9. Heart failure - management Flashcards Preview

ESA 2- Cardiovascular System > 9. Heart failure - management > Flashcards

Flashcards in 9. Heart failure - management Deck (9):
1

Name 5 drugs used to treat HF.

1- ACE inhibitors
2- AngII receptor blockers
3- Diuretics - MRAs (mineralocorticoids/aldosterone R antagonists)
4- B-blockers
5- ARNI (angiotensin R neprilysin inhibitor): valsartan and sacubitril

2

Name 2 drugs used in HF to treat cardiovascular comorbidities.

1. anticoagulants, e.g. low-dose aspirin (75mg/day)
2. statins

3

What is the effect and action of ACE inhibitors?

- Effect: decreased BP by vasodilation and diuresis

- Action: inhibits ACE... prevents conversion of AngI to AngII... prevents activation of RAAS and resulting vasoconstriction and Na+/H2O retention

4

What is the effect and action of AngII receptor blockers?

- Effect: decreased BP by vasodilation and diuresis

- Action: bind to AngII receptors (AT1R)... prevent vasoconstriction and aldosterone-mediated Na+/H2O retention.

5

What is the effect and action of diuretics?

- Effect: decreased BP by diuresis

- Action: antagonise aldosterone by binding at minerlocorticoid receptors... inhibit Na+/H2O retention.

6

What is the effect and action of beta-blockers?

- Effect: decreased BP by vasodilation, and decreased HR and contractility

- Action: bind to B adrenoRs... antagonise NA... prevents SNS activation.

7

What is the effect and action of ARNI?

- Effect: decreased BP by vasodilation and diuresis

- Action:
- VALSARTAN: blocks AT1Rs... antagonises AngII... prevents vasoconstriction and aldosterone-mediated Na+/H2O retention.
- SACUBITRIL: inhibits neprilysin enzyme... prevents degradatoin of vasoactive peptides inc. natriuretic peptides and bradykinin.

8

What is the effect and action of aspirin?

- Effect: anticoagulant to reduce risk of emboli and strokes in IHD

- Action: irreversibly blocks formation of thromboxane A2 in platelets... inhibits platelet aggregation

9

What is the effect and action of statins?

- Effect: decreases cholesterol to reduce effect of coronary artery atherosclerosis in HF

- Action: inhibition of HMG-CoA reductase... inhibits cholesterol synthesis