Lipidology Flashcards Preview

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Flashcards in Lipidology Deck (38)
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1

Type I (Chylomicrons)

Contain TGAs
Defect dec'd familial LPL, CII
Skin lesions: eruptive xanthomas

2

Type II (LDL)

Contains: LDL
Defect - dec'd LDL rct's
Skin lesions: Tendon, xanthomas

3

Type III (IDL)

Contains: LDL+TGAs
Defect Abnormal APoE
Skin lesions: Palmar/Tuberous Xanthomas

4

Type IV (VLDL)

Contains: TGAs
Defect dec'd familial LPL, CII
Skin Lesions: Eruptive Xanthomas

5

Type V (VLDL+Chylomicrons)

Contains: TGAs
Defect dec'd familial LPL, CII
Skin Lesions: Eruptive Xanthomas

6

Statins

Primary LDL tx, dec's LDL, inc's TGA, inc'd HDL
S/E - inc'd LFTs, CPK, wt gain
Glucose intolerance

7

Fibric Acid derivatives

Primary TGA tx
Inc'd /N LDL, dec'd TGA, inc'd HDL
S/E Gallstone, hepatoma

8

Bile Acid derivatives

Secondary LDL tx
dec'd LDL, TGAs, inc'd HDL
S/E Bloating, constipation, nausea

9

Nicotinic Acid

Primary HDL, secondary LDL
dec'd LDL, very dec'd TGA, very inc'd HDL
S/E Abd pain, nausesa, flushing, dry skin

10

Ezetimibe

TGA tx, seconary LDL
dec'd LDL, dec'd TGA

11

Apo protien E def

Type III

12

Def of LDL rct's

Type IIa

13

Tendon xanthomas

Type IIa

14

Pancreatitis

Type I, IV, V

15

Pt with LDL 140, TGA 600 -0 fhx hypertriglyceridemia

Fibrinc acid derivative (gemfibrozil, fenofibrate)

16

Which reduces TG of 500 in pt with BMI 30

Losing wegith 5-10%
Defect - C II def - eruptive xanthoma
Tx: Gemfibrozil

17

Palmar Xanthoma

Most likely defect Apo E

18

Chol guidelines

No CAD, 0-1 risk factor LDL <130

19

CAD equivalent risk factors

DM, Vascular dz, multiple risk factors with 10 year framingham >20%

20

Treatment

First line = diet
Goo fats, < 200mg chol
15% calories from protienes
excercise 1hr/day, 5 days/ week
smoking cessagion

21

Reynolds vs Framingham

Reyolds include high sensitivety CRP
Parental h/o MI
Accounts for gender...

22

Pt wants alternative med for prevention of CAD

Omega 3 fatty acid

23

40yo no risk factors for CAD with LDL 175

first diet/excercise

24

Pt with DM likely has...

inc'd LDL, inc'd TGA, dec'd HDL

25

Primary target for therapy in DM pt

LDL

26

62yo F with HTN and DM2 requests advice of CAD risk reduction BP 152/92, A1c 7.6, chol 268, LDL 180, HDL 42

Statin for LDL <100

27

What is initial drug for DM pt with LDL 160, TGA 250, HDL 45

Statin

28

57yo F with MI, quits smoking, changes diet, started on zocor 20 LDL 180 to 140, TGA 350 to 250, HDL 48 wtd?

inc to zocor 40

29

Pt over age 50, LDL 140, CRP more than 2mg - what will dec mortality?

Statin

30

Pt on zocor - 8 wks later with genralized myalgias, CPK 75, AST/ALT 30/40 dz?

statin induced myalgia
Best management - switch to pravastatin