UTI pharmacology Flashcards Preview

PT2 ID 1-6 > UTI pharmacology > Flashcards

Flashcards in UTI pharmacology Deck (23)
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1

UTI risk factors

-adults 25-29
-women, especially elderly
-sexual activity
-poor hygiene
-dirty pools
-taking baths

2

how do UTIs develop

bacteria usually from anus enters the urethra and swims into bladder where it grows

3

health factors that make people prone to UTI

-dehydration
-structural malformations
-diffculty urination
-catheters

4

symptoms of UTI

-strong urge to urinate
-burning during urination
-low volume at high frequency
-cloudy or red/brown urin
-pelvic or rectal pain
-fever and chills

5

symptom of UTI seen in elderly

demential-like symptoms

6

bacteria responsible for UTI

-E.coli and other Gm- bacilli (85-95%
-staph. sp Gm+ cocci (5-15%)

7

preventative measures for UTI

-empty bladder when urinating
-urinate after sex
-wipe front to back
-drink lots of water
-avoid vaginal irritation
-circumcision
-shower

8

complicated UTI

associated with an underlying medical condition

9

treatment options for uncomplicated lower UTI

-TMP-SMX 160/800 mg bid x 3 days
-nitrofurantoin 100 mg bid x 5 days
-fosfomycin trometamol 1 3g dose

10

treatment options for mild-moderate catheter associated UTI

-cipro
-levofloxacin
-ceftriaxone

11

resistance to nitrofurantoin

generally low and it rarely develops

12

nitrofurantoin use

-uncomplicated UTI
-prevention of recurrent UTI
-long-term suppression

13

nitrofurantoin bioavailability

90%

14

nitrofurantoin elimination

rapidly done by kidney, which is why its great for UTI and nothing else (not enough gets to blood)

15

nitrofurantoin MoA

bacterial reductases form a radical on it which makes it cause DNA damage in the bacteria

16

nitrofurantoin adverse effects

-brown urine
-N/V
-pulmonary toxicities, especially in elderly
-hepatotoxicity
-headache, vertigo, drowsiness

17

nitrofurantoin contraindications

-term pregnant women due to anemia and jaundice
-reduced renal flow
-probenacid

18

methanamine features

-forms formaldehyde in body to kill bacteria
-lots of side effects
-only acts if pH is <5.5
-used for long term prophylaxis

19

phenazopyridine use

-analgesic for symptomatic relief of UTI pain
-don't use more than 48 hours

20

phenazopyridine contraindications

-children
-pregnant women
-renal insufficiency
-hepatitis

21

phenazopyridine side effects

-orange urine
-GI effects
-headache

22

estrogen use in UTI

used to prevent recurrent UTI in elderly women who have had hysterectomy

23

estrogen function in UTI prevention

-reinvigorate tissue reducing spotting and uptake of bacteria
-encourages natural antimicrobial substance production
-makes UT tissue stronger, and more difficult for bacteria to penetrate