exam 1

Question 1

suculfan

Answer 1

classic alkylator

Question 2

chlorambucil

Answer 2

classic alkylator

Question 3

cyclophosphamide

Answer 3

classic alkylator

Question 4

ifosfamide

Answer 4

classic alkylator

Question 5

mechlorethamine

Answer 5

classic alkylator

Question 6

melphalan

Answer 6

classic alkylator

Question 7

thiotepa

Answer 7

classic alkylator

Question 8

carmuctine

Answer 8

nitrosureas alkylator

Question 9

lomuctine

Answer 9

nitrosureas alkylator

Question 10

streptozooin

Answer 10

nitrosureas alkylator

Question 11

altreramine

Answer 11

alkylator-like

Question 12

carboplatin

Answer 12

alkylator-like; platinum agent

Question 13

cisplatin

Answer 13

alkylator-like; platinum agent

Question 14

dacarbazine

Answer 14

alkylator-like

Question 15

prooarbazine

Answer 15

alkylator-like

Question 16

preferred sites of DNA alkylation

Answer 16

N-7 guanine, N-2 guanine, O-6 guanine, O-4 thymine

Question 17

monofunctional agents

Answer 17

dacarbazine, procarbazine, temozolomide

Question 18

bifunctional agents

Answer 18

N2 mustards, cyclophosphamide, nitrosureas, melphalan

Question 19

least toxic of the nitrogen mustard agents

Answer 19

chlorambucil

Question 20

drugs of choice for brain tumors

Answer 20

nitrosureas

Question 21

drug of choice for palliative treatment of chronic myelogenous leukemia (CML)

Answer 21

busulfan

Question 22

major side effects of alkylating agents

Answer 22

hematopoietic toxicity, gastrointestinal toxicity, gonadal toxicity, oulmonary toxicity, alopecia, teratogenicity, carcinogenesis, immunosuppression