Flashcards in Week 3 pregnancy & lactation (everything) Deck (125)
As a class, SSRI's increase the rate of :
cardiac malformations and risk complications
antipsychotic drugs are generally not associated w/:
increased congenital malformations
***is labetalol safe in pregnancy?
*** ACE and ARBs' safe in pregnancy?
should not be given
-can result in:
fetal RF and oligohydramnios
fetal limb contractures
*** Amiodarone safe or not during pregnancy?
safe - most often the agent used
-maternal asthma is common in pregnancy.
have B2 adrenergic receptor agonist and corticosteroids been associated with congenital malformations?
montelukast and zafirlukast
are considered safe
theophylline and aminophylline have no
adverse fetal effects
rivaroxaban and the thrombin inhibitor dabigatran (pradaxa)
are not recommended
they cross the placenta
pregnancy is a hypercoagulable state b/c of relative increases in many:
coag factors and increased venous stasis
pregnant women have 5x the normal risk for
VTE ---> significant cause of maternal death
***postoperative infusions of what drug is best to be avoided due to limited safety data
depression clinics - not for PD
** LMWH is preferred over:
unfractionated heparin b/c it is easy to administer** and does not req monitoring **
phenobarbital and diazepam in infants are considered safe... but what should we be aware of
in infants elimination could be slower and they could accumulate
the shorter half life of UFH means that it is easier to
warfarin is a vitamin K antagonist that can cause an:
embryopathy, especially in 1st trimester
fondaparinux and argatroban (direct thrombin inhibitors) appear to be
safe in pregnancy
** short therm us of aminoglycosides is acceptable but what should be avoided b/c of risk for congenital deafness after 1st trimester?
sulphonamides and nitrofurantoin are safe but avoid
sulfamethoxazole during the first trimester
Tetracyclines should not be administered after what week of pregnancy? Why?
these drugs are so high risk that two forms of Birth Control are recommended when taking:
only a few types of drugs are strongly contraindicated during breastfeeding, these are:
cytotoxic and immunosuppressive drugs
drugs may also affect lactation and some are used therapeutically for
(to improve/reduce lactation)
drugs that increase the secretion of ____ can stimulate milk production.
Transfer of drugs to breast milk occurs mainly by
the rate of passive transfer into breast milk depends on what elements:
1. lipid solubility
2. molecular wt
3. degree of ionization
4. protein binding
Amount of drug in breast milk is a variable fraction of the
what is it that we generally have no concern regarding transfer of in breast milk?