Week 3 pregnancy & lactation (everything) Flashcards Preview

SUM'20 - Advanced Principles > Week 3 pregnancy & lactation (everything) > Flashcards

Flashcards in Week 3 pregnancy & lactation (everything) Deck (125)
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91

As a class, SSRI's increase the rate of :

cardiac malformations and risk complications

92

antipsychotic drugs are generally not associated w/:

increased congenital malformations

93

***is labetalol safe in pregnancy?

typical dose?

yes

5-10mg

94

*** ACE and ARBs' safe in pregnancy?

should not be given

-can result in:
fetal RF and oligohydramnios
fetal limb contractures
craniofacial deformities
pulmonary hypoplasia

95

*** Amiodarone safe or not during pregnancy?

safe - most often the agent used

96

-maternal asthma is common in pregnancy.

have B2 adrenergic receptor agonist and corticosteroids been associated with congenital malformations?

no!

97

montelukast and zafirlukast

are considered safe

98

zileuton is

not recommended

99

theophylline and aminophylline have no

adverse fetal effects

100

rivaroxaban and the thrombin inhibitor dabigatran (pradaxa)

are not recommended

they cross the placenta

101

pregnancy is a hypercoagulable state b/c of relative increases in many:

coag factors and increased venous stasis

102

pregnant women have 5x the normal risk for

VTE ---> significant cause of maternal death

103

***postoperative infusions of what drug is best to be avoided due to limited safety data

ketamine**

depression clinics - not for PD

104

** LMWH is preferred over:

unfractionated heparin b/c it is easy to administer** and does not req monitoring **

105

phenobarbital and diazepam in infants are considered safe... but what should we be aware of

in infants elimination could be slower and they could accumulate

106

the shorter half life of UFH means that it is easier to

reverse

107

warfarin is a vitamin K antagonist that can cause an:

embryopathy, especially in 1st trimester

108

fondaparinux and argatroban (direct thrombin inhibitors) appear to be

safe in pregnancy

109

** short therm us of aminoglycosides is acceptable but what should be avoided b/c of risk for congenital deafness after 1st trimester?

streptomycin

110

sulphonamides and nitrofurantoin are safe but avoid

sulfamethoxazole during the first trimester

111

Tetracyclines should not be administered after what week of pregnancy? Why?

5th week

-teeth darkening

112

these drugs are so high risk that two forms of Birth Control are recommended when taking:

Thalidomide
Ribavirin
Isotretinoin
Acitretin
Valproate

TRIAV

113

only a few types of drugs are strongly contraindicated during breastfeeding, these are:

cytotoxic and immunosuppressive drugs

114

drugs may also affect lactation and some are used therapeutically for

this purpose

(to improve/reduce lactation)

115

drugs that increase the secretion of ____ can stimulate milk production.

prolactin

116

Transfer of drugs to breast milk occurs mainly by

passive diffusion

117

the rate of passive transfer into breast milk depends on what elements:

1. lipid solubility
2. molecular wt
3. degree of ionization
4. protein binding

118

Amount of drug in breast milk is a variable fraction of the

maternal concentration

119

what is it that we generally have no concern regarding transfer of in breast milk?

anesthetic drugs

120

postoperative infusions of what drug is best to be avoided due to limited safety data

ketamine