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Flashcards in exam 1 Deck (22):
1

suculfan

classic alkylator

2

chlorambucil

classic alkylator

3

cyclophosphamide

classic alkylator

4

ifosfamide

classic alkylator

5

mechlorethamine

classic alkylator

6

melphalan

classic alkylator

7

thiotepa

classic alkylator

8

carmuctine

nitrosureas alkylator

9

lomuctine

nitrosureas alkylator

10

streptozooin

nitrosureas alkylator

11

altreramine

alkylator-like

12

carboplatin

alkylator-like; platinum agent

13

cisplatin

alkylator-like; platinum agent

14

dacarbazine

alkylator-like

15

prooarbazine

alkylator-like

16

preferred sites of DNA alkylation

N-7 guanine, N-2 guanine, O-6 guanine, O-4 thymine

17

monofunctional agents

dacarbazine, procarbazine, temozolomide

18

bifunctional agents

N2 mustards, cyclophosphamide, nitrosureas, melphalan

19

least toxic of the nitrogen mustard agents

chlorambucil

20

drugs of choice for brain tumors

nitrosureas

21

drug of choice for palliative treatment of chronic myelogenous leukemia (CML)

busulfan

22

major side effects of alkylating agents

hematopoietic toxicity, gastrointestinal toxicity, gonadal toxicity, oulmonary toxicity, alopecia, teratogenicity, carcinogenesis, immunosuppression