Gilbert’s disease
Bilirubin increases with FASTING
Reduced UDP glucuronyl transferase activity
Courvoisiers law
If the gall bladder is palpable in a jaundiced patient, the cause is unlikely to be gallstones
(pancreatic cancer)
Obstructive jaundice
Pale stools, dark urine
No bilirubin reaches GI tract –> pale stools and ABSENT UROBILINOGEN IN URINE
Reflux of conjugated bilirubin into blood –> into the urine, producing dark urine
Alcoholic hepatitis
Ballooning of liver cells
MALLORY - DENK bodies
Terlipressin
Oesophageal varices