Description
Reversible cholinesterase inhibitor
Actions
Indirectly stimulates both nicotinic and muscarinic acetylcholine receptors
Indications
Glaucoma, Alzheimers disease, delayed gastric emptying, anticholinergic toxicity with CNS effects e.g. atropine overdose, nondepolarizing neuromuscular blockade reversal
Toxicity
Cholinergic reaction (DUMBBELSS)
Other Facts
Crosses the BBB so not used for myasthenia gravis (uncharged and lipid soluble), IV / IM