MSK/Rheum Pharm Flashcards
(176 cards)
What class of drugs does Acetaminophen belong to?
Analgesic-Antipyretic
What is the MOA for acetaminophen?
CNS
anti-prostaglandin blocks peripheral pain impulse generation; inhibits hypothalamic heat regulation center
When should you use acetaminophen?
Mild to moderate pain relief; fever
What are common SE/ADRs
Edema, rash, increase uric acid, increase ammonia, blood dyscrasias
What are contra-indications for acetaminophen?
Liver disease, hypersensitivity
What are common Dx-Dx interactions with acetaminophen?
Anti-convulsants, decrease APAP concentration, increase warfarin effect
What should you monitor when people are taking acetaminophen?
Liver function; symptom relief; 24H dose
When should pregnant women stop taking acetaminophen?
Third trimester
Should we avoid acetaminophen with alcohol?
Yes. Don’t take it on Old Port nights ya hear!?
What is the max concentration of acetaminophen in peds?
160mg/5mL
Max 24H dose for elderly of acetaminophen?
2 grams
Max 24H dose for adults of acetaminophen?
4 grams
What class of drugs does Tramadol belong to?
Synthetic opioid analgesic
What is the MoA for tramadol?
Opioid analgesic; mu receptor antagonist and inhibits uptake of NE and 5HT–both modify ascending pain pathways
What do you use tramadol?
Moderate to moderately severe pain
What are common SE/ADRs of tramadol?
Flushing, dizziness, somnolence, pruritus, constipation, and seizures
What should we monitor when patients are taking tramadol?
Symptom relief, sedation, fever
What is the maximum dose of tramadol that should be prescribed?
400mg/24H
Dosing: 50-100mg, q4-6h
Reduce dosing if renal or hepatic impairment
Pregnancy category for tramadol?
C
What class of drugs does Ibuprofen belong to?
Traditional NSAIDs/tNSAIDs
What is the MoA for ibuprofen?
Inhibit COX1 and COX2 enzymes reducing PG, prostacyclin, thromboxane
When should we use Ibuprofen?
Pain secondary to inflammation in selected patients
What are common SE/ADRs to ibuprofen?
Nausea, dyspepsia, diarrhea, anorexia, increased BP, fluid retention, increased bleeding (20%)
What is contraindicated for ibuprofen?
Uncontrolled HTN, CKD, HF, CVD, anti-coagulant Tx, Hx GI bleeding or ulcer