Flashcards in Cardiology medication Deck (8)
Stops the conversion of angiotensin I to II.
Angiotensin II is a vasoconstrictor and stimulates aldosterone secretion
Start at 1.25mg(HF)/2.5mg titrate up to 10mg
S/E: Cough/ Postural hypotension
Must check renal function after 2/52 weeks due to the nephrotoxic effects
Calcium channel blockers
Decrease Ca2+ entry into the vascular and cardiac cells. Calcium stimulates contraction.
Results in relaxation and vasodilation in the arterial smooth muscle
•Non dihydropyridine: Cardiac contractibility and conduction of the heart
HTN: 5-10mg daily
S/E: Worsening HF, Flushing, oedema, gum hypertrophy
Inhibits the Na/CL co transporter in the DCT of the nephron.
Contraindication in gout
Decrease in sodium and potassium
Blocks the alpha one adrenoreceptor
Doxazosin (Note that Tamsulosin is only licensed for BPH)
S/E: Anxiety, back pain and coughing
Angiotensin II blocker
Block the action of angiotensin II on the AT1 receptor
Losartan / Cadasartan
50mg other conditions
S/E: Vertigo, symptomatic hypertension
Aldosterone is a mineralocorticoid blocker on the mineralocorticoid receptor in the DCT of the kidneys decreasing the activity of the EnaC. Reduces the reabsorption of sodium and water.
25mg for heart failure/ resitant hypertension
S/E: Gyanecomastia, Anxiety, Hypotenison, Hyperkalaemia ( tall tented T waves)
Negatively chronotropic (reduces HR) and positively inotropic (increases force of contraction) Inhibitions of the Na+/K+ atpase pumps causing Na+ to accumulate in the cells. As a result, Ca also accumulates in the cells resulting in a higher contractile force.
Digoxin 125-250mg (maintenance dose)