Endocrine Disruptors Flashcards

1
Q

What are the hormones secreted by the kidney?

A

Renin
Erythropoietin
Vitamin D

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2
Q

What are the hormones of the heart?

A

ANP

BNP

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3
Q

What are the hormones of the liver?

A

IGF-I

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4
Q

What are the hormones of the GI tract?

A

Serotonin

Ghrelin

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5
Q

What are some of the non-classical endocrine glands?

A
Brain
Kidney
Heart
Liver
GI
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6
Q

Where is renin made?

A

In the juxtoglomerluar cells of afferent arterioles in the kidney

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7
Q

What is the function of renin?

A

Regulation of the arteriolar diameter

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8
Q

What is the molecular action of renin?

A

Cleaves angiotensinogen to angiotensin I -> precursor for angiotensin II

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9
Q

What is the function of erythropoietin?

A

Stimulates proerythroblasts and differentiation of red blood cells (increases cell number)

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10
Q

What are some regulators of EPO?

A
Anemia
Hypoxia
Thyroid Hormone
NE
Androgens
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11
Q

What is the major side effect of blood doping?

A

Hypertension

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12
Q

What is the function of ANP/BNP?

A

They will decrease the overall blood volume by increasing the rate of water and Na excretion. It also relaxes the blood vessels

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13
Q

What is the effect of ANP/BNP on the hematocrit?

A

It will increase it due to the decrease in blood volume

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14
Q

What can normal levels of BNP rule out?

A

CHF

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15
Q

What are endocrine disruptors?

A

Any chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife

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16
Q

How do PCBs act as endocrine disruptors?

A

PCBs compete with thyroid hormone binding to its transport protein in the blood (TTR; TBG) which will increase the breakdown of thyroid hormone in the blood and result in excessive thyroid hormone production and a goiter.

17
Q

How does Diethylstilbestrol (DES) act as an endocrine disruptor?

A

Non-steroidal synthetic estrogen used in cattle feed that can mimic the effects of estrogen.