\_\_\_, atrial \_\_\_\_\_\_\_)

Answer 51

Advise patient to report if palpitations, nervousness, or tremors because this means that Synthroid dose is too high (decrease dose until symptoms are gone and TSH is in normal range). Start with lowest dose for older adults or patients with history of heart disease (watch for angina, acute myocardial infarction [MI], atrial fibrillation).

Question 52

Exam Tips * Learn to diagnose **(1)** (TSH elevated with normal free T4). * If patient has elevated TSH (\>5.0 mU/L), workup needed for ________ (e.g., order \_\_\_, free \_\_\_). * Start older patients at low dose of Synthroid (\_\_\_–\_\_\_ mcg/day) and gradually increase to avoid adverse ______ effects from overstimulation (palpitations, angina, MI). * Patient with normal free T4 but with elevated TSH—do ___ treat (subclinical hypothyroidism). Recheck TSH in about __ months.

Answer 52

* Learn to diagnose subclinical hypothyroidism (TSH elevated with normal free T4). * If patient has elevated TSH (\>5.0 mU/L), workup needed for hypothyroidism (e.g., order TSH, free T4). * Start older patients at low dose of Synthroid (12.5–25 mcg/day) and gradually increase to avoid adverse cardiac effects from overstimulation (palpitations, angina, MI). * Patient with normal free T4 but with elevated TSH—do not treat (subclinical hypothyroidism). Recheck TSH in about 6 months.

Question 53

Exam Tips * Check TSH every __ to __ weeks (do not order earlier than 6 weeks) to monitor treatment response. If TSH is ___ to ____ mU/L, it is within normal limits and the patient is at the right dose (Synthroid). * (1) treatment results in hypothyroidism for life. Supplement with thyroid hormone for life. * If TSH is suppressed (TSH \<0.05 mU/L), workup needed for \_\_\_\_\_\_\_. * Chronic amenorrhea and hypermetabolism result in \_\_\_\_\_\_. Supplement with (1) and (1) 1,200 mg; engage in weight-bearing exercises.

Answer 53

* Check TSH every 6 to 8 weeks (do not order earlier than 6 weeks) to monitor treatment response. If TSH is 0.05 to 5.0 mU/L, it is within normal limits and the patient is at the right dose (Synthroid). * Radioactive iodine treatment results in hypothyroidism for life. Supplement with thyroid hormone for life. * If TSH is suppressed (TSH \<0.05 mU/L), workup needed for hyperthyroidism. * Chronic amenorrhea and hypermetabolism result in osteoporosis. Supplement with calcium and with vitamin D 1,200 mg; engage in weight-bearing exercises.

Question 54

Clinical Pearls * Many patients with subclinical hypothyroidism will eventually develop? * Advise patient to _____ Synthroid tablets with teeth before swallowing with \_\_\_\_for better absorption. These tablets are synthetic T4 (levothyroxine). * Alternative medicine practitioners are more likely to prescribe _____ thyroid tablets (desiccated thyroid glands from pigs), which contain _____ T3 and T4 for hypothyroidism. * All \_\_\_\_\_thyroid patients should be referred to an endocrinologist as soon as possible.

Answer 54

* Many patients with subclinical hypothyroidism will eventually develop overt hypothyroidism. * Advise patient to crush Synthroid tablets with teeth before swallowing with water for better absorption. These tablets are synthetic T4 (levothyroxine). * Alternative medicine practitioners are more likely to prescribe Armour thyroid tablets (desiccated thyroid glands from pigs), which contain natural T3 and T4 for hypothyroidism. * All hyperthyroid patients should be referred to an endocrinologist as soon as possible.

Question 55

(1) A chronic metabolic disorder affecting the body’s metabolism of carbohydrates and fat. The result is microvascular and macrovascular damage, neuropathy, and immune system effects.

Answer 55

Diabetes Mellitus

Question 56

*(1) Damage* Retinopathy, nephropathy, and neuropathy *(1) Damage* Atherosclerosis, heart disease (coronary artery disease, MI)

Answer 56

Microvascular Damage Retinopathy, nephropathy, and neuropathy Macrovascular Damage Atherosclerosis, heart disease (coronary artery disease, MI)

Question 57

* Target organs in Diabetes Mellitus* * (4)* DM is the most common reason for (2) in the United States

Answer 57

Eyes, kidneys, heart/vascular system, peripheral nerves (especially in the feet) DM is the most common reason for chronic renal failure requiring dialysis and lower limb amputations in the United States.

Question 58

Type 1 Diabetes Mellitus = * If uncorrected, body ___ will be used for fuel. * \_\_\_\_\_\_, the metabolic product of fat breakdown, build up in the body until the result is diabetic ketonic acidosis (ketoacidosis) and coma. * Most patients are juv\_\_\_\_\_; occasionally occurs in adults (maturity onset diabetes of the young [MODY]). The Centers for Disease Control and Prevention (CDC) reports 5% to 10% of U.S. cases.

Answer 58

The massive destruction of B-cells in the islets of Langerhans results in an abrupt cessation of insulin production. * If uncorrected, body fat will be used for fuel. * Ketones, the metabolic product of fat breakdown, build up in the body until the result is diabetic ketonic acidosis (ketoacidosis) and coma. * Most patients are juveniles; occasionally occurs in adults (maturity onset diabetes of the young [MODY]). The Centers for Disease Control and Prevention (CDC) reports 5% to 10% of U.S. cases.

Question 59

Type 2 Diabetes Mellitus = * Has strong g\_\_\_\_component. * Type 2 DM represents \_\_% to \_\_% of U.S. cases. * ______ epidemic is increasing rates of type 2 DM in younger patients.

Answer 59

Progressive decreased secretion of insulin (with peripheral insulin resistance) resulting in a chronic state of hyperglycemia and hyperinsulinemia. * Has strong genetic component. * Type 2 DM represents 90% to 95% of U.S. cases. * Obesity epidemic is increasing rates of type 2 DM in younger patients.

Question 60

*Risk Factors for Type 2 Diabetes Mellitus (Screen These Patients)* * (1) (body mass index [BMI] 25 or greater) * _______ obesity; sedentary lifestyle * _______ syndrome * Ethnicities? * History of ______ diabetes or infant weighing \>\_\_ lb at birth * Impaired (1) (IFG) or (1) (IGT) is considered at higher risk for type 2 DM (prediabetes)

Answer 60

* Overweight or obese (body mass index [BMI] 25 or greater) * Abdominal obesity; sedentary lifestyle * Metabolic syndrome * Hispanic, African American, Asian, Pacific Islander, or American Indian ancestry or positive family history * History of gestational diabetes or infant weighing \>9 lb at birth * Impaired fasting blood sugar/glucose (IFG) or impaired glucose tolerance (IGT) is considered at higher risk for type 2 DM (prediabetes)

Question 61

* Serum Blood Glucose Norms: Nondiabetic Adults* * FPG:* __ to 100 mg/dL * Peak postprandial plasma glucose:* * Glycosylated hemoglobin (A1C* * Definition of A1C =*

Answer 61

* FPG:* **70 to 100 mg/dL** * Peak postprandial plasma glucose:* **\<180 mg/dL** * Glycosylated hemoglobin (**A1C \<6.0%**):* * A1C =* the average blood glucose levels over previous **3 month**s; no fasting required; test measures excess glucose that attaches to the hemoglobin of the red blood cells

Question 62

*Metabolic Syndrome* Other names are insulin-resistance syndrome and syndrome X Affected people have higher risk of type 2 DM and cardiovascular disease Presence of any ____ of the following four traits: * Obesity, abdominal obesity. Waist size: * *Male*: \>\_\_ inches (102 cm) * *Female*: \>\_\_ inches (88 cm) * *Hypertension*: BP \>\_\_\_/\_\_\_ mmHg * *Dyslipidemia*: Triglycerides \>\_\_\_ mg/dL, high-density lipoprotein (HDL) * *Hyperglycemia*: Fasting plasma glucose (FPG) \>\_\_\_\_ mg/dL or type 2 DM

Answer 62

Presence of any three of the following four traits: * Obesity, abdominal obesity. Waist size: * *Male*: \>40 inches (102 cm) * *Female*: \>35 inches (88 cm) * *Hypertension*: BP \>130/85 mmHg * *Dyslipidemia*: Triglycerides \>150 mg/dL, high-density lipoprotein (HDL) \<40 in males or \<50 in females * *Hyperglycemia*: Fasting plasma glucose (FPG) \>100 mg/dL or type 2 DM

Question 63

*Increased Risk of Diabetes Mellitus (Prediabetes)* Glycosylated hemoglobin (A1C) between \_\_\_\_% and \_\_\_\_% *or* Fasting glucose of \_\_\_\_to ____ mg/dL (impaired FPG) *or* Two-hour oral glucose tolerance test (OGTT; 75 g load) of \_\_\_\_to \_\_\_\_mg/dL

Answer 63

Glycosylated hemoglobin (A1C) between 5.7% and 6.4% *or* Fasting glucose of 100 to 125 mg/dL (impaired FPG) *or* Two-hour oral glucose tolerance test (OGTT; 75 g load) of 140 to 199 mg/dL

Question 64

*Diagnostic Criteria for Diabetes Mellitus* A1C ≥\_\_\_% *or* FPG ≥\_\_\_\_\_mg/dL (fasting is no caloric intake for at least 8 hours) *or* Symptoms of hyperglycemia (3) plus random blood glucose ≥\_\_\_\_mg/dL *or* Two-hour plasma glucose ≥\_\_\_\_mg/dL during an OGTT with a 75-g glucose load

Answer 64

A1C ≥6.5% *or* FPG ≥126 mg/dL (fasting is no caloric intake for at least 8 hours) *or* Symptoms of hyperglycemia (polyuria, polydipsia, polyphagia) plus random blood glucose ≥200 mg/dL *or* Two-hour plasma glucose ≥200 mg/dL during an OGTT with a 75-g glucose load

Question 65

* Diabetes Labs* * Newly diagnosed diabetics:* Check A1C every __ months until blood glucose controlled or when changing therapy, then check ___ a year * **\_\_\_\_\_ profile** at least once a year with 9- to 12-hour fasting * Random or “on-spot” urine for **\_\_\_\_\_\_\_** at least once a year * Urine (1) better than microalbumin test (spot urine sample) for evaluating microalbumin (the earliest sign of diabetic renal disease) * If positive, order (1) for protein and creatinine

Answer 65

*Newly diagnosed diabetics:* Check A1C every 3 months until blood glucose controlled or when changing therapy, then check twice a year (every 6 months) * Lipid profile at least once a year with 9- to 12-hour fasting * Random or “on-spot” urine for microalbuminuria at least once a year * Urine albumin-to-creatinine ratio better than microalbumin test (spot urine sample) for evaluating microalbumin (the earliest sign of diabetic renal disease) * If positive, order 24-hour urine for protein and creatinine

Question 66

*Diabetes Labs* **Rx (3)** with tighter control of blood glucose/A1C decreases progression and **lowers mortality from kidney disease** Check electrolytes (3)), l\_\_\_\_\_ function panel, and (1) hormone

Answer 66

**ACEI/ARBS/ARNIS** with tighter control of blood glucose/A1C decreases progression and lowers mortality from kidney disease Check electrolytes (potassium, magnesium, sodium), liver function panel, and TSH

Question 67

Diabetes Treatment Plan ## Footnote * Every visit:* Check B\_\_, f\_\_\_, w\_\_\_\_ and BMI, blood \_\_\_\_. * Vibration sense (128-Hz tuning fork):* Place on bony prominence of the __ toe at the ____ joint; if unable to sense vibration or asymmetry, patient has (1) * Light and deep touch, numbness:* Place at right angle on plantar surface, push into skin until it buckles slightly (\_\_\_\_\_\_\_ tool) Check pedal \_\_\_\_, ankle reflexes, and skin for acanthosis \_\_\_\_\_\_\_, insulin injection or insertion sites, l\_\_\_dystrophy

Answer 67

* Every visit:* Check BP, feet, weight and BMI, blood sugar. * Vibration sense (128-Hz tuning fork):* Place on bony prominence of the big toe (metatarsophalangeal [MTP] joint); if unable to sense vibration or asymmetry, patient has peripheral neuropathy * Light and deep touch, numbness:* Place at right angle on plantar surface, push into skin until it buckles slightly (monofilament tool) Check pedal pulses, ankle reflexes, and skin for acanthosis nigricans, insulin injection or insertion sites, lipodystrophy

Question 68

*Preventive Care Recommendations* The CDC recommends adults \>\_\_\_ years be given **\_\_\_\_\_\_ vaccine** in two doses, 2 to 6 months apart. **\_\_\_\_\_\_\_ immunization** every year. *\_\_\_\_\_\_\_\_\_\_\_\_ polysaccharide vaccine:* If vaccinated before 65 years of age, give one-time revaccination in __ years; if age 65 years, give one dose of the vaccine only. Prescribe ____ \_\_mg if high risk for MI, stroke (if \<30 years, not recommended). * (1):* Yearly ______ eye exam needed. If type 2, eye exam at diagnosis; if type 1 DM, first eye exam needed 5 years after diagnosis. * (1):* Refer to ____ or twice a year, especially with older diabetics. * BP:* Goal is \_\_\_/\_\_\_ mmHg. * (1) care:* Important (poor oral health associated with heart disease).

Answer 68

The CDC recommends adults \>50 years be given Shingrix in two doses, 2 to 6 months apart. Influenza immunization every year. *Pneumococcal polysaccharide vaccine:* If vaccinated before 65 years of age, give one-time revaccination in 5 years; if age 65 years, give one dose of the vaccine only. Prescribe aspirin 81 mg if high risk for MI, stroke (if \<30 years, not recommended). * Ophthalmologist:* Yearly dilated eye exam needed. If type 2, eye exam at diagnosis; if type 1 DM, first eye exam needed 5 years after diagnosis. * Podiatrist:* Refer to once or twice a year, especially with older diabetics. * BP:* Goal is 130/80 mmHg. * Dental/tooth care:* Important (poor oral health associated with heart disease).

Question 69

*Dietary and Nutrition Recommendations (or Macronutrients)* ## Footnote *Alcohol:* Advise females not to exceed ___ drink per day and males ___ drinks per day. Monitor carbohydrate intake (i.e., carbohydrate \_\_\_\_\_\_). \_\_\_\_\_\_ fat (animal fats, beef fat) intake should be \<7% of total calories. Reduce intake of ____ fats (will lower low-density lipoprotein [LDL] and increase HDL), such as most fr\_\_\_\_ foods and “j\_\_\_\_foods.” Refer patient to a _____ at least once or more often if problems with diet. Routine vitamin supplementation of antioxidants?

Answer 69

*Alcohol:* Advise females not to exceed one drink per day and males two drinks per day. Monitor carbohydrate intake (i.e., carbohydrate counting). Saturated fat (animal fats, beef fat) intake should be \<7% of total calories. Reduce intake of trans fats (will lower low-density lipoprotein [LDL] and increase HDL), such as most fried foods and “junk foods.” Refer patient to a dietitian at least once or more often if problems with diet. Routine vitamin supplementation of antioxidants is not yet advised.

Question 70

Hypoglycemia *_High risk:_* * *Level 1 hypoglycemia* (glucose alert): FBS ≤\_\_\_ mg/dL * *Level 2 hypoglycemia*: Blood glucose ≤\_\_\_mg/dL Look for what symptoms? What medication can mask hypoglycemia symptoms?

Answer 70

*_High risk:_* * *Level 1 hypoglycemia* (glucose alert): FBS ≤70 mg/dL * *Level 2 hypoglycemia*: Blood glucose ≤54 mg/dL Look for: Sweaty palms, tiredness, dizziness, rapid pulse, strange behavior, confusion, and weakness; If patient on beta-blockers, the hypoglycemic response can be blunted or blocked.

Question 71

Hypoglycemia Treatment (1)= preferred for conscious patients * Other options are 4 oz of \_\_\_\_juice, regular\_\_\_\_ drink, hard c\_\_\_\_\_. * Think of the “\_\_-\_\_ Rule”: 15 g of ______ to raise blood sugar, _____ in __ minutes. * When blood glucose is normalized, do what afterward? (1) = for patients at significant risk for severe hypoglycemia (BG \<54 mg/dL)

Answer 71

Glucose (15 g) preferred for conscious patients * Other options are 4 oz of , orange juice, regular soft drink, hard candy. * Think of the “15-15 Rule”: 15 g of carbohydrates to raise blood sugar, recheck in 15 minutes. * When blood glucose is normalized, eat a meal or snack afterward (complex carbohydrates, protein). Glucagon*:* Prescribe for patients at significant risk for severe hypoglycemia. Severe hypoglycemia is defined as blood glucose \<54 mg/dL.

Question 72

Illness and Surgery ## Footnote Should you stop taking antidiabetic medication during illness? Requires ______ self-monitoring of blood glucose. Eat _____ amounts of food every __ to *\_*\_ hours to keep FBG as normal as possible. *Contact healthcare provider if:* Dehy\_\_\_\_, v\_\_\_\_\_, or di\_\_\_\_ for several hours; blood glucose is \>\_\_\_\_mg/dL; changes in L _ \_ (feel sleepier than normal/cannot think clearly; urine with 1+ or higher \_\_\_\_\_\_\_).

Answer 72

Do not stop taking antidiabetic medicine. Keep taking insulin or oral medications as scheduled unless fasting blood glucose (FBG) is lower than normal. Requires frequent self-monitoring of blood glucose. Eat small amounts of food every 3 to 4 hours to keep FBG as normal as possible. *Contact healthcare provider if:* Dehydrated, vomiting, or diarrhea for several hours; blood glucose is \>300 mg/dL; changes in LOC (feel sleepier than normal/cannot think clearly; urine with 1+ or higher ketones).

Question 73

Hypoglycemia and Exercise What happens to blood sugar when you exercise? What should you do to your medicine dosage? or do what afterwards to compensate? * If patient does not compensate (\_\_\_\_\_ the dose of insulin, _____ caloric intake, sn\_\_\_\_\_ before and after), there is an increased risk of hypoglycemia within a few hours. * *Example:* If patient exercises in the afternoon, high risk of hypoglycemia at \_\_\_\_/bedtime if they do not compensate by eating snacks, eating more food at dinner, or lowering insulin dose.

Answer 73

Increases glucose utilization by the muscles. Patients may need to reduce their usual dose of medicine (or eat snacks before the activity and afterward to compensate). * If patient does not compensate (reducing the dose of insulin, increasing caloric intake, snacking before and after), there is an increased risk of hypoglycemia within a few hours. * *Example:* If patient exercises in the afternoon, high risk of hypoglycemia at night/bedtime if they do not compensate by eating snacks, eating more food at dinner, or lowering insulin dose.

Question 74

Snacks for Exercise * Eat _____ carbohydrates (2) **before** or during exercise. * Eat \_\_\_\_\_\_carbohydrates ((1) bars) **after** exercise (avoids postexercise hypoglycemia).

Answer 74

* Eat simple carbohydrates (candy, juices) before or during exercise. * Eat complex carbohydrates (granola bars) after exercise (avoids postexercise hypoglycemia).

Question 75

Dawn Phenomenon =

Answer 75

Daily surge of fasting blood glucose levels between 4-8am Normal physiologic event due to a hormonal surge, without normal insulin responses, diabetics experience rising FBG levels - healthy people can produce the insulin to combat this phenomenon

Question 76

Somogyi Effect =

Answer 76

***(Rebound Hyperglycemia)*** Severe **nocturnal hypoglycemia stimulates** counterregulatory hormones, such as **glucago**n, to be released from the liver. The high levels of glucagon in the systemic circulation result in **high FBG by 7 a.m.** The condition is due to overtreatment with the evening and/or bedtime insulin (dose is too high). More common in people with type 1 DM.

Question 77

Somogyi vs. Dawn Effect * If the blood sugar level is low at 2 a.m. to 3 a.m., suspect the ______ effect.* * If the blood sugar level is normal or high at 2 a.m. to 3 a.m., it's likely the _____ phenomenon.*

Answer 77

* If the blood sugar level is low at 2 a.m. to 3 a.m., suspect the Somogyi effect.* * If the blood sugar level is normal or high at 2 a.m. to 3 a.m., it's likely the dawn phenomenon.*

Question 78

Somogyi Effect * Diagnosis* * Treatment*

Answer 78

* Diagnosis:* Check blood glucose very early in the morning (3 a.m.) for 1 to 2 weeks. * Treatment:* Eat a snack before bedtime or eliminate dinnertime intermediate-acting insulin (NPH) dose or lower the bedtime dose for both NPH and regular insulin.

Question 79

Diabetic Retinopathy * (1) = new growth of fragile arterioles in retina) * (1) = dot and blot hemorrhages due to neovascularization * (1) spots or soft exudates (nerve fiber layer infarcts), and hard exudates.

Answer 79

* Neovascularization = new growth of fragile arterioles in retina * Microaneurysms dot and blot hemorrhages due to neovascularization * Cotton-wool spots or soft exudates (nerve fiber layer infarcts), and hard exudates.

Question 80

Diabetic Retinopathy Screening When to screen * Patients with type 1 DM:* * Patients with type 2 DM:*

Answer 80

* Patients with type 1 DM:* Screen after age 10 years. * Patients with type 2 DM:* Refer to ophthalmologist shortly after diagnosis; then eye exam needed every 6 to 12 months.

Question 81

Diabetic Foot Care Patients with peripheral neuropathy should avoid excessive running or walking to minimize the risk of foot injury. * **Patients with type 2 DM screening?** * Wear shoes that \_\_\_properly. Never go \_\_\_\_\_\_. * Check feet \_\_\_\_, especially the soles of the feet (use \_\_\_\_\_). * Trim nails _____ (not rounded) to prevent ingrown toenails. * Report \_\_\_ness, skin breakdown, or trauma to healthcare provider immediately (main cause of lower leg _______ in the United States).

Answer 81

Patients with peripheral neuropathy should avoid excessive running or walking to minimize the risk of foot injury. * **Patients with type 2 DM: Refer to podiatrist at least once a year.** * Wear shoes that fit properly. Never go barefoot. * Check feet daily, especially the soles of the feet (use mirror). * Trim nails squarely (not rounded) to prevent ingrown toenails. * Report redness, skin breakdown, or trauma to healthcare provider immediately (main cause of lower leg amputations in the United States).

Question 82

Deformity of the foot that is caused by joint and bone dislocation and fractures due to neuropathy and loss of sensation to the foot and ankle. May affect only one foot or both feet. If severe, foot deformity includes collapse of midfoot arch **(rocker-bottom foot;**

Answer 82

***Charcot’s Foot and Ankle (Neuropathic Arthropathy)***

Question 83

Biguanides (1) MOA

Answer 83

Metformin (Glucophage) Decreases gluconeogenesis and decreases peripheral insulin resistance

Question 84

Metformin Incidence of hypoglycemia? Effect on weight loss? Side effects?

Answer 84

Rarely causes hypoglycemia Neutral for weight change and has potential for modest weight loss - preferred for obese patients Side effects: diarrhea, nausea, vitamin B12 deficiency (supplement)

Question 85

Metformin Contraindications * R\_\_\_\_\_ disease * H\_\_\_\_\_\_ disease ac\_\_\_\_\_ * Al\_\_\_\_\_\_, hy\_\_\_\_\_ What labs should you monitor? (2)

Answer 85

* Renal disease * Hepatic disease acidosis * Alcoholics, hypoxia Monitor renal function (Cr, GFR, UA) and LFTS

Question 86

Metformin Adverse Effects Increased risk for **(1)** during hypoxia, hypoperfusion, renal insufficiency Usually inpatient - metformin should be held on day of this procedure **(1)** and for 48 hours after? What should you check beforehand?

Answer 86

**Increased risk for lactic acidosis (pH \<7.25)** during hypoxia, hypoperfusion, renal insufficiency **IV contrast dye testing -** hold metformin on day of procedure and 48 hours after - check baseline creatinine and recheck after procedure - if SrCr remains elevated after procedure, do not restart metformin, Cr must be normalized before drug resumed

Question 87

Sulfonylureas Why are they not commonly used anymore? (2)

Answer 87

High risk of severe hypoglycemia Increased risk of cardiovascular mortality (based on studies of older sulfonylurea tolbutamide)

Question 88

Sulfonylureas MOA * First generation (1)* * Second generation (3)* Half life =

Answer 88

Stimulates Beta cells of pancreas to secrete more insulin *_First generation_* * Chlorpropamide (Diabinese) *_Second generation_* * Glipizide (Glucotrol, Glucotrol XL) * Glyburide (Diabeta) * Glimepiride (Amaryl) Long half life = 12 hours

Question 89

Sulfonylureas Incidence of hypoglycemia? Cardiovascular risk? Effect on weight? * Increased risk of \_\_\_\_\_sensitivity (use sunscreen) * Blood ______ (monitor \_\_\_) * Avoid if impaired (2) function (monitor (3))

Answer 89

High risk of severe hypoglycemia Increased risk of cardiovascular mortality Weight gain (monitor weight and BMI) * Increased risk of photosensitivity (use sunscreen) * Blood dyscrasia (monitor CBC * Avoid if impaired hepatic and renal function (monitor LFTs, creatinine, UA)

Question 90

Thiazolidinediones (1) MOA

Answer 90

Pioglitazone (Actos) Enhances insulin sensitivity in muscle tissue (decreases peripheral tissue resistance) and reduces hepatic glucagon production (gluconeogenesis).

Question 91

Thiazolidinediones When should you take it? Can it be combined with other anti-diabetics?

Answer 91

Take daily with breakfast Can be combined with metformin, sulfonylureas, glucagonlike peptide 1 (GLP-1), sodium-glucose cotransporter-2 (SGLT2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, insulins.

Question 92

Thiazolidinediones Contraindications (Pioglitazone) * Black Box Warning = * Causes (2) that can aggravate or precipitate CHG * Effect on weight = * Avoid if history of (1) - rare * Active ____ disease, Type 1 DM, pregnancy * Labs to check (1)

Answer 92

* Black Box Warning = DO NOT USE with class III/IV heart disease, symptomatic HF (CHF) * Causes water retention and edema that can aggravate or precipitate CHG * Causes weight gain * Avoid if history of Bladder Cancer- rare * Active liver disease, Type 1 DM, pregnancy * *Labs:* Check LFTs

Question 93

Bile Acid Sequestrants MOA (3)

Answer 93

Reduces hepatic glucose production and may reduce intestinal absorption of glucose Cholestyramine (Questran) Colesevelam (Welchol) Colestipol (Colestid)

Question 94

Bile Acid Sequestrants SE How to take, what can it lower? SE mostly ___ related = SE are a common reason for? So what should you do? Can effect (2), so check what labs?

Answer 94

Take with meals, lowers LDL SE mostly GI related = Nausea, bloating, constipation, increased triglycerides SE are a common reason for noncompliance, start patients on low dose and titrate up slowly Kidney and liver effects (check Cr, GFR, LFTs)

Question 95

Meglitinide (Glinides) (2) MOA

Answer 95

Repaglinide (Prandin) Nateglinide (Starlix) Stimulates pancreatic secretion of insulin

Question 96

Meglitinides Indicated for type 2 diabetics with (1) Effect on weight = Incidence of hypoglycemia? * Half life = * How to take? * If skipping a meal? * SE =

Answer 96

Indicated for type 2 diabetics with postprandial hyperglycemia Weight neutral May cause hypoglycemia * Rapid acting with very short half life (\<1 hour) * Take before meals or up to 30 minutes after a meal * Hold dose if skipping a meal * SE = bloating, abdominal cramps, diarrhea, flatulence

Question 97

Rapid Acting Insulin (3) * Onset = * Peak = * Duration =

Answer 97

**Insulin Aspart (Novolog)** **Insulin Lispro (Humalog)** **Insulin Glulisine (Apidra)** * Onset = 15 minutes * Peak = 30 min - 2.5 hr * Duration = 4.5 hr

Question 98

Short Acting Insulin (1) * Onset = * Peak = * Duration =

Answer 98

**Humulin R (Regular)** * Onset = 30 min * Peak = 1-5 hour * Duration = 6-8 hours

Question 99

Intermediate Acting Insulin (1) * Onset = * Peak = * Duration =

Answer 99

**Insulin NPH** * Onset = 1 hour * Peak = 6-14 hr * Duration = 18-24 hr

Question 100

Long Acting (basal) Insulin (2) * Onset = * Peak = * Duration =

Answer 100

**Insulin Glargine (Lantus)** **Insulin Detemir (Levemir)** * Onset = 1 hour * Peak = no peak * Duration = 24 hour

Question 101

Premixed Insulin Humulin 70/30 = (\_\_\_\_/\_\_\_\_\_) Humulin 50/50 Other types available * Onset = * Peak = * Duration =

Answer 101

Humulin 70/30 = (NPH/Regular) Humulin 50/50 Other types available * Onset = 30 min * Peak = 4.4 hr * Duration = 24 hours

Question 102

Basal Insulin * Peaks in (1) and then _____ level for most of the day * Humulin \_\_ * ____ (insulin glargine), _____ (insulin detemir) * Give ___ a day at the ____ time

Answer 102

* Peaks in 1 hour and then steady level for most of the day * Humulin N * Lantus (insulin glargine), Levemir (insulin detemir) * Give once a day at the same time

Question 103

Insulin Mixtures ## Footnote Humulin 70/30 (70% NPH \_\_\_\_, 30% \_\_\_\_insulin) If mixing NPH and regular insulin, use the mixture immediately Rapid-acting insulin can be mixed with NPH, but it should be used ___ minutes before a meal

Answer 103

Humulin 70/30 (70% NPH insulin, 30% regular insulin) If mixing NPH and regular insulin, use the mixture immediately Rapid-acting insulin can be mixed with NPH, but it should be used 15 minutes before a meal

Question 104

Insulin Pumps Insulin pumps require in\_\_\_\_\_ training; they are expensive. Can be used for ___ type 1 and type 2 diabetics. Patients should remove pump when sw\_\_\_\_\_ or sh\_\_\_\_\_\_.

Answer 104

Insulin pumps require intensive training; they are expensive. Can be used for both type 1 and type 2 diabetics. Patients should remove pump when swimming or showering.

Question 105

Clinical Pearls ## Footnote \_\_\_\_-acting insulins (insulin lispro) are used mostly by type __ diabetics before each \_\_\_. Intermediate-acting insulin (NPH) can be used ___ or ____ a day.

Answer 105

Rapid-acting insulins (insulin lispro) are used mostly by type 1 diabetics before each meal. Intermediate-acting insulin (NPH) can be used once or twice a day.

Question 106

Alpha-Glucosidase Inhibitor (2) MOA Incidence of hypoglycemia? Effect on A1C? SE =

Answer 106

Acarbose (Precose), Miglitol (Glyset) Slows intestinal carbohydrate digestion and absorption, a nonsystemic oral drug Does not cause hypoglycemia Modest effect on A1C GI SE = flatulence, diarrhea

Question 107

Glucagon-Like-Peptide Receptor Agonists (GLP-1 RAs) (4)

Answer 107

**Exenatide (Byetta)** **Liraglutide (Victoza)** **Dulaglutide (Trulicity)** **Semaglutide (Ozempic)**

Question 108

GLP-1 RAs MOA

Answer 108

**Stimulate GLP-1, causing an increase in insulin production and inhibiting postprandial glucagon release (will decrease postprandial hyperglycemia); increase satiety**

Question 109

GLP-1 RA Effects Effect on hypoglycemia? Effect on cardiovascular disease? Effect on weight loss?

Answer 109

Does not cause hypoglycemia Reduces cardiovascular disease (CVD) events/death and death from kidney disease Causes weight loss, suppresses appetite

Question 110

GLP-1 RA Side Effects and Contraindications * Side Effects * **\_\_\_\_\_titis (monitor (2))** * **Medullary (1)** in animals * C-cell \_\_\_\_\_\_\_\_ * Contraindications * **Personal or family history of (1)\*** * MEN-2 =

Answer 110

* Side Effects * **Pancreatitis (monitor amylase, lipase)** * **Medullary thyroid tumors** in animals * C-cell hyperplasia * Contraindications * Personal or family history of **medullary thyroid carcinoma** * MEN-2 = Multiple endocrine neoplasia syndrome type-2

Question 111

Sodium Glucose Cotransporter-2 Inhibitors (SGLT-2 inhibitors) **MOA** **(3)**

Answer 111

**Block glucose reabsorption of glucose by the kidney (proximal nephron) and increase glucosuria** **Canagliflozin (Invokana)** **Dapagliflozin (Farxiga)** **Empagliflozin (Jardiance)**

Question 112

SGLT-2 Inhibitors Effects Effect on hypoglycemia? Effect on Cardiovascular and Kidney disease? Effect on weight?

Answer 112

No hypoglycemia Reduces CVD events/death, Helps slow progression of CKD Causes weight loss/hypotension (volume depletion)

Question 113

SGLT-2 Inhibitor Side and Adverse Effects Renal signs and symptoms\* = FDA warning = Warning =

Answer 113

**Increased risk of urinary tract infections (UTIs) and pyelonephritis (urosepsis),** polyurea, increased creatinine FDA warning = may lead to **DKA (**symptoms of difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness) Increased risk of leg and foot **amputations**

Question 114

Dipeptidyl Peptidase-4 Inhibitors (DPP-4 Inhibitors) **MOA** **(3)**

Answer 114

**Blocks action of DPP-4, an enzyme that destroys the hormone incretin, increase active incretin concentrations → increase insulin secretion and decrease glucagon** Sitagliptin (Januvia) Saxagliptin (Onglyza) Linagliptin (Tradjenta) *Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within minutes after eating. One of their many physiological roles is to* ***regulate the amount of insulin that is secreted after eating, Incretin effect is reduced in type 2 diabetes***

Question 115

DPP-4 Inhibitors Effects Effect on hypoglycemia? Effect on Cardiovascular disease? Effect on Kidneys? Effect on weight?

Answer 115

No Hypoglycemia CARDIOVASCULAR EFFECTS NEUTRAL: As a class, DPP4i are not associated with any increase or reduction of MACE, all-cause mortality, and heart failure. Saxagliptin seems to be associated with an increased risk of hospitalization for heart failure. RENOPROTECTIVE effect by delaying kidney disease progression and decreasing albuminuria WEIGHT NEUTRAL

Question 116

DPP-4 Inhibitors FDA Warning (3)

Answer 116

May cause **joint pain** that can be severe and disabling (may occur on day 1 or years later) **Angioedema/urticaria** **Acute pancreatitis**

Question 117

Can you use GLP-1 RAs (glutides) and DPP-4 Inhibitors (gliptins) at the same time?

Answer 117

Do not combine incretin mimetics (Exenatide (byetta), Liraglutide (Victoza)) with any incretin enhancers ( Sitagliptin (Januvia), Saxagliptin (Onglyza)). Both act on incretin.

Question 118

Amylin Mimetic/Analog **MOA** **(1)**

Answer 118

**Decreases glucagon secretion; slows gastric emptying; leads to feeling satiety early** **Symplin**

Question 119

Amylin Mimetic (Symlin) Administration Route, Dosing frequency Causes hypoglycemia if used with?

Answer 119

*Route:* Injection, frequent dosing that requires patient training Can cause hypoglycemia if used with insulin (decrease insulin dose)

Question 120

Prescribing Tips: Type 2 Diabetics * First step in managing a patient with mild A1C elevation? * In addition to lifestyle, **Rx (1)** is **first-line treatment for most type 2 diabetics**. **Starting dose? Max dose?** * If metformin dose is at maximum (and blood sugar or A1C is still high), add a **Rx (1)** (e.g., Glucotrol XL 20 mg/day). OR * If patient is on a sulfonylurea at the maximum dose (e.g., Glucotrol XL 40 mg/d) and blood sugar/A1C is still elevated, then add **Rx (1)**.

Answer 120

* Try **lifestyle changes (weight loss) for 3 to 6 months** if mild A1C elevation. * In addition to lifestyle**, metformin is first-line treatment for most type 2 diabetics. Start on metformin 500 mg daily (maximum dose is 2,000 mg/dL, or 2 g).** * If metformin dose is at maximum (and blood sugar or A1C is still high), add a sulfonylurea (e.g., Glucotrol XL 20 mg/day). OR * If patient is on a sulfonylurea at the maximum dose (e.g., Glucotrol XL 40 mg/d) and blood sugar/A1C is still elevated, then add metformin.

Question 121

Prescribing Tips: Type 2 Diabetics Choice of second or third agent is any other drug class used to treat type 2 DM. * If on maximal metformin dose (2 g), other choices to add are (1) (Januvia, Onglyza), (1) (Byetta), and/or (1) (TZDs; Actos), others. * Do not combine insulins with meglitinides, why?

Answer 121

* If on maximal metformin dose (2 g), other choices to add are DPP-4 inhibitors (Januvia, Onglyza), incretin mimetics (Byetta), and/or thiazolidinediones (TZDs; Actos), others. * Do not combine insulins with meglitinides (severe hypoglycemia). * Sitagliptin (januvia) = DPP-4i* * Exenatide (byetta) = GLP-RA*

Question 122

Prescribing Tips: Type 2 Diabetics ## Footnote Presence of CVD and/or chronic kidney disease, or heart failure with reduced ejection fraction (HFrEF), start on an **(1) and/or (1)** If blood sugar or A1C is still elevated and patient is on both metformin and sulfonylurea, consider starting patient on a **(1)** If patient refuses insulin, other options are **(1)** (Actos), **(1) (**Byett)a, others. Keep in mind the contraindications for each drug class.

Answer 122

Presence of CVD and/or chronic kidney disease, or heart failure with reduced ejection fraction (HFrEF), start on an **SGLT-2 inhibitor and/or GLP-1 RA.** If blood sugar or A1C is still elevated and patient is on both metformin and sulfonylurea, consider starting patient on a basal insulin (Lantus SC once a day). If patient refuses insulin, other options are **thioglitazones** (Actos**), GLP-1 RA Byetta, others**. Keep in mind the contraindications for each drug class.

Question 123

Diabetes Medications Effect on Weight Medications that cause weight loss Medications that cause weight gain Medications weight neutral

Answer 123

Weight Loss = **Metformin, GLP-1 RAs, DPP-4 SGLT-2i** Weight Gain = **Insulin, Sulfonylureas, TZDs, Meglitinides** Weight Neutral = Meglitinides? Bile Acid-Sequestrants (Welchol), Alpha-glucosidase inhibitors

Question 124

Diabetes Management Tips ## Footnote Refer to (1) to learn about ______ counting. The ADA recommends f\_\_\_and p\_\_\_\_\_counting as well. _______ changes are first-line treatment. (1) and (1) protect the heart and kidneys and promotes weight loss. Eating more f\_\_\_\_ and whole _____ (brown rice, whole wheat) may help. \_\_\_\_\_\_\_ increases cellular glucose uptake in the body. Type 2 diabetics not well controlled on multiple oral agents and diet and lifestyle changes are good candidates for (1) therapy.

Answer 124

Refer to dietitian to learn about carbohydrate counting. The ADA recommends fat and protein counting as well. Lifestyle changes are first-line treatment. SGLT-2 inhibitors and GLP-1 RAs protect the heart and kidneys and promotes weight loss. Eating more fiber and whole grains (brown rice, whole wheat) may help. Exercise increases cellular glucose uptake in the body. Type 2 diabetics not well controlled on multiple oral agents and diet and lifestyle changes are good candidates for basal insulin therapy.

Question 125

Diabetes Complications ## Footnote * Eyes:* C\_\_\_\_\_, diabetic \_\_\_\_\_\_, \_\_\_\_\_ness * Cardiovascular:* Hyper\_\_\_\_\_, \_\_\_\_\_\_\_artery disease, M\_, \_\_\_\_\_\_tension * Kidneys:* Renal disease, renal \_\_\_\_\_\_ * Feet:* Foot ul\_\_\_\_\_\_, skin in\_\_\_\_\_\_, peripheral n\_\_\_\_\_\_, amp\_\_\_\_\_\_ * Gynecologic/genitourinary:* _______ (candidal infection of the glans penis), c\_\_\_\_\_\_ vaginitis

Answer 125

* Eyes:* Cataracts, diabetic retinopathy, blindness * Cardiovascular:* Hyperlipidemia, coronary artery disease, MI, hypertension * Kidneys:* Renal disease, renal failure * Feet:* Foot ulcers, skin infections, peripheral neuropathy, amputation * Gynecologic/genitourinary:* Balanitis (candidal infection of the glans penis), candidal vaginitis

Question 126

Primary Prevention of Diabetes *For individuals at high risk of type 2 DM* Encourage how much weight loss? How much exercise? Increase in dietary (2)

Answer 126

Encourage weight loss (7% of body weight) Regular physical activity 150min/week Increase dietary fiber and whole grains

Question 127

Solving an Insulin Related Question The nurse practitioner certification exams are based on the primary care model of care. In general, it is not necessary to memorize specific doses. Keep in mind some broad concepts, such as the peak and duration of each type of insulin. For example: Rapid-acting insulin covers = Regular insulin lasts = NPH insulin lasts = Lantus is =

Answer 127

Rapid-acting insulin covers “one meal at a time” Regular insulin lasts “from meal to meal” NPH insulin lasts “from breakfast to dinner” Lantus is “once a day”

Question 128

**Case Scenario** ## Footnote A patient with type 1 DM is on regular insulin and NPH insulin (not premixed but separate) injected twice a day. The first dose is injected before breakfast, and the second dose is injected at bedtime. The blood sugar results from the patient’s diary (fasting, before lunch, dinner, and bedtime) show that the lunchtime values are higher than normal. *Which insulin dose should be increased or decreased?*

Answer 128

In this case, the NPH component of the morning dose should be increased. Regular insulin peaks between breakfast and lunch (most of it is gone by lunchtime). In contrast, NPH insulin peaks between 6 and 14 hours. Therefore, it will cover the postprandial spike after lunch.

Question 129

Exam Tips First-line medication for type 2 DM is **(1)** * If patient on metformin 500 mg daily and A1C is high (\>7%), increase dose to? * If A1C is still high (\>7%) and on metformin 500 mg BID, increase dose to? * If taking maximum dose of metformin (1 g BID), can use several drug classes with it such as a * **(1)** like glipizide (Glucotrol XL) 5 mg PO daily (do not exceed maximum dose of glipizide 20 mg/day) * **(1)** (Januvia, Onglyza) * **(1)** (Actos), others.

Answer 129

First-line medication for type 2 DM is **metformin (Glucophage)**. * If patient on metformin 500 mg daily and A1C is high (\>7%), increase dose to metformin 500 mg BID. * If A1C is still high (\>7%) and on metformin 500 mg BID, increase dose to metformin 1,000 mg BID (or 1 g BID). * If taking maximum dose of metformin (1 g BID), can use several drug classes with it such as a * **Sulfonylurea** like glipizide (Glucotrol XL) 5 mg PO daily (do not exceed maximum dose of glipizide 20 mg/day) * **DPP-4 inhibitor** (Januvia, Onglyza) * **TZDs (Actos)**, others.

Question 130

Exam Tips At what A1C do you need to start on basal insulin? HbA1C is the average blood glucose level over how long? Important contraindication of Pioglitazone (Actos) = **(1)** foot and ankle is more common in diabetics.

Answer 130

If a patient’s A1C is ≥9, start on basal insulin. Or if on two oral drugs and A1C is ≥9, start on basal insulin. Hemoglobin A1C is the average blood glucose level in previous 3 months (12 weeks). Pioglitazone (Actos) can cause water retention, which may precipitate CHF. Contraindicated if history of heart failure or NYHA class III or IV (moderate to severe heart failure). Charcot’s foot and ankle is more common in diabetics.

Question 131

Exam Tips _Microvascular_ complications of diabetes are (3) _Macrovascular_ complications are (3) _Diabetic Retinopathy_ findings are (4) _Hypertensive retinopathy_ findings are (2) (Photographs of fundi appear on the exam. Search for photographs online)

Answer 131

Microvascular complications of diabetes are retinopathy, nephropathy, and neuropathy. Macrovascular complications are coronary artery disease, peripheral arterial disease, and stroke. _Diabetic Retinopathy_ findings are **cotton-wool (soft exudates), neovascularization, microaneurysms with dot, and blot hemorrhage.** _Hypertensive retinopathy_ findings are silver **wire/copper wire arterioles, arteriovenous nicking.** (Photographs of fundi appear on the exam. Search for photographs online, learn what cotton wool spots look like)

Question 132

Exam Tips Lid Lag is a symptom of? Alopecia on outer third of eyebrow and myxedema are symptoms of? When should a patient disconnect from their insulin pump?

Answer 132

Lid lag is a symptom of Graves’ ophthalmopathy (hyperthyroidism). Alopecia of outer one-third of eyebrow and myxedema are symptoms of hypothyroidism. Tell patient to disconnect insulin pump if swimming, bathing, or showering. Certain sports (e.g., wrestling) require that an insulin pump be disconnected during activity.

Question 133

Clinical Pearls People with subclinical and overt hyperthyroidism are at higher risk of bone **(1)** and cardiac **(1)** complications. New-onset atrial fibrillation, check (1). * Keep TSH between **\_\_\_** and ____ mU/L as goal for thyroid hormone supplementation. Diabetics are at higher risk for (2) ophthalmologic conditions In morbidly obese patients, _________ surgery can result in remission of type 2 diabetes.

Answer 133

People with subclinical and overt hyperthyroidism are at higher risk of bone (osteopenia/osteoporosis) and cardiac (atrial fibrillation) complications. New-onset atrial fibrillation, check TSH. - Keep TSH between 1.0 and 4.0 mU/L as goal for thyroid hormone supplementation. Diabetics are at higher risk for cataracts and glaucoma. In morbidly obese patients, bariatric surgery can result in remission of type 2 diabetes.

Question 134

Exam Tips Subclinical Hypothyroidism TSH and T4 level = If patient has elevated TSH (\>5.0 mU/L), workup needed for _______ (e.g., order(2)). Start older patients at ____ dose of Synthroid (12.5–25 mcg/day) and gradually increase to avoid adverse ______ effects from overstimulation (palpitations, angina, MI). Patient with normal free T4 but with elevated TSH—do you treat? what should you do?

Answer 134

Subclinical Hypothyroidism TSH and T4 level = TSH elevated, normal free T4 If patient has elevated TSH (\>5.0 mU/L), workup needed for hypothyroidism (e.g., order TSH, free T4). Start older patients at low dose of Synthroid (12.5–25 mcg/day) and gradually increase to avoid adverse cardiac effects from overstimulation (palpitations, angina, MI). Patient with normal free T4 but with elevated TSH—do not treat (subclinical hypothyroidism). Recheck TSH in about 6 months.

Question 135

Exam Tips ## Footnote When do you recheck TSH to monitor treatment response? If TSH is 0.05 to 5.0 mU/L, it is within normal limits and the patient is at the right dose (Synthroid). Radioactive iodine treatment results in \_\_\_\_\_thyroidism for life. Needs (1) for life. If TSH is suppressed (TSH \<0.05 mU/L), workup needed for \_\_\_\_\_thyroidism. Chronic amenorrhea and hypermetabolism result in \_\_\_\_\_\_. Supplement with c\_\_\_\_\_ and with ______ 1,200 mg; engage in (1) exercises.

Answer 135

Check TSH every 6 to 8 weeks (do not order earlier than 6 weeks) to monitor treatment response. If TSH is 0.05 to 5.0 mU/L, it is within normal limits and the patient is at the right dose (Synthroid). Radioactive iodine treatment results in hypothyroidism for life. Supplement with thyroid hormone for life. If TSH is suppressed (TSH \<0.05 mU/L), workup needed for hyperthyroidism. Chronic amenorrhea and hypermetabolism result in osteoporosis. Supplement with calcium and with vitamin D 1,200 mg; engage in weight-bearing exercises.

Question 136

Clinical Pearls ## Footnote Many patients with subclinical hypothyroidism will eventually develop? Advise patient to _____ Synthroid tablets with teeth before swallowing with ____ for better absorption. These tablets are _____ T4 (levothyroxine). Alternative medicine practitioners are more likely to prescribe _____ thyroid tablets (desiccated thyroid glands from pigs), which contain natural T3 and T4 for hypothyroidism. All \_\_\_\_thyroid patients should be referred to an _______ as soon as possible.

Answer 136

Many patients with subclinical hypothyroidism will eventually develop overt hypothyroidism. Advise patient to crush Synthroid tablets with teeth before swallowing with water for better absorption. These tablets are synthetic T4 (levothyroxine). Alternative medicine practitioners are more likely to prescribe Armour thyroid tablets (desiccated thyroid glands from pigs), which contain natural T3 and T4 for hypothyroidism. All hyperthyroid patients should be referred to an endocrinologist as soon as possible.