Cocaine

Question 1

Description

Answer 1

Naturally occurring but purified alkaloid extracted from the coca plant

Question 2

Actions

Answer 2

1. Acts indirectly to block reuptake of NE (also Epi, DA) at the synapse
2. Can stimulate release of NE, Epi, and DA from neurons
3. Acts as local anesthetic and CNS stimulant

Question 3

Indications

Answer 3

Nose bleeds (anesthesia plus vasoconstriction)
Anesthesia for corneal surgery

Question 4

Other Facts

Answer 4

1. CNS stimulation more intense, shorter lasting than amphetamine
2. Side effects hypertension, tachycardia, arrhythmias, seizures, MI
3. Controlled substance -> smoke, snort, inject