Flashcards in exam 1 Deck (22):
1
suculfan
classic alkylator
2
chlorambucil
classic alkylator
3
cyclophosphamide
classic alkylator
4
ifosfamide
classic alkylator
5
mechlorethamine
classic alkylator
6
melphalan
classic alkylator
7
thiotepa
classic alkylator
8
carmuctine
nitrosureas alkylator
9
lomuctine
nitrosureas alkylator
10
streptozooin
nitrosureas alkylator
11
altreramine
alkylator-like
12
carboplatin
alkylator-like; platinum agent
13
cisplatin
alkylator-like; platinum agent
14
dacarbazine
alkylator-like
15
prooarbazine
alkylator-like
16
preferred sites of DNA alkylation
N-7 guanine, N-2 guanine, O-6 guanine, O-4 thymine
17
monofunctional agents
dacarbazine, procarbazine, temozolomide
18
bifunctional agents
N2 mustards, cyclophosphamide, nitrosureas, melphalan
19
least toxic of the nitrogen mustard agents
chlorambucil
20
drugs of choice for brain tumors
nitrosureas
21
drug of choice for palliative treatment of chronic myelogenous leukemia (CML)
busulfan
22