MHRA ADDITIONAL/MISCELLANEOUS

Question 1

WHAT IS THE MEANING OF BLACK TRIANGLE SYMBOL?

Answer 1

NEWLY LICENSED MED, requires additional monitoring by the European Medicines Agency
About 5 years retained, longer if need be
ALL reactions? Report through Yellow Card Scheme for drugs w/ black triangle status.

Question 2

DOXYCYCLINE & CONTRACEPTIVES?

Answer 2

Non-enzyme inducing antibacterial so… no additional precautions are advised.

Question 3

875 cards

Question 4

DRUGS IN PREGNANCY CAUTIONED/AVOID? ESSENTIALLY HIGH-RISK DRUGS

Answer 4

ACEi/ARBs
ANTIEPILEPTICS
CYTOTOXICS
LITHIUM
ISOTRETINOIN (retinoids)
WARFARIN

AMINOGLYCOSIDES
ANTIDEPRESSANTS (1st- congenital heart defects 3rd- neonatal withdrawal symptoms, persistent pulmonary hypertension in newborn)
BETA BLOCKERS
BENZODIAZEPINES
NSAIDS
OPIOIDS
PHENOTHIAZINES
TETRACYCLINES

Question 5

IBUPROFEN IN PREGNANCY?

Answer 5

AVOID DURING THIRD TRIMESTER-> risk of closure of fetal ductus arteriosus in utero-> persistent pulmonary hypertension.

Question 6

Codeine during pregnancy?

Answer 6

DON’T USE DURING DELIVERY- RISK OF RESPIRATORY DEPRESSION/WITHDRAWAL SYMPTOMS