Oncogenes Flashcards by Abby Frederickson

Q

Oncogenes

A

Gain of function = increased cancer risk

Need to damage only 1 allele

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Q

BCR-ABL

A

CML, ALL

Tyrosine kinase

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Q

Bcl-2

A

Follicular and undifferentiated lymphomas

Anti-apoptotic molecule (inhibits apoptosis)

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Q

BRAF

A

Melanoma

Serine/threonine kinase

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Q

c-kit

A

Gastrointestinal stromal tumor (GIST)

Cytokine receptor (for stem cell factor)

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Q

c-myc

A

Burkitt lymphoma

Transcription factor

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Q

HER2/neu (c-erbB2)

A

Breast, ovarian, gastric carcinomas

Tyrosine kinase

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Q

L-myc

A

Lung tumor

Transcription factor

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Q

N-myc

A

Neuroblastoma

Transcription factor

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Q

RAS

A

Colon, lung, pancreatic cancers

GTPase

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Q

RET

A

MEN 2A and 2B

Tyrosine kinase

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