Exam questions-Milner

Question 1

T/F: macrophages play no role in the body’s immune response to cancer

Answer 1

False

Question 2

T/F: With MHC restricted tumor antigen presentation, lack of inflammation and lack of costimulatory molecule expression can lead to tolerance

Answer 2

True

Question 3

Killing of cancer cells in the body by NK-cells is thought to be primarily mediated by

Answer 3

CD95/CD95 ligand receptor interactions

Question 4

What are some reasons for failure of the immune response in cancer patients

Answer 4

Development of tolerance
Down regulation of MHC-1 receptors on cancers
Suppressor cells
Blocking antibodies