B Cell Immunity Flashcards

1
Q

What are the 3 kinds of B cells?

A

B-1 Cells
Conventional B-2 Cells
Marginal Zone B Cells

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2
Q

Where does antigen independent development occur?

A

Bone Marrow

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3
Q

Where does antigen dependent development occur?

A

Outside of the bone marrow

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4
Q

Where and when are B-1 cells made?

A

B-1 cells - made in the fetal liver and only made at that time and they self-renew

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5
Q

Where are marginal zone B cells made?

A

Spleen

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6
Q

What do B-1 and marginal zone B cells generally respond to?

A

Carbohydrate antigens

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7
Q

What B cells do not need T cell help?

A

MZ B cells and B-1 don’t need T cell help and don’t have memory which is why they are referred to as innate-like cells

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8
Q

How does dose affect the immunogen response?

A

Need minimum dose to trigger antibody formation

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9
Q

What size antigens are the most immunogenic?

A

Larger antigens

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10
Q

What is an example of a small antigen that is not strongly immunogenic?

A

Insulin

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11
Q

What are the 2 signals required for B cell activation?

A
  1. Presentation of antigen via MHC Class II

2. Signal from a T cell (CD40-CD40L)

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12
Q

How does affinity maturation occurs?

A

Somatic hypermutation to increase the affinity of B cells

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13
Q

What are the events occurring in the germinal center?

A
  • Somatic hypermutation
  • Class switch recombination
  • Development of memory B cells and plasma cells
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14
Q

How are high affinity B cells selected for?

A

By the T cells

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15
Q

What is the function of follicular dendritic cells?

A

Antigen lies on the follicular dendritic cell surface so B cells can see the antigen and take it up and present that to a T cell.

FDC are not APCs

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16
Q

How does a T cell independent response differ (as in MZ B cells and B-1 cells)?

A

Responds to carbohydrates and does not form a germinal center and is only IgM