11.0 Immunology of Pregnancy Flashcards Preview

MedST IB: Human Reproduction (HR) > 11.0 Immunology of Pregnancy > Flashcards

Flashcards in 11.0 Immunology of Pregnancy Deck (14)
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1

What are Medwar's ideas for why mother doesn't 'reject' baby?

1) Immunological immaturity of fetus (not true)
2) Maternal immunosuppression (more like immunomodulation)
3) Placental barrier

2

What are some pathogens that cross placenta?

Toxoplasmosis
Others = Listeria + Zika virus + Parvovirus
Rubella
CMV
HIV/Hepatitis/Herpes
e
Syphilis/Salmonella

3

What percentage of embryos fail to implant?

70%

4

What are the signs of pre-eclampsia?

1) HTN (170/110mmHg)
2) Proteinurea
3) Oedema

5

What are the two sites of interaction between maternal immune cells and trophoblast:

1) Maternal blood is in contact with syncytium (systemic immunity)
- Syncytiotrophoblast cells do not express MHC Class I or II (therefore evade immune recognition)

2) Invading trophoblast is in contact with immune cells (local immunity)
- Lymphocytes/Macrophages/Uterine NK cells

6

What sequelae can occur if trophoblast invasion is not controlled?

1) Placenta accreta
2) Ectopic pregnancy

7

What ligands are expressed on EVT?

HLA-C
- Polymorphic
- Varies from pregnancy to pregnancy

HLA-E - monomorphic
HLA-G - monomorphic

8

What is the main leukocyte found in the decidua?

NK cells
- They can mediate direct contact with EVT cells

9

What receptors are found on NK cells?

1) KIR
2) NKG2A/CD94
3) LILRB1

10

What chromosome is the HLA-C locus found on?

Chromosome 6

11

What are the two groups for HLA-C?

C1 - No problems

C2- can cause inhibition of NK cell function if interacts with KIR haplotype A

12

What chromosome is the KIR locus found on?

Chromosome 19

13

What are the two groups for KIR?

Haplotype A
- Can only respond to HLA-C with inhibition
- Haplotype A + C2 = problems (PE/FGR/RM)

Haplotype B
- Protective when interacting with C2

14

Draw a table of KIR- HLA-C interactions:

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