S/Bthal0
Can look just like SS, but would expect CBC to look thalassemic (low mcv, high rbc) and increaes A2
Hemoglobin Barts
Four gamma chains, seen in alpha thal, migrates before the A on capillary electrophoresis
Newborn Screen
Reports hemoglobins in order of greatest concentration: normal would be FA, SS would be FS
Babies produce start to make A2 months later after birth
Sickle Cell Trait
Must ALWAYS have more A than S (41%). Without exception. If more S than A, consider transfused SS vs S/Bthal+