Pathognomic things

Question 1

Smudge cells on blood film

Answer 1

CLL

Question 2

Auer rods on blood film

Answer 2

AML

Question 3

Hummingbird sign on brain imaging

Answer 3

PSP

Question 4

Hot Cross Bun sign on imaging

Answer 4

Multiple system atrophy
atrophy of putamen, pons, middle cerebellar peduncles, and cerebellum

Question 5

Cortical junction micro haemorrhages

Answer 5

amyloid angiopathy

Question 6

masked facies

Answer 6

seen in Parkinson’s

Question 7

“Rose spots” - faint salmon-colored macules on the trunk and abdomen

Answer 7

typhoid

Question 8

spur cells on blood film

Answer 8

seen in cirrhosis

Question 9

Characteristics of digeorge syndrome

Answer 9

22q11 microdeletion- TBx1 mutation

CATCH22
cardiac abnormalities
abnormal facies
thymic aplasia
cleft palate
hypocalcaemia
22q11 deletion

Question 10

onion skin fibrosis

Answer 10

primary sclerosing cholangitis