Vitamin B12 deficiency (neuropathy)

Question 1

Aetiologies?

Answer 1

Dietary deficiency or lack of gastric intrinsic factor

Question 2

Pathology?

Answer 2

Demyelination

Question 3

Signs and symptoms?

Answer 3

Insidious onset where symptoms begin peripherally and move centrally
Spinal cord involvement indicated by UMN signs

Question 4

Investigations and Findings?

Answer 4

B12 serum tests - deficient

Intrinsic factor - deficient

Question 5

Management?

Answer 5

B12 supplementation