Haldane's Rule

Question 1

three requirements for haldane’s rule to apply

Answer 1

x linked recessive

reduced fitness (genetic lethal)

-negative relevant family history

Question 2

what are excluded?

Answer 2

x linked diseases caused by dynamic mutations, such as fragile x

Question 3

what does haldane’s rule explain?

Answer 3

why not all mothers of x-linked recessive disorder sons are carriers themselves

Question 4

classic example?

Answer 4

DMD where fitness = 0

Question 5

the proportion of new mutations amoung affected males will be…

Answer 5

1/3, and only 2/3 of the mothers will be carriers

only applies if ftiness is low (0)

u must equal v, aka, female and male mutaton rate must be the same