Enoxaparin

Question 1

what is it and mechanism

Answer 1

Low Molecular Weight Heparin

prevents fibrinogen conversion into fibrin-> prevents coagulation cascade

Question 2

indications

Answer 2

prophylaxis of DVT/ PE- especially in surgical patients or acutely unwell

treatment of DVT in pregnant women (DOACs contraindicated)

treatment of DVT in people that are at low risk of recurrence

can be given in MI when undergoing a Primary PCI

Question 3

contraindications

Answer 3

History of heparin- induced thrombocytopenia (low platelets)

clinically significant bleeding e.g. peptic ulcer

Question 4

interactions

Answer 4

thrombolytics e.g. TPA

NSAIDs e.g. aspirin

systemic glucocorticoids e.g prednisolone

Question 5

side effects

Answer 5

increase in liver enzymes

haemorrhage
thrombocytopenia
allergic reaction
headache
urticaria (hives) and associated pruritus