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Flashcards in Exam2 Deck (125)
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1

Where do T Cells mature?

Thymus

2

What are the "antibody-like" receptors found on T Cell surface?

T Cell Receptor (TCR)

3

What MHC do killer T cells scan?

MHC 1 presented by all cells

4

MHC 2 are scanned by what cells?

Helper T cells

5

Helper T Cells secrete what 2 cytokines?

IL-2, INF-gamma

6

What are the three antigen presenting cells that helper t cells need for activation?

Dendritic cells, Macrophages, B Cells

7

What happens if the TCR recognizes the cognate antigen on MHC but isn't co-stimulated?

The T-Cell is anergized (inactivated)

8

T/F: There are thousands of different TCR's on a given mature T-Cell

False: all TCR on a given T Cell are identical

9

What are the two types of TCR?

alpha-beta (traditional and most common)
gamma-delta (non-traditional)

10

Where are T-cells with gamma-delta TCR most common?

Intestine, uterus, tongue

11

What is the co-stimulatory molecule found on the T-Cell?

CD28

12

What does the CD28 on a T-Cell bind to?

B7 molecule on APC

13

What is the group of proteins needed for signaling?

CD3 Proteins

14

T/F: CD8 is the co receptor found on killer T-cells

True

15

What is the function of cholesterol lipid rafts?

Contain large # of signaling molecules, making signaling process easier

16

T/F: Naïve T-cells have more lipid rafts

False: more experience=more rafts

17

How many dendritic cells does one helper t-cell scan per hour?

1000 dendritic cells

18

What does the CD40L and CD40 binding lead to?

Lengthens the life of the dendritic cell involved

19

How long does the complete activation of a helper T-cell take?

4-10 hours

20

What receptor is absent from naïve T-cell surface?

IL-2

21

What are the two jobs of T-helper cell?

1) Stay in blood/lymph to help B-Cells and Killer T Cells
2) Enter battle sites to help reactivate other cells there

22

What do T-helpers secrete as a form of help?

Cytokines

23

What are the three major types of T-helper cells?

Th1, Th2, Th17

24

TLR4 recognizes which 2 pathogens?

Gram-negative bacteria, viruses

25

TLR3 recognizes what?

double stranded RNA

26

Gram-positive bacteria are recognized by what toll-like-receptor?

TLR2

27

Th1 Helper T Cells are needed in what kind of attack?

Th1=viral or bacterial attack

28

T/F: Th2 Helper T Cells are needed in parasitic attacks

True: Th2=parasitic/food-borne bacteria

29

What are the classical cytokines put off by Th1?

TNF, INF-gamma, IL2

30

What cytokines are put off in a parasitic attack?

IL-4, IL-5, IL-13