manipulating cardiovascular function

Question 1

where are the adrenergic receptors located in the cardiovascular system

Answer 1

in the heart: sympathetic nervous system control

Question 2

where are the cholinergic receptors located in the cardiovascular system

Answer 2

in the heart: parasympathetic NS control

Question 3

how do agonists stimulate receptor response

Answer 3

• binding leads to biological response depending on receptor type and receptor localisation
• magnitude of response is determined by the dose and the drug (selective vs. non-selective)

Question 4

describe competitive antagonsists

Answer 4

• bind to receptor in the agonist binding pocket
• surmountable (if you add aneough agonist the antagonist can be overridden)
• reversible
• easier to develop antagonsists than agonsists

Question 5

what is the effect of an antagonists on a dose repsonse curve

Answer 5

specific antagonists cause parallel right shifts to the dose curve indiczting competitive antagonist