0
Q
3 main hormone families and solubilities
A
Amine derived (water soluble) Peptide hormones (water soluble) Lipid phospholipid hormones (water insoluble)
1
Q
What we need from this type of system
5 + eg
A
Specificity Only specific receptors High affinity for hormone Integrated amplification system Protective transport system eg albumin
2
Q
Amine derived eg
A
Tyrosine
Histadine
Trypophane
3
Q
Peptide hormone eg
A
TRH
Insulin
LH
4
Q
Lipid hormones eg
A
Prostaglandins
Testosterone
5
Q
Hormone receptor interaction
A
Defined by Kd
Dissociation constant
6
Q
Conc of hormone is determined by 3 factors
A
Rate of release
Rate of delivery
Rate of degradation and elimination
7
Q
Rate of release
A
Synthesis and secretion
Controlled by positive and negative feedback
8
Q
Rate of delivery
A
High blood flow delivers more hormones
9
Q
Rate of degradation
A
Short half life
Rapid removal
10
Q
Hydrophilic hormone receptors.
A
Cell surface membrane Channel linked receptors Secondary messengers: Enzyme receptors Tyrosine kinase G-protein linked
11
Q
Hydrophobic receptors
A
Cytoplasmic receptors
