Tablets

Question 1

In dry granulation, what does the roller compaction do?

Answer 1

Increase density by pressing powders under certain pressure

Question 2

What are some limitations of dry granulation?

Answer 2

1. Higher % of fine products = low yield during compression
2. Requires RX w/ cohesive properties
3. Drug loading cannot be high (<40%)

Question 3

What are some limitations of wet granulation?

Answer 3

1. Needs multiple steps such as granulation and drying
2. Not suitable for heat or moisture sensitive RX
3. Hard to control (overwetting or underwetting)

Question 4

What is mottling?

Answer 4

Unequal distribution of color on a tablet

Question 5

What are the In-process controls of tablets?

Answer 5

1. Wt
2. Thickness
3. Hardness
4. Friability
5. Disintegration

Question 6

How is the tablet wt controlled?

Answer 6

1. Determined by volumetric fill of the die cavity

2. 20 tabs are weighed individually and average wt is calculated

Question 7

Tablet thickness can vary with no change in wt due to:

Answer 7

1. Difference in density of granulation
2. Pressure applied
3. Speed of compression

Question 8

What is friability determined by?

Answer 8

Weight loss (<1%)

Question 9

(T/F) In-vitro tablet disintegration test bears a relationship to in-vivo action of tabs

Answer 9

False

Question 10

What are the various ways tablets are coated?

Answer 10

1. Pan coaters
2. Fluid bed coating
3. Compression coating

Question 11

For molded tablets, the tablets are generally a mixture of powdered _____ with or without powdered _____

Answer 11

lactose + sucrose

Question 12

What is the major difference between dry and wet granulation?

Answer 12

Dry- binder used at the beginning

Wet - binder used during wetting period

Question 13

When might it be better to use a capsule form rather than a tablet?

Answer 13

1. RX is oxygen-sensitive

2. RX is bitter tasting