Flashcards in Obs&Gynae Meds Deck (12)
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1
Tamoxifen
Osterogen receptor antagonist
S/E can cause endometrial changes
ovarian cysts
2
Oxybutynin
Antimuscarinic
Relaxes M2 +M3 of the bladder (detrusor muscles)
PO
S/E; Dry mouth, constipation, blurred vision, nausea and vomiting.
5mg 2-3 daily (immediate release)
3
Mirabegron
Beta-3-adrenergic receptor
Relaxes the detrusor muscles of the bladder
4
Combined oral contraceptive pill (COCP)
Acts on the hypothalamic pituitary axis
- prevents synthesis and stimulation of FSH and LH
- cervical mucus increases
- endometrium is hostile to implantation
S/E: VTE, MI, stroke, breast cancer, cervical cancer
Contraindications: migraine with aura, VTE in hx or family history, vascular disease, smokers >35, BMI>35, diabetes
5
Mini-pill (POP)
cervical mucus becomes impenetrable to the sperm, becomes more viscous
ovulation is inhibited in 60% of the cases
Good alternative to COCP, must be taken every day and at the same time to be effective
S/E: can produce irregular menstruation, increase risk of an ovarian cyst
6
Minerva coil
Suppressant effect on the endometrium (prevents implantation) = endometrial atrophy
Decreases sperm penetration of the cervical mucus
Contraindicated: infections (PID), uterine abnormalities, gynae cancers
7
Depo-provera
Suppress ovulation, makes the endometrium unsuitable for ovulation
Contraindications: current breast cancer, arterial disease, pregnancy, unexplained vaginal bleeding
S/E: irregular bleeding, bone mineral density, CVP, breast cancer, weight gain
8
GnRH analogues
Removes the pusitile nature of GnRH
Bind to the receptors saturating them, flare effect of LH and FSH followed by down regulation
Suppression of LH and FSH
Only for 6 months as can lead to osteoporosis
Eg Goserelin (zoladex)
9
Co-cyprindol
Treatment of PCOS
Treats acne and hirsutism
Anti-androgen (suppresses the androgen blockers)
1 tablet for 21 days on first day of menstrual cycle
10
Elformithine
Treatment of PCOS
Topical cream for the removal of facial hair
11
Clomifene
Inhibits oestrogen receptors in the hypothalamus inhibiting the negative feedback loop of oestrogen on GnHR
50mg OD for 5 days
12
