Order of the Phases of Wound Healing
Hemostasis/Coagulation (immediate)
Inflammatory phase (0-5-10 days)
*Cardinal signs: Calor (heat), Rubor (redness), Tumor (swelling), Dolor (pain)
* Wound may sometimes get stuck here
* NEUTROPHILS and MACROPHAGES working
* Bacteria being eaten by PHAGOCYTOSIS
Proliferation/Epithelialization phase (3-20 days)
Remodeling phase (day 9 on 2 yrs)
Hypertrophic
- Raised, Rigid, Red
- stays within the border
Keloid
- 3 R’s
- Grows out of defined area of injury
- If excised, will grow back
Healing by Intention (3 types)
Primary closure: sutures
- acute wounds with minimal tissue loss.
- smooth clean edges. Reapproximated with sutures, stables, or adhesive
- superficial partial-thickness wounds, such as abrasions or blisters also heal this way.
- minimal scarring and heal quickly
Secondary closure: edges can’t be approximated, granulation tissue filling in, scar tissue eminent
- close on their own without superficial closure
- Wound characteristics: significant tissue loss or necrosis, irregular or nonviable wound margins that can’t be reapproximated, infection or debris.
- Typically associated with pathology (DM, ischemic conditions, pressure damage, or inflammatory damage)
- Granulation fills wound bed
- Requires ongoing wound care
- Larger scar
Tertiary/Delayed primary closure: Combo of primary and secondary closure; Wound left open a few days then surgically closed
- Wounds at risk of developing complications such as sepsis or dehiscence
- Temporarily left open until risk factors have been alleviated…then closed by primary intention methods.
Dermis
Epidermis
Where are nerve endings found on the skin?
Hypodermis
Which structure in the epidermis serves as a barrier against fluid, electrolyte, and chemical loss?
stratum corneum
The stratum corneum in the epidermis functions for protection from trauma and microbes, and serves as a barrier to prevent fluid, electrolyte, and chemical loss. The primary function of basal cells, Langerhans cells, and keratinocytes is for epidermal reproduction, immunity, and keratin synthesis respectively.
Which of the following inflammatory mediators is responsible for causing pain in an acute wound?
Prostaglandins
Prostaglandins promote local vasodilation that increases the permeability of local capillaries and induce pain. Prostaglandins are a part of the inflammation cascade following tissue injury.
The process by which epithelial cells die and produce a protective outer layer is called:
Keratinization
Keratinization refers to the development of or conversion to keratin. Keratinocytes are cells located in the epidermal layer that produce keratin, a strong protein that makes up the rigid structure of the skin, hair, and nails.
Arterial Insufficiency Ulcers General Recommendations for treatment
(What to do and not do)
Due to inadequate circulation of oxygenated blood (ischemia)… typically from atherosclerosis.
Venous Insufficiency Ulcers General Recommendations for treatment
from venous insufficiency occur secondary to impaired functioning of the venous system resulting in inadequate circulation and eventual tissue damage and ulceration.
Neuropathic Ulcers General Recommendations for treatment
secondary complication associated with ischemia and neuropathy. Often associated with DM.
Pressure Ulcers General Recommendations for treatment
prolonged or sustained pressure on tissue at levels greater than that of capillary pressure.
Characteristics of Arterial Insufficiency Ulcers
Characteristics of Venous Insufficiency Ulcers
What is a superficial wound and its characteristics
Partial-thickness wound characteristics
Full-thickness wound characteristics
Subcutaneous wound characteristics
What are the stages of pressure injury staging?
Stage 1
Stage 2
Stage 3
Stage 4
Deep Tissue Injury
Unstageable
Stage 1 Pressure Ulcer characteristics
Non-blanchable erythema of intact skin
* Intact skin