Hematopathology- Erin Wright

Question 1

heme=

Answer 1

blood

Question 2

penia=

Answer 2

deficiency

Question 3

myelo=

Answer 3

bone marrow

Question 4

What are the types of CBCs one can order?

Answer 4

• CBC with no differential
• CBC with automatic differential
• CBC with manual differential.

Question 5

How does a CBC w/ automatic diff. differ from a CBC w/ manual diff.?

Answer 5

• Automatic diff: A computer is reading it and giving you a report
• Manual diff: A lab tech is manually counting the cells.

Question 6

What is the most important lab when discussing and evaluating a disease of hematologic nature?

Answer 6

CBC

Question 7

What is a WBC count?

Answer 7

total # of leukocytes

Question 8

What are leukocytes?

Answer 8

WBCs:

• Lymphocytes
• Monocytes
• Eosinophils
• Basophils
• Neutrophils

Question 9

What is the numeric relationship between hematocrit and hemoglobin?

Answer 9

Hematocrit is 3x the value of hemoglobin.

Question 10

CBC: Why are absolute values more helpful than percentage values?

Answer 10

A percentage will tell you the relative nature of the amount of a leukocyte. An absolute count tells you precisely how many of a leukocyte type is present.

Question 11

What can fluid gathered from a bone marrow aspiration do for you?

Answer 11

• Molecular genetics

- Flow cytometry

Question 12

What information can you gather from a bone marrow biopsy?

Answer 12

• Cell constitution

- Represents all cells

Question 13

When comparing a bone marrow aspiration with a biopsy, which provides you with more information?

Answer 13

bone marrow biopsy

Question 14

Define hematopoiesis

Answer 14

blood cell formation

Question 15

Define thrombopoiesis

Answer 15

production of platelets

Question 16

Define erythropoiesis

Answer 16

production of RBCs

Question 17

Define leukopoiesis

Answer 17

production of white cells

Question 18

Hematopoiesis: What is the most basic stem cell?

Answer 18

Multipotent hematopoietic stem cell (hemocytoblast)

Question 19

Hematopoiesis: Hemocytoblasts develop into one of two stem cells?

Answer 19

Myeloid and lymphoid stem cells

Question 20

Hematopoiesis: Myeloid stem cells end up producing what type of cells?

Answer 20

• Platelets
• Erythrocyte
• Basophil
• Neutrophil
• Eosinophil
• Monocyte.

Question 21

Hematopoiesis: Myeloid stem pants evolve into what cells?

Answer 21

• Megakaryoblast
• Proerythroblast
• Myeloblast
• Monoblast

Question 22

Hematopoiesis: Pathway between a myeloid stem cell and a platelet?

Answer 22

• > Megakaryoblast
• -> Megakaryocyte
• -> Platelet

Question 23

Hematopoiesis: Pathway between a myeloid stem cell and an erythrocyte?

Answer 23

• -> Proerythroblast
• -> Reticulocyte
• -> Erythrocyte

Question 24

Hematopoiesis: Pathway between a myeloid stem cell and a monocyte?

Answer 24

• -> Monoblast

- -> Monocyte

Question 25

Hematopoiesis: A myelobast can develop into what types of leukocytes?

Answer 25

- Basophil - Neutrophil - Eosinophil

Question 26

Hematopoiesis: Lymphoid stem cells develop into what final cells?

Answer 26

- Natural killer cell (large granular lymphocyte) - T lymphocytes - B lymphocytes

Question 27

Hematopoiesis: Describe the pathway between a Lymphoid stem cell and a NKC.

Answer 27

Lymphoid stem cell - -> lymphoblast - -> NKC

Question 28

Hematopoiesis: What is another name for an NKC?

Answer 28

Large granular lymphocyte. (these questions are NOT on her test).

Question 29

Hematopoiesis: A lymphoblast can develop into a small lymphocyte which can then evolve into what cells?

Answer 29

- T lymphocytes | - B lymphocytes

Question 30

Thrombopoiesis: Where is thrombopoietin generated?

Answer 30

kidneys and liver

Question 31

Thrombopiesis: Where are old platelets destroyed?

Answer 31

spleen and liver

Question 32

Erythropoesis: When does a reticulocyte become a mature erythrocyte?

Answer 32

- Reticulocyte gets released into circulation | - After 1-2 days becomes a mature erythrocyte

Question 33

Erythropoesis: What does a reticulocyte need to become an erythrocyte?

Answer 33

- Vitamin B12 | - Vitamin B9 (folic acid)