Libman-Sacks endocarditis

Question 1

definition

Answer 1

autoimmune inflammation of heart valves that occurs as part of SLE

Question 2

epidemiology

Answer 2

occurs in 50% of pts w/ lupus

usually occurs simultaneously w/ pericarditis

Question 3

gross pathology

Answer 3

small to medium verrucous, berrylike, or flat vegetations
commonly on multiple valves
most commonly mitral and tricuspid, on either or both sides

Question 4

microscopic pathology

Answer 4

necrotic debris
fibrinoid material
degenerating leukocytes, fibroblasts hematoxylin bodies

Question 5

hematoxylin bodies

Answer 5

condensed naked nuclei of dead degenerated gells ingested by phagocytes

Question 6

complications

Answer 6

chronic adhesive pericarditis

NOT emboli from the vegetations