Renal Function Test

Question 1

GLOMERULAR FILTRATION

measures the rate at which kidneys are able to REMOVE filtrable substances in blood

Answer 1

Clearance Test

Question 2

GLOMERULAR FILTRATION

Clearance Test includes (4)

Answer 2

1. Creatinine
2. Cystatin C
3. Radioisotopes
4. B-2 microglobulin

Question 3

GLOMERULAR FILTRATION

Clearance Test Specimen

Answer 3

24 hour Urine

Question 4

GLOMERULAR FILTRATION

Greatest error of Clearance Test

Answer 4

Use of IMPROPERLY TIMED SPECIMEN

Question 5

GLOMERULAR FILTRATION

First Voided urine @7am is included will cause

Answer 5

falsely ELEVATED

Question 6

GLOMERULAR FILTRATION

Last Voided urine @7am is NOT included will cause

Answer 6

Falsely DECREASED

Question 7

GLOMERULAR FILTRATION

single marker that denotes RENAL FAILURE

Answer 7

Creatinine

Question 8

GLOMERULAR FILTRATION

marker for RENAL TUBULAR INTEGRITY

Answer 8

B2-microglobulin

Question 9

GLOMERULAR FILTRATION

Polymer fructose

Answer 9

Inulin

Question 10

GLOMERULAR FILTRATION

Extremely stable ; not a normal body constituent must be INJECTED THROUGH IV

Answer 10

Inulin

Question 11

GLOMERULAR FILTRATION

Small protein (MW 13,359)

Filtered, reabsorbed, broken down by RTC

serum concentration is DIRECTLY RELATED TO GFR

Answer 11

Cystatin C

Question 12

GLOMERULAR FILTRATION

MW 11,800

Dissociates from HLA

Rapidly removed from plasma by Glomerular Filtrate

INVERSELY RELATED TO GFR

Answer 12

B2-microglobulin

Question 13

GLOMERULAR FILTRATION

Kidney disease has DECREASED GFR and ____ B2-Microglobulin

Answer 13

Increased

Question 14

GLOMERULAR FILTRATION

Injecting radionucleotides (125I-iothalamate)

Disappearance of radioactive material in plasma

measure VIABILITY OF KIDNEY TRANSPLANT

Answer 14

Radioisotopes

Question 15

GLOMERULAR FILTRATION

Waste product of muscle metabolism

Answer 15

Creatinine

Question 16

GLOMERULAR FILTRATION

Endogenous substance

Answer 16

Creatinine

Question 17

Normal Creatinine:

Answer 17

120 mL/min

Question 18

GLOMERULAR FILTRATION:

Estimated GFR (eGFR) (2)

Answer 18

1. Cockroft-Gault
2. Modification of Diet in Renal Disease (MDRD)

Question 19

GLOMERULAR FILTRATION:

Results are NOT CORRECTED for body surface area ; woman have 15% lower creatinine clearance

Answer 19

Cockcroft-Gault

Question 20

GLOMERULAR FILTRATION:

Cockcroft-Gault includes factors:

Answer 20

BAGS

1. Body Weight
2. Age
3. Gender
4. Serum Creatinine

Question 21

GLOMERULAR FILTRATION:

Provided more accurate assessment in GFR; does not require patient’s weight

Answer 21

MDRD

Question 22

GLOMERULAR FILTRATION:

MDRD includes factors:

Answer 22

RAGS:

1. Race
2. Age
3. Gender
4. Serum Creatinine

Question 23

GLOMERULAR FILTRATION:

MDRD also includes factors:

Answer 23

1. Serum albumin
2. BUN
3. Race

Question 24

First Function to be affected in RENAL DISEASE

Answer 24

Tubular Reabsorption

Question 25

Tubular Reabsorption uses CONCENTRATION TESTS such as (2)

Answer 25

1. Specific Gravity 2. Osmometry

Question 26

TUBULAR REABSORPTION: most useful screening procedure and quantitative of renal concentrating ability

Answer 26

Specific Gravity

Question 27

TUBULAR REABSORPTION: patients were deprived of fluids for 24 hours before measuring SG (SG 10.26 or higher)

Answer 27

Fishberg Test

Question 28

TUBULAR REABSORPTION: compared volume and specific gravity of day and night

Answer 28

Mosenthal Test

Question 29

TUBULAR REABSORPTION: 1. Quantitative measurement of CONCENTRATING ABILITY 2. Measures only the number of PARTICLES in solution

Answer 29

Osmometry

Question 30

TUBULAR REABSORPTION: Performed for more accurate evaluation of renal concentrating ability

Answer 30

Osmolality

Question 31

TUBULAR REABSORPTION: Measurement of freezing point depression

Answer 31

Freezing point osmeter

Question 32

TUBULAR REABSORPTION: 1 mol of non-ionizing substance dissoved in1 kg of water is known to LOWER freezing point

Answer 32

- 1.86 deg celsius

Question 33

Measure tubular secretion of nonfiltered substances; measured by a substance THAT IS SECRETED

Answer 33

Tubular Secretion and Renal Blood Flow

Question 34

TUBULAR SECRETION: Tests (2)

Answer 34

1. Phenolsulfonpththalein (PSP) dye 2. P-aminohippuric Acid Test (PAH Test)

Question 35

Titratable Acidity and Urinary Ammonia

Answer 35

Tubular Secretion

Question 36

Normal person excretes approximately _____ of titratable acids

Answer 36

70 mEq/day

Question 37

Inability to produce Acidic urine Metabolic acidosis

Answer 37

Renal Tubular Acidosis

Question 38

1. Impaired secretion of hydrogen ions in PROXIMAL convulated tube 2. Defects in Ammonia secretion with DISTAL convulated

Answer 38

Renal Tubular Acidosis