Furosemide

Question 1

what is it and mechanism

Answer 1

loop diuretic

decrease Na reabsorption in ascending LofH
so less Na+ in interstitium so water doesn’t move out of collecting duct
so excrete more urine

Question 2

indications

Answer 2

oedema

CHF
cirrhosis
renal disease e.g. nephrotic syndrome
orally in mild hypertension
pulmonary oedema

Question 3

contraindications

Answer 3

anuria
comatose
renal failure
sever hypokalaemia/ hyponatraemia

Question 4

interactions

Answer 4

antiarrythmics e.g. amiodarone, digoxin

targeted cancer drugs e.g. carbozantinib

SSRIs e.g. citalopram

macrolide antibiotics e.g. clarithromycin

antifungals e.g. fluconazole

Question 5

side effects

Answer 5

polyuria
polydipsia
headache
confused/ dizzy
nausea
tachycardia

Question 6

name a type of thiazide diuretic (not loop)

Answer 6

bendroflumethiazide