Neurology Drug List Flashcards Preview

Neuro IV > Neurology Drug List > Flashcards

Flashcards in Neurology Drug List Deck (60)
Loading flashcards...
1

Typical D2 Antagonists

Chlorpromazine and Haloperidol
Haloperidol and the "azines"

2

Chlopromazine Side Effects (SE)

Dry mouth (antimuscarinic), orthostatic hypotension (a1 antagonist), and sedation (antimuscarinic and antihistamine). Low potency, but also weight gain and increased risk for diabetes.

3

Halperidol Side Effects (SE)

Extrapyramidal side effects (DA blockade), can cause tardive dyskinesias. Used to tx CNS stimulant psychosis.

4

Atypical D2/5HT Antagonists

Clozapine, Quetiapine, Olanpazine, Risperidone, Aripipazole. All cause weight gain.

5

Clozapine SE

Agranulocytosis. Neuroleptic Malignancy. For pts who are refractive to other drugs.

6

Quetiapine SE

Wt gain and Diabetes; decrease EPS

7

SSRIs

Fluoxetine, Paroxetine, Escitralopam, Setraline, and Citalopram. Wide interpatient variations; wt gain, sexual dysfunction, cognitive blunting, and withdrawal sx.

8

Fluoxetine and Paroxetine

blocks serotonin transporter and P450 inhibitor. Withdrawal sx.

9

Escitralopam

SSRI

10

NDRIs

Bupropion

11

Bupropion

Sedation, and potential for seizures at high doses. At high dose causes anxiety.

12

SNRIs

Venlafaxine

13

Venlafaxine

SNRIs. SE: HTN and anxiety, rapid withdrawal.

14

TCADs (Drugs and Uses)

Declining use; 2nd line agaents, antimuscarinic side effects, CV and seizures in overdose.
Amitriptyline.

15

Amitriptyline

TCADs; 2nd line agents for depression, has antimuscarinic SE. CV problems and seizures in overdose. Also has a sedative action.

16

MAOIs

Phenelzine

17

Phenelzine

SE: postural hypotension, seizure, shock, hyperthermia in overdose, hypertensive crisis with foods high in tyramine, +SSRIs --> serotonin syndrome.

18

Antimanic Agents

Lithium Carbonate*, Carpamazepine, Valproate, Olanzapine, Fluoxetine

19

Lithium Carbonate

Interference with PIP recycling. Enhance 5HT action/ decrease NE and DA effect. Use dependent (greatest activity in most active cells); narrow therapeutic index. Diuretics and NSAIDs will increase lithium levels. Can also cuase hypothyroidism, poluuria, and polydipsia.

20

Sedatives-Hypnotics-Anxiolytics

BDZs, Non-BDZ BDZ Agonists, Barbiturates, Melatonin Receptor Antagonist, Other (Diphenhydramine)

21

BDZs

"Lams and Pams"; sedative (a1) and anxiolysis (a2/a5); need much greater dosage increments to achieve CNS depression, increase margin of safety than compared to BARBs.

22

Flumazenil

BDZ receptor antagonists; used in BDZ overdose to relieve CNS depression.

23

Non-BDZ BDZ Agonists

Zolpidem, Eszopiclone, Zalepon, "Zzz drugs", only acts on a1 GABA receptors.

24

Zolpidem

"Ambien"; mild side effects and no hangover. Decrease sleep latency and nocturnal awakenings.

25

Eszopiclone

Longer half life than zolpedam; next day psychomotor impairment with higher doses (FDA requires lower dose for initiation); used for sleep maintenance.

26

Zalepon

Dizziness, HA, and somnolence. Decrease time for sleep onset.

27

Barbiturates

Phenobarbital.Anticonvulsant effects without severe sedation or effects on mental or motor activity.

28

Phenobarbital

Anticonvulsant effects without severe sedation or effects on mental or motor activity.

29

Alprazopam

rapid po; acute management of anxiety

30

Flurazepam

long half life --> result in daytime sedation.