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Endo/Repro > Wk3 Uterine drugs > Flashcards

Wk3 Uterine drugs Flashcards

1
Q

posterior pituitary

induces labor

reduces postpartum bleeding

releases milk

A

oxytocin

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2
Q

3 prostaglandins that induce labor

A

dinoPROSTone

dinoPROST

misoPROSTol

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3
Q

reduces post partum uterine bleeding

NEVER given to induce labor

A

ergonovine

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4
Q

B2 agonist

smooth muscle relaxant

A

Terbutaline

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5
Q

Competes with Ca2+

smooth muscle relaxant?

A

Mag sulfate

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6
Q

oxytocin receptor antagonist

smooth muscle relaxant

A

Atosiban

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7
Q

NSAID that prevents uterine contraction

A

indomethacin

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8
Q

Any dug used to suppress uterine smooth muscle contractions and thereby suppress labor

A

Tocolytics

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9
Q

SM receptor pathway for contraction:

A

Gq –> PLC –> IP3 –> increased Ca2+

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10
Q

SM receptor pathway for relaxation:

A

Gs –> increased cAMP

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11
Q

Oxytocin receptor locations (3):

A
  1. myoepithial cells in mamary glands
  2. pregnant myometrium
  3. CNS
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12
Q

When during pregnancy is oxytocin effective?

A

third trimester only

**increased receptors

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13
Q

Can oxytocin be given orally?

A

nope

it’s a peptide

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14
Q

Drug of choice for labor induction:

A

oxytocin

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15
Q

Oxytocin risks…

A

slide 16

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16
Q

contracts uterus and produces hyperalgesia

A

PGE2

17
Q

natural PGE

A

dinoPROSTone

18
Q

synthetic PGE

A

misoPROSTol

**can be used as abortifacent

19
Q

natural PGF2alpha

A

dinoPROST

20
Q

PGF2alpha given IM

A

carboPROST

21
Q

act via alpha adrenergic receptors, dopaminergic, and 5HT2’s

induced contraction –> control post partum bleeding

NOT for induction

A

ergometrine = ergonovine

22
Q

B2 agonist to prevent contraction:

A

Terbutaline

23
Q

B2 pathway for SM relaxation

A

activates AC —> increased cAMP

24
Q

competes with Ca2+ –> relaxes SM

prevent seizures due to eclampsia

A

Mag sulfate

25
Q

receptor pathway block by oxytocin receptor antagonist:

What’s the drug?

A

inhibits IP3 —> decreased Ca2+

Atosiban

**increased fetal mortality

26
Q

short term delay in labor

non-selective COX inhibitor

A

indomethacin

27
Q

Tocolytic summary on

A

slide 31

28
Q

PGF2a and oxytocin receptor?

A

Gq

**both increase IP3 –> increase Ca2+

Endo/Repro (46 decks)

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