Schizophrenia - Burton Flashcards

1
Q

Schneider’s first rank symptoms of schizophrenia?

A

Auditory hallucinations - Third person, running commentary, thought echo

Delusions of thought control - Thought insertion, thought withdrawal, thought broadcasting

Delusions of control - Passivity of affect, volition and impulses, somatic passivity

Delusional perception

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2
Q

What is passivity of volition, affect and impulses?

A

The patient’s volition, affect, and impulses are under the control of an external agency.

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3
Q

What is somatic passivity?

A

The patient’s bodily sensations are under the control of an external agency?

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4
Q

What is delusional perception?

A

The patient attributes delusional significance to normal percepts.

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5
Q

What are the three groups of symptoms present in schizophrenia?

A

Positive symptoms
Disorganised symptoms
Negative symptoms

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6
Q

What are the positive symptoms of schizophrenia?

A

Delusions

Hallucinations

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7
Q

What are the disorganised symptoms of schizophrenia?

A

Disorganised thinking/speech
Disorganised behavious
Inappropriate affect

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8
Q

What are the negative symptoms of schizophrenia? (7 A’s)

A
Affective flattening
Apathy
Avolition (poverty of motivation)
Anergia
Anhedonia
Alogia (poverty of speech)
Asociality
Attentional impairment
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9
Q

What symptoms are prominent in the acute phase of schizophrenia?

A

Positive symptoms come to the fore, whereas cognitive and negative symptoms sink into the background. Antipsychotic started at this point.

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10
Q

In some cases onset of schizophrenia can be preceded by what phase and what are the symptoms?

A

Prodromal phase

Subtle and non-specific abnormalities or oddities in language, cognition, and behaviour that may be mistaken for depression or normal teen behaviour, associated with loss of function.

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11
Q

As the acute phase remits the chronic phase starts, what symptoms are present here?

A

Cognitive and negative symptoms start to dominate the picture. Can last for a period of several months or even several years.

This phase may be punctuated with relapses into a state resembling the acute phase.

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12
Q

What can cause relapses into a state resembling the acute phase from the chronic phase?

A

Sudden reduction or discontinuation of antipsychotic medication, substance misuse, or a stressful life event.

There may be no identifiable triggers in some cases.

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13
Q

How long should you have schizophrenic symptoms for a diagnosis of schizophrenia and what would we describe it as if it were less?

A

Symptoms should have been present for most of the time during a period of one month or more.

If present for less than one month, a diagnosis of acute schizophrenia-like psychotic disorder should be made.

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14
Q

What are the symptoms of schizophrenia in the ICD 10?

A

A) Thought echo, thought insertion or withdrawal, thought broadcasting.
B) Delusions of control, influence, passivity; delusional perception.
C) Hallucinatory voices of running commentary, third-person discussion, or other types of voices coming from some part of the body.
D) Persistent delusions of other kinds that are culturally inappropriate and completely impossible.
E) Persistent hallucinations in any modality if accompanied by fleeting or half-formed delusions that are not affective delusions, or by persistent over-valued ideas, or if occurring every day for months on end.
F) Breaks in the train of thought resulting in incoherence, irrelevant speech, or neologisms.
G) Catatonic behaviour such as excitement, posturing, waxy flexibility, negativism, mutism, and stupor.
H) Negative symptoms.
I) Significant and consistent change in overall quality of some aspects of personal behaviour, manifest as loss of interest, aimlessness, idleness, a self-absorbed attitude, and social withdrawal.

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15
Q

How many of the ICD 10 symptoms do you need to have to make a diagnosis of schizophrenia?

A

A minimum of one very clear symptom (and usually two or more if symptoms are less clear-cut) from groups (A) to (D)

Or symptoms from at least two of the groups (E) to (I)

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16
Q

What are the 7 different types of schizophrenia?

A
Paranoid schizophrenia
Hebephrenic schizophrenia
Catatonic shizophrenia
Undifferentiated schizophrenia
Post-schizophrenic depression
Residual schizophrenia
Simple schizophrenia
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17
Q

What is paranoid schizophrenia, what is the onset?

A

The commonest type. Stable, often paranoid, delusions, usually accompanied by hallucinations and perceptual disturbances. Onset tends to be later than hebephrenic or catatonic schizophrenia, and the course may be either episodic or chronic.

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18
Q

What is hebephrenic schizophrenia what is the onset?

A

Marked by prominent affective changes. Mood is inappropriate and often accompanied by giggling or self-satisfied, self-absorbed smiling, or by a lofty manner, grimaces, mannerisms, prank, hypochondriacal complaints, and reiterated phrases.

Thought is disorganised and speech rambling and incoherent. Behaviour is characteristically aimless and empty of purpose.

Normally diagnosed for the first time in adolescents or young adults, and has a poor prognosis owing to rapid development of negative symptoms.

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19
Q

What is catatonic schizophrenia?

A

Diagnosed in the presence of prominent psychomotor disturbances that may alternate between extremes such as hyperkinesis and stupor, and automatic obedience and negativism.

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20
Q

What is undifferentiated schizophrenia?

A

Conditions that meet the general diagnostic criteria for schizophrenia but don’t conform to any of the above subtypes, or exhibiting features of more than one of them without any predominating.

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21
Q

What is post-schizophrenic depression?

A

Diagnosis can only be made if the patient had a schizophrenic illness in the past 12 months, and if some schizophrenic symptoms are still present although no longer dominating the clinical picture. Depressive symptoms must independently fulfil the diagnostic criteria for a depressive episode.

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22
Q

What is residual schizophrenia?

A

For a diagnosis, must have been a clear progression from an early stage (of one or more episodes with psychotic symptoms that meet the general criteria for schizophrenia) to a later stage characterised by long-term negative symptoms.

This later stage should already have lasted for at least one year, and conditions such as dementia, chronic depression, or institutionalisation should have been excluded.

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23
Q

What is simple schizophrenia?

A

Characterised by the insidious but progressive development of oddities of conduct, an inability to meet the demands of society, and a decline in total performance. The characteristic negative symptoms of residual schizophrenia develop without being preceded by over positive or psychotic symptoms.

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24
Q

Which of the different types of schizophrenia tend to be dominated by positive symptoms, which by negative symptoms and which by disorganised symptoms?

A

Positive – Paranoid
Negative – Simple
Disorganised – Hebephrenic

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25
Q

What are some important psychiatric differentials for schizophrenia?

A
Drug-induced psychotic disorder
Schizoaffective disorder
Depressive psychosis
Manic psychosis
Puerperal psychosis
Personality disorder
26
Q

What are some important organic differentials for schizophrenia?

A

Delirium
Dementia
Stroke
Temporal lobe epilepsy
CNS infections (AIDS, neurosyphilis, herpes encephalitis)
Other neuro conditions (head trauma, brain tumour, huntington’s, wilson’s disease)
Endocrine disorders, especially Cushing’s syndrome
Metabolic disorders, especially B12 deficiency and porphyria
Autoimmune disorders, especially SLE

27
Q

What is the prevalence of schizophrenia?

A

Lifetime prevalence: 1%

Point prevalence: 0.4%

28
Q

What is the sex ratio of schizophrenia?

A

1:1

But presents earlier in men and affects them more severely.

29
Q

What is the age of onset of schizophrenia?

A

Any age but the syndrome is rare in childhood and early adolescence and uncommon after 45.

Mean age of onset in males: 28
Mean age of onset in females: 32

30
Q

What are the geographical affects on schizophrenia?

A

Prevalence and severity tends to be greater in urban areas,

Prevalence also seems to be higher in immigrants, especially 2ng gen. afro-caribbean immigrants to the UK (10x increase)

31
Q

How does seasonality of birth affect schizophrenia?

A

Lifetime prevalence of schizophrenia is increased by about 5-10% if born from January to April in northern hemisphere and July to September in southern hemisphere. (Possible viral aetiology)

32
Q

What are the genetic factors that affect schizophrenia?

A

Concordance rate of about 50% in monozygotic twins, strong genetic effect.

33
Q

What environmental factors can affect schizophrenia?

A

Developmental factors
Life events and background stressors
Expressed emotion
Cannabis and other drugs

34
Q

How much more likely are you to develop schizophrenia if you smoke cannabis?

A

6 times.

35
Q

What investigations should be performed before diagnosing schizophrenia?

A
Full physical (including neurological) examination
Serum or urine drug screen
Liver, renal and thyroid function tests
Full blood count
Fasting blood glucose (or HbA1c)
Lipids
Brain imaging (potentially)
36
Q

What is first line treatment for schizophrenia?

A

Antipsychotics

37
Q

What are the therapeutic and adverse effects of antidopaminergic action?

A

Therapeutic: improvement in positive symptoms

Adverse: EPSEs, negative symptoms, hyperprolactinaemia, neuroleptic malignant syndrome, weight gain

38
Q

What are the therapeutic and adverse effects of sertonergic action?

A

Therapeutic: Possibly small improvement in affective symptoms and negative symptoms.

Adverse: Anxiety, insomnia, change in appetite leading to weight gain, hypercholestorlaemia, diabetes

39
Q

What are the adverse effects of antihistaminergic action?

A

Sedation, weight gain

40
Q

What are the adverse effects of anti-adrenergic action?

A

Postural hypotension, tachycardia, ejaculatory failure

41
Q

What are the adverse effects of anticholinergic action?

A

Dry mouth, blurred vision,glaucoma,constipation, urinary retention.

42
Q

What are the four aspects of extrapyramidal side-effects?

A

Acute dystonias
Akathisia
Parkinsons-like-symptoms
Tardive dyskinesia

43
Q

What are acute dystonias?

A

Often painful spastic contraction of certain muscles or muscle groups (most commonly neck, eyes, and trunk)

E.g tongue protrusion, grimacing, torticollis.

Treatment: anticholinergics

44
Q

What is akathisia?

A

Distressing feeling of inner restlessness manifested by fidgety leg movements, shuffling of feet, pacing and so on.

Treatment: anticholinergics, propanalol, cyproheptadine, benzodiazepines, or clonidine.

45
Q

What are parkinsons-like symptoms?

A

Bradykinesia
Tremor
Muscular rigidity

Treatment: anticholinergics

46
Q

What is tardive dyskinesia?

A

Involuntary, repetitive, purposeless movements of the tongue, lips, face, trunk, and extremities that may be generalised or affect only certain muscle groups, typically orofacial.

Occurs after several months or years of antipsychotic use. Doesn’t respond well to treatment.

47
Q

What adjunctive or augmentative drugs can you use if clozapine does not work?

A

Benzodiazepines, lithium, or carbamezepine.

48
Q

When should you administer clozapine?

A

After two antipsychotics have been trialled and shown to be inaffective.

49
Q

When would you perform rapid tranquilisation and how do you perform it?

A

The emergency treatment of acute psychosis.

Typical regimen is lorazepam 1mg as required, up to 4mg per 24 hours, delivered either orally or intra-muscularly.

50
Q

What psychosocial interventions are beneficial in schizophrenia?

A
Family education
Self-help groups
CBT
Family therapy
Social and vocational skills training
Sheltered employment
51
Q

What is the prognosis of schizophrenia?

A

Rule of thirds
1/3 will recover and lead normal or almost normal lives
1/3 improve but continue to experience significant symptoms
1/3 do not improve significantly and require frequent hospitalisation

52
Q

How does the life expectancy of someone with schizophrenia compare with general populous?

A

Reduced by about 8-10 years.

53
Q

What are good prognostic factors in schizophrenia?

A
Acute onset
Late onset
Precipitating factors
Florid symptoms or associated mood disorder
Female sex
No family history
No substance misuse
Good premorbid functioning 
Good social support and stimulation
Married
Early treatment and compliance
Good response to treatment
54
Q

What are bad prognostic factors in schizophrenia?

A
Insidious onset
Early onset
No precipitating factors
Negative symptoms
Male sex
Family history
Substance misuse
Poor premorbid functioning
Poor social support and stimulation
Unmarried
Delayed treatment and non-compliance
Poor response to treatment
55
Q

What is an acute or brief psychotic disorder?

A

Brief psychotic disorder looks similar to acute-phase schizophrenia, but is characterised by a rapid, often stress-induced, onset, vivid delusions or hallucinations, a short course of less than one month, and a complete recovery.

56
Q

What is persistent delusional disorder?

A

This condition features a single delusion or set of related delusions, often persecutory, hypochondriacal, or grandiose in content. The delusions are of a fixed, elaborate, and systematised kind, and can often be related to the patients life circumstances.

57
Q

What is schizoaffective disorder?

A

Characterised by prominent affective and schizophrenic symptoms in the same episode of illness. Mood symptoms tend to be episodic rather than continuous.

58
Q

What is schizotypal disorder?

A

Also called latent schizophrenia, characterised by eccentric behaviour and anomalies of thinking and affect similar to those seen in schizophrenia.

First degree relatives of schizophrenia sufferers are at increased are at increased risk.

59
Q

What is late paraphrenia?

A

Late-onset schizophrenia. Typically absent of disorganised, negative or catatonic symptoms.

60
Q

What is induced delusional disorder?

A

A delusional disorder shared by two or more people in a close and dependent relationship. Delusions are usually chronic and either persecutory or grandiose in content.

Folie a Deux, folie a trois, etc.

61
Q

What is the tetrad of neuroleptic malignant syndrome?

A

Hyperthermia, muscle rigidity, autonomic instability, and altered mental status.