PCM Exam 2 > Nephritic Disorders > Flashcards

Nephritic Disorders Flashcards

(40 cards)

Study These Flashcards
1
Q

Nephritic disorders with NORMAL complement levels

A
  • IgA nephropathy/HSP (henoch schonlein purpura)
  • Alport’s
  • SLE I, II, V
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Nephritic disorders with LOW complement levels

A
  • PSGN
  • membranoproliferative glomerulonephritis (MPGN)
  • SLE III, IV
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Episodes of gross hematuria associated with viral respiratory illness or GI illness, is most likely due to ________

A

IgA nephropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

To suspect IgA nephropathy, look for gross hematuria associated with _________

A

Upper respiratory tract infection or GI illness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Describe the presentation of someone with HSP (henoch Schonlein purpura)

A

Child with purpuric rash that starts at feet and goes upward and also has hematuria; it is a type of vasculitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What conditions are associated with IgA nephropathy

A
  • hepatic cirrhosis
  • gluten enteropathy
  • HIV
  • minimal change disease
  • ankylosing spondylitis
  • malignancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The damage of the glomeruli in IgA nephropathy is due to the IgA immune complexes that activate complement found in _______________

A

Glomerular mesangium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are you most likely to see in IF in someone with IgA nephropathy?

A

Dominantly IgA deposits in the mesangium (can also see C3 and can also be seen in subendothelium)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PSGN manifests usually 10 days following _______ and 3 weeks following _______

A

Pharyngitis; impetigo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the complement levels in PSGN?

A

LOW

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Elevated titers of _____________ and __________ and __________ complement are indicative of PSGN

A

Anti-streptolysin O; anti-DNAase B; LOW

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

↑ antistreptolysin O antibody or ↑ anti DNAase B with low complement is most likely indicative of what renal disease?

A

PSGN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Initially in PSGN, there are __________ IC deposits leading to activation of complement with resulting in _________

A

subendothelial; ↓ GFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Subepithelial humps are characteristics for ________

A

PSGN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the rate of resolution of proteinuria in PSGN and why?

A

SLOW; bc IC deposits are cleared very slowly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are some features of PSGN you’d see on light microscopy?

A
  • hypercellular glomeruli
  • proliferation of mesangial, endothelial and epithelial
  • closure of capillarity loops due to proliferation and swelling of endothelial cells +leukocyte infiltration
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

closure of capillary loops is something you see on LM in what renal disease?

18
Q

In IF of someone with PSGN, you will see granular deposits of _______ in the ____________

Study These Flashcards
A

IgG and C3; mesangium and capillary walls

19
Q

MPGN is characterized by: (3)

MPGN is a pattern under light microscopy NOT a diagnosis

Study These Flashcards
A
  • thickening of BM/ reduplicaiton of capillary BM
  • mesangial proliferation
  • infiltration of inflammatory cells
20
Q

“Tram track” appearance

21
Q

What is the difference between type I and type II MPGN?

Study These Flashcards
A

Type I: subendothelial deposits

Type II: dense material deposition along GBM (C3 GN = dense deposit disease only in kids)

22
Q

A patients renal biopsy shows splitting of BM and a “tram track” appearance. What are some underlying diseases that they can have?

Study These Flashcards
A
  • lupus
  • hepC
  • cryoglubinemia
  • endocarditis
  • parasitic infection
  • malignancy
23
Q

Type I MPGN will have complement activation via the _____ pathway and Type II via the ________ pathway

Study These Flashcards
A

Classical; alternative

24
Q

What are some lab indications that would make you think of the diagnosis as dense deposit disease?

Study These Flashcards
A
  • normal C4 levels
  • ↓ C3 elves due to C3 nephritic factor which stabilizes C3bBb convertase allowing for constant degradation of C3
  • child
  • MPGN like pattern (dense deposits of C3 in the GBM)
25
What is the typical presentation of someone with RPGN
Rapid decline in renal function with severe oliguria and pain. (One day normal, next day renal symptoms) MEDICAL EMERGENCY
26
What would you see histologically (LM) in someone with RPGN?
Proliferative GN with prominent “crescent” formation in glomeruli w/ or w/o segmental necrosis
27
Discuss the different type of crescents seen in _________
RPGN; | New to old: cellular → fibrocellular → fibrous (cant treat fibrous because glomeruli already dead)
28
Type I RPGN has ______ staining on IF
Linear; Anti GBM disease: good pastures or idiopathic
29
type 2 RPGN has _____ staining on IF
Granular; Caused by immune complex diseases such as: SLE, post infectious, IgA, HSP
30
Type III has ______ pattern of staining on IF
NO STAINING; Caused by pauci-immune GN which is a form of vasculitis with minimal evidence of HS upon IF staining: wegeners, microscopic PAN, Chung Strauss
31
Which diseases are associated with Type I RPGN?
Anti GBM disease: Goodpastures (linear)
32
What type of disease is associated with Type II RPGN?
Immune complex diseases such as: - SLE - post infectious - IgA - HSP
33
What disease are associated with Type 3 RPGN?
Pauci immune : - Wegners - Chung Strauss - Microscopic PAN
34
SLE (lupus) is an autoimmune disorder of unknown etiology characterized by production of _________ and subsequent immune complex formation leading to chronic inflammation and tissue destruction
Autoantibodies
35
In lupus nephritis, there is an abnormal excess production of antibodies against “endogenous” nuclear antigens such as:
DsDNA, ANA (antinuclear antibody), Sm (anti-Smith), Ro, La
36
What MUST you be able to stain for and see in IF in order to diagnose lupus in a patient?
For all classes of lupus nephritis will have a full house (IgG, IgA, IgM, C1q, C3) MUST HAVE C1Q
37
What is the difference between Class III lupus nephritis and Class IV lupus nephritis?
Class III: FOCAL (< 50% affected) | Class IV: DIFFUSE (> 50% affected)
38
What characterizes classs V lupus nephritis?
Class V is also called membranous lupus nephritis → SUBEPITHELIAL IMMUNE COMPLEX DEPOSITS with diffuse thinking of GBM (presents same as idiopathic membranous)
39
How is the disease activity of a patient with lupus monitored?
Measure: - complement - anti dsDNA antibodies - ESR - C-reactive protein
40
Quickly describe the classes of lupus (6) based on histology and EM:
``` Type I: minimal mesangial Type II: mesangial proliferative Type III: focal segmental proliferative Type IV: diffuse proliferative Type V: membranous Type VI: advanced sclerosing ```
PCM Exam 2
flashcards
Decks in class (32)
# Cards
Brainscape helps you reach your goals faster, through stronger study habits.
© 2026 Bold Learning Solutions. Terms and Conditions