Etomidate (Amidate)

Question 1

Drug Classification

Answer 1

Sedative/Hypnotic

Question 2

Mechanism of Action

Answer 2

Depresses reticular activating system of the brain and potentiates GABA
-> causes sedation

Question 3

Pharmacokinetics

Answer 3

• Onset of Action- 10-20sec
• Peak Effects- <1min
• Duration of Effects- 3-5min
• Half-Life- 30-70min

Question 4

Indications/Field Use

Answer 4

Induction Agent for RSI

Question 5

Contraindications

Answer 5

Hypersensitivity

Question 6

Side Effects/Adverse Reactions

Answer 6

Myoclonic skeletal muscle movement, apnea, hyperventilation/hypoventilation, laryngospasm, HTN/hypotension, Bradycardia/tachycardia, N&V

Question 7

Dose

Answer 7

Adult:
0.3mg/kg IV/IO over 15-30 seconds

Pedi:
0.3mg/kg IV/IO over 15-30 seconds

Question 8

Precautions

Answer 8

Consider alternate sedative in patients with severe asthma

Question 9

Drug-Drug Interactions

Answer 9

May prolong respiratory depression and apnea with Verapamil