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Flashcards in Traumatic Brain Injury Deck (54)
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1
Q

Of the 1.7 million estimated TBIs occurring each year in the US:

Not everyone goes to the hospital

  1. 7% were emergency department visits
  2. 3% were hospitalizations
  3. 0% were deaths

These numbers do not include TBIs from federal, military, or VA hospitals.

A
2
Q

What is traumatic brain injury?

A

Traumatically induced structural injury or physiological disruption of brain function as a result of external force to the head. New or worsening of at least one of the following clinical signs:

  • Loss of consciousness or decreased consciousness
  • Loss of memory immediately before or after injury
  • Alteration in mental status (confused, disoriented, slow thinking)
  • Neurological deficits
  • Intracranial lesion
3
Q

What is mild traumatic brain injury (MTBI)?

A

Commonly referred to as a concussion, is a brief loss of consciousness or disorientation ranging up to 30 minutes. Though damage may not be visible on an MRI or CAT scan, common symptoms of MTBI include headache, confusion, lightheadedness, dizziness, blurred vision or sluggish pupils, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration or attention.

4
Q

MTBI can have long-term effects, known as:

A

post-concussion syndrome (PCS). Those who suffer from PCS can experience significant changes in cognition and personality.

A concussion is an injury that causes an alteration of the person’s mental status. This is often referred to as having your “bell rung.” The person may be dazed or confused. More serious brain injuries that cause unconsciousness for 30 minutes or more are usually quickly recognized, but concussions may be dismissed and go untreated.

5
Q

What is severe traumatic brain injury?

A

Associated with loss of consciousness for over 30 minutes, or amnesia. Symptoms of Severe TBI include all those of MTBI, as well as headaches that gets worse or do not go away, repeated vomiting or nausea, convulsions or seizures, inability to awaken from sleep, dilation of one or both pupils of the eyes (also known as anisocoria), slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

6
Q

The trauma may cause structural damage or may produce more subtle damage that manifests by altered brain function, without structural damage that can be detected by traditional imaging studies such as MRI CT scans.

TBI varies in severity, traditionally described as mild, moderate and severe. These categories are based on measures of length of unconsciousness and post-traumatic amnesia.

A
7
Q

GCS (Glasgow Coma Scale) is not found that useful in theater for this purpose because it was designed as a prognostic indication for people in a coma which is why it is called a coma scale. The mild rating is not very useful.

The moderate and severe stages are more indicative to the Corpsmen, Medic’s, Dr’s, etc. of what is to be expected

A
8
Q

Describe Mild TBI as defined by the Glasgow Coma Scale

A

AOC (Alteration of Consciousness) less than or equal to 24 hours

LOC (Loss of Consciousness) 0 to 30 minutes

PTA (Post Traumatic Amnesia) less than or equal to 24 hours

Imaging is generally normal.

9
Q

Mild TBI usually mean concussion

It is more commonly thought that people who have a concussion tend to get better, they go back into play, and continue with their lives.

In managing expectations, the term Brain Injury sounds more serious because you are telling the person that their brain is injured. The term concussion sounds less severe and could give people a more optimistic view of recovery which is why we are using the term concussion instead of brain injury.

Remember – TBI and concussion refer to the same injury. It is wise to get into the habit of referring to a traumatic brain injury as a concussion especially when talking with a patient. Then talking to other medical personnel the term TBI is acceptable. It is less unsettling to hear a concussion as opposed to a brain injury.

A
10
Q

Blunt trauma is more common and causes direct brain injury through fractures with underlying tissue laceration or intracranial bleeding. Skull fractures, whether from penetrating or blunt trauma, imply a high degree of force.

Skull fractures are classified by their location, pattern of fracture and whether they are open or closed. Compared with simple linear or comminuted skull fractures, a depressed skull fracture requires a higher degree of energy.

A

Depressed skull fractures often tear underlying dural tissue and directly lacerate or compress brain tissue. Fractures along the temporal bone over the pterion may injure the middle meningeal artery and cause epidural hematoma formation.

Likewise, fractures of bone overlying dural sinuses may injure bridging veins, resulting in subdural hematoma formation.

11
Q

What fractures require a high degree of force owing to the strength and thickness of the bone?

A

Occipital bone or basilar skull fractures

These commonly involve the petrous portion of the temporal bone, damaging middle and inner ear structures and often impair facial, acoustic and vestibular nerve function. These injuries are sometimes associated with a torn dura and CSF otorrhea. The presence of a skull fracture significantly increases the likelihood of an intracranial lesion and one study found the increased risk to be as high as 174 times that of patients without a skull fracture.

12
Q
A
13
Q

What do hematomas or extra-axial fluid collections result in?

A

compressive brain injury due to the presence of blood in an enclosed space and occur in both penetrating and closed head injury.

14
Q

What is an epidural hematoma?

A

Epidural hematomas (EDH) are located blood between the skull and the outer dura mater and typically result from an injury to the temporal bone and middle meningeal artery. However, epidural hematomas may also result from injury to the middle meningeal vein, diploic veins or venous sinuses.

The middle meningeal artery is the source of bleeding in approximately 36% of adult EDH and 18% of pediatric EDH.

15
Q

How do epidural hematomas present?

A

Classically, they present with a head injury and loss of consciousness, followed by a lucid interval. These patients subsequently decompensate due a rapidly expanding hematoma from arterial bleeding.

The classic presentation is only seen in 47% of cases and most patients present either without a loss of consciousness or never regain consciousness after the injury. Approximately 22-56% of patients are comatose on presentation or at the time of surgery.

Pupillary abnormalities are seen in 18-44% of patients.

16
Q

Other common exam findings with epidural hematomas include:

A

focal neurologic deficits, decorticate posturing and seizures.

EDH appears as biconvex or lenticular hyperdense lesions in the temporal region on CT imaging and compresses brain tissue towards the midline. The expanding hematoma in the closed skull results in uncal herniation and rapid death unless surgical intervention is performed.

17
Q

What are subdural hematomas?

A

Subdural hematomas (SDH) are a collection of blood between the dura mater and the pia-arachnoid mater and may result from acute or chronic trauma. SDH may occur with direct or indirect primary brain injury. Acute SDH involves the laceration of brain tissue and superficial cortical veins or avulsion of bridging veins between the cortex and dural sinuses.

18
Q

How do subdural hematomas present?

A

As with EDH, SDH compresses underlying brain tissue, resulting in cerebral edema and hyperemia. The combination of the hematoma and underlying brain edema dramatically increases the intracranial pressure and can trigger activation of the brain injury cascade.

19
Q

What else can cause a subdural hematoma?

A

SDH can also be chronic from distant trauma, particularly in the elderly, and are typically found after symptoms gradually develop over weeks. Elderly patients and alcoholics are particularly prone to SDH because of brain atrophy and increased space between the skull and the cortex. This large space places bridging veins at increased risk for injury.

20
Q

How do subdural hematomas appear on CT?

A

On CT imaging, SDH appear as a hyperdense crescent shaped lesion that may cross suture lines. Chronic SDH may appear hypodense due to the presence of phagocytized iron in the blood.

21
Q

What is a subarachnoid hemorrhage?

A

Direct brain injury may cause bleeding in the intraparenchymal brain tissue or the subarachnoid space, resulting in surrounding cerebral edema and increased intracranial pressure.

22
Q

What causes subarachnoid hemorrhage?

A

Traumatic subarachnoid hemorrhage (SAH) is caused by the disruption of subarachnoid vessels and presents with blood in the cerebral spinal fluid.

Traumatic subarachnoid hemorrhage is common in patients with moderate and severe head injuries with an incidence as high as 33-60%.

23
Q

Patients with traumatic subarachnoid hemorrhage have a significantly increased mortality and morbidity compared with other moderate and severe brain injured patients. They are twice as likely to suffer from death, persistent vegetative state or severe disability. The worse outcome is thought to result from two possible mechanisms. Namely:

A

First, the presence of a traumatic subarachnoid hemorrhage is a marker for increased severity of injury and there is a high association between the presence of a traumatic subarachnoid hemorrhage and other intracranial insults.

In addition, traumatic subarachnoid hemorrhage is associated with cerebral artery vasospasm which worsens cerebral blood flow to surrounding regions, leading to increased ischemia of brain tissue.

24
Q

Initial CT imaging is less sensitive for SAH than CT scans performed at 6-8 hours after the injury, necessitating close neurological observation after admission of moderate and severe head injured patients.

A
25
Q

How is a concussion defined?

A

In terms of what defines concussions you have to have had an event or injury to cause the concussion in the first place.

Second, you need to have an alteration of consciousness (less than 24hrs). You may or may not have been knocked out cold. If you have been knocked out cold then there is better objective evidence that something happened to you. Post traumatic amnesia is then possible and results in new memories not being formulated for less than 24 hours.

Mild TBI is a medical classification but the type of Brain Injury does not necessarily coincide with specific symptoms.

26
Q

Concussion protocol for diagnosis

A

An injury must have occurred AND

The person must have experienced an alteration of consciousness

Alteration of consciousness (AOC) ≤ 24 hours

Loss of consciousness (LOC)s 0-30 minutes

Post-traumatic amnesia (PTA) ≤ 24 hours

Observed signs of neurologic or neuropsychological dysfunction soon after injury can be used to support diagnosis but CANNOT be used to make the diagnosis.

Headache, Dizziness, Irritability, Fatigue

Post-Traumatic Amnesia (PTA) is generally due to TBI and is often transient.

27
Q
A
28
Q

Blast-related TBI:

*IED’s are the number one cause of Brain Injury right now. In fact, very few are being shot when compared to IED explosions.

A
29
Q

Four Types of Blast:

A

Primary Blast: Atmospheric over-pressure followed by under-pressure or vacuum.

Secondary Blast: Objects placed in motion by the blast hitting the service member.

Tertiary Blast: Service member being placed in motion by the blast.

Quaternary Blast: Other injuries from the blast such as burns, crush injuries, toxic fumes.

30
Q

What happens to the brain with trauma?

A

The brain is somewhat gelatin-like and the skull can be compared to a black metal box. With limited space between the gelatin and the black box, additional injuries are possible with the forward and backward movement of the brain during the impact of an injury event. This can result in an effect known as coup-contrecoup.

Coup: This refers to the direct injury site of the brain upon impact with an object. An example is a baseball bat hitting the frontal lobe. The brain hits the front of the skull due to the rapid acceleration from the impact of the bat.

Contrecoup: This refers to the injury site directly opposite the site of impact. With the example of the baseball bat hitting the frontal lobe, the injury site would be located in the occipital lobe. This is because the brain is forced to the back of the skull and damaging tissue.

31
Q

What is diffuse axonal injury (DAI)?

A

Diffuse axonal injury isn’t the result of a blow to the head. Instead, it results from the brain moving back and forth in the skull as a result of acceleration or deceleration, resulting in neuronal components and connections to be destroyed. Automobile accidents, sports-related accidents, violence, falls, and child abuse such as Shaken Baby Syndrome are common causes of diffuse axonal injury.

32
Q

DIA: When acceleration or deceleration causes the brain to move within the skull, axons are disrupted. As tissue slides over tissue, a shearing injury occurs. This causes the lesions that are responsible for unconsciousness, as well as the vegetative state that occurs after a severe head injury.

A diffuse axonal injury also causes brain cells to die, which cause swelling in the brain. This increased pressure in the brain can cause decreased blood flow to the brain, as well as additional injury. The shearing can also release chemicals which can contribute to additional brain injury.

A

Diffuse axonal injury occurs in about half of all severe head traumas, making it one of the most common traumatic brain injuries. It can also occur in moderate and mild brain injury. A diffuse axonal injury falls under the category of a diffuse brain injury. This means that instead of occurring in a specific area, like a focal brain injury, it occurs over a more widespread area. In addition to being one of the most common types of brain injuries, it’s also one of the most devastating. As a matter of fact, severe diffuse axonal injury is one of the leading causes of death in people with traumatic brain injury.

33
Q
A

When the brain turns on itself this causes twisting of axons or shearing of axons. This does not cause immediate breakage but once the damage begins, this leads to degraded enzymes that breakdown the axon of the nerve which causes disconnection.

Damage due to disconnection leads to some form of neurological deficits. That deficit is based on the area in the brain that is damaged.

34
Q

How does a gun shot wound affect the brain?

A

Passage of a bullet can cause laceration (tearing) injuries to the brain, as well as shock waves with cavitation (temporary stretching).

A bullet passing through the brain creates a brief wave effect in the tissue leading to rapidly alternating expansion and contraction of the tissue. This creates an area of disrupted tissue surrounding the path of the bullet. The area of disrupted tissue can be as much as 30 times larger than the missile diameter and can cause injury to parts of the brain a considerable distance from the actual bullet path. Sometimes there are multiple paths of injury in the brain caused by a bullet fragmenting after entering the brain. This could be due to the tearing and shearing of areas as they are pushed away from the path of the bullet or projectile at such high speeds.

35
Q

What is blast exposure?

A

An example of blast exposure is if someone is in an MRAP which hits an IED, a person may feel the blast come through their body even if they are not physically harmed.

-DoD has had reports of people having headaches or coming out of this not being able to walking straight.

(The DoD/BUMED is looking at what is going on in the Brain during these blasts. They are trying to understand if is this a different form of concussion or is it something else. There is more information to come on this topic.)

36
Q

What are the most common post-concussive symptoms?

A

emotional (anxiety, depression, irritability, mood lability)

Physical (HA, dizziness, balance, N/V, fatigue, photophobia, ringing)

cognitive (slowed processing, poor concentration or memory)

37
Q

T or F. Civilian literature shows that if you have had a brain injury (BI) that you are more likely to actually develop PTSD and depression.

A

T

38
Q
A
39
Q

What is the prognosis of a concussion?

A

vast majority who sustain a concussion:

  • Do not require complex medical treatment
  • Improve with no lasting clinical sequelae
  • Recover within hours to days, with a small proportion taking longer
  • Return to play sports or full duty in military

A small percentage may experience persistent symptoms and cognitive deficit for an extended period of time (6-12 months and beyond). It is critical to ensure proper treatment, resolution of injury, and avoidance of repeat concussion

40
Q

T or F. Noxious smells could actually trigger new headaches in people with concussion

A

T.

41
Q
A
42
Q

T or F. Athletes with a history of concussion are 4-6 times more likely to experience another concussion

A

T.

  • High school and collegiate athletes with history of 3 previous concussions increases the risk of repeat concussions 3-fold
  • Athletes with a history of 3+ concussions report significantly more symptoms, lower memory scores at baseline
  • Symptoms following repeat concussion may be more serious and resolve at a slower rate
  • More than 3 also increases severity of future concussions
43
Q

What is Second Impact Syndrome?

A

The reason for early diagnosis/detection in concussions is because of a rare syndrome called Second Impact Syndrome (SIS) (Most High School/Collegiate aged young men are at an increased risk for developing this syndrome)

A person may have a known concussion and are not given enough time to fully recover. Then, the person obtains a second hit to the head and the blood flows into and out of the brain. The brain goes haywire and swells. Deficits result in some cases.

44
Q

What are the risk factors for SIS?

A

The risk factors are Males from 17 to 24, and that the injury happens within 4 days from the concussion.

The military population is mostly in this age range. It is very important to make sure that concussed service members get the rest they need to avoid Secondary Impact from cases in Iraq/Afghanistan.

45
Q

Although a rare complication, “Second Impact Syndrome” can occur if an individual sustains a second concussion before the symptoms of the prior concussion have resolved resulting in a catastrophic neurological injury, which can be fatal.
This condition usually occurs when an athlete, for example, returns to competition and play before symptoms from the first concussion resolve.

A

A second blow to the head, even if it is a minor one, can result in a loss of auto regulation of the brain’s blood supply. Loss of auto regulation leads to brain swelling. This results in increased intracranial pressure and leads to herniation of the brain.

46
Q

The average time from second impact to brainstem failure in SIS is:

A

quite rapid, taking two to five minutes. Once herniation and brainstem compromise occur, ocular movement and respiratory failure are likely to result.

47
Q

What is Chronic Traumatic Encephalopathy?

A

A degenerative disease that effects the brain and is believed to be caused by repeated head trauma resulting in a large accumulation of tau proteins, killing cells in regions responsible for mood, emotions, and executive functioning.

48
Q
A
49
Q
A

These events mandate prompt command & medical evaluations and reporting of exposure of all involved personnel.

50
Q
A
51
Q

How are headaches tx?

A

Acetaminophen – first 2 days after injury

NSAIDs – 2 to 7 days

Triptans – if migrainous features

Avoid narcotics!

52
Q

With headaches lasting beyond one week, may consider HA prevention medication includingTCAs, AEDs, and anti-hypertensives. name some

A

TCAs: amitriptyline, nortriptyline

AEDs: tompamax, depakote

Anti-HTN: propranolol, verapamil

53
Q
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54
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