Pharma MCQ 8

Question 1

BG Coefficient: Xenon

Answer 1

0.2

Question 2

BG Coefficient: Desflurane

Answer 2

0.42

Question 3

BG Coefficient: N2O

Answer 3

0.47

Question 4

BG Coefficient: Isoflurane

Answer 4

1.4

Question 5

BG Coefficient: Halothane

Answer 5

2.5

Question 6

Which of these have a BG Coefficient > 1?

Xenon, Desflurane, Nitrous Oxide, Isoflurane, Halothane

Answer 6

Isoflurane and Halothane

Question 7

How does thiopental exert its effect on respiration?

Answer 7

Thiopental causes respiratory depression by a direct effect on the respiratory centre in the medulla rather than on peripheral chemoreceptors.

Question 8

Thiopental protein binding?

Answer 8

80%

Question 9

Thiopental metabolism and clearance?

Answer 9

Its action is terminated by redistribution

and hepatic metabolism is SLOW.

Question 10

Resistance to non-depolarising relaxants may be produced by:

1. hypothermia
2. phenytoin
3. lithium
4. hypocalcaemia
5. carbamazepine

Answer 10

Phenytoin and Carbamazepine

Resistance to aminosteroid neuromuscular blockers can occur with chronic medication with anticonvulsants phenytoin and carbamazepine.

Question 11

Which is more potent, lidocaine or ropivocaine?

Answer 11

Ropivocaine is 4 times more potent.

Question 12

Plasma binding cocaine?

Answer 12

98%

Question 13

Plasma binding amethocaine?

Answer 13

75%

Question 14

Prilocaine, ester or amide?

Answer 14

Amide

Question 15

Effect of metabolic products of prilocaine?

Answer 15

O-Toluidine

• allergic reaction
• reduces Hb
• methaemoglobinaemia in high doses

Question 16

Can prilocaine be used for obstetric epidural anaesthetist?

Answer 16

NO, AVOID.

Prilocaine should be avoided for obstetric anaesthesia because fetal haemoglobin is more susceptible to methaemoglobin formation

Question 17

TCA, mechanism of action?

Answer 17

Tricyclic antidepressants have several actions including inhibiting presynaptic re-uptake:

• norepinephrine
• epinephrine
• 5-hydroxytryptamine (serotonin)

but do not affect metabolism per se.

Question 18

How do benzodiazepines effect brain physiology?

Answer 18

Benzodiazepines are relatively lipid soluble and penetrate the blood brain barrier readily.

> > > DOSE RELATED: decrease cerebral blood flow and cerebral oxygen consumption.

Question 19

True or false: Benzo have depressant effects dull after long-term use?

Answer 19

True,

long-term use -> tolerance.

Question 20

ICP in a ventilated patient is increased by which of the following:

1. Desflurane
2. Nitrous oxide
3. Fentanyl
4. Vecuronium
5. Ketamine

Answer 20

Desflurane - vasodilation above MAC 1

Ketamine - increases CBF and ICP