Macrocytic Anemias

Question 1

Vitamin B12

What frees Vit B12 from ingested protein, once it is in the stomach?

What protects Vit B12 from acid destruction?

Where does Vit B12 binds to TF?

Where is the Vit-B12-IF complex absorbed?

Answer 1

Question 2

Causes of Vitamin B12 deficiency?

What is the most common pathological cause of Vit B12 deficiency?

Answer 2

Question 3

Folic acid

Where is it absorbed in the body?

What blocks its absorption?

Answer 3

Question 4

Causes of Folic acid deficiency:

Answer 4

Question 5

Pathogenesis of macrocytic anemia in Vitamin B12 and folate deficiency:

What are the two main pathogenesis events?

What is impared that delayes nuclear maturation?

Is RNA synthesis and protein synthesis affected?

Answer 5

Question 6

Vitamin B12 and folic acid in conversion of homocysteine to methionine and in DNA synthesis

Answer 6

Folic acid deficiency is the most common cause of increased serum homocysteine levels in the United States. Homocysteine acts as an atherogenic factor by converting a stable atherosclerotic plaque into an unstable plaque that leads to thrombosis.

Question 7

Why does Vitamin B12 deficiency leads to neurological issues?

Answer 7

Question 8

Vit B12 clinical findings

Answer 8

Question 9

Vitamin B12 clinical findings

Answer 9

Question 10

Folic Acid clinical findings:

Folic acid deficiency does not shows what?

Answer 10