Heme/Onco I Flashcards Preview

Board Review - C - Heme/Oncology > Heme/Onco I > Flashcards

Flashcards in Heme/Onco I Deck (38)
1

anisocytosis

variable size

2

poikilcytosis

variable shape

3

RBC membrane

Cl/HCO3 antiport

export HCO3 and transport CO2 from periphery to lungs

4

GpIIb/IIIa

fibrinogen receptor

5

platelet granules

dense - ADP and Ca
a- vWF and fibrinogen

6

band cells

immature neutro

7

polysegmented neutro

B12/folate deficiency

8

chemotaxis of neutrophils

C5a
IL-8
LTB4
kallikrein
PAF

9

lipid A

from LPS

bind CD14 on macros - septic shock

10

macrophage activation

IFN-gamma

can present MHC II - antigen presentation

11

major basic protein

from eosinophil

defense against helminth

12

basophil content

heparin
histamine

13

mast cell

bind Fc of IgE
release histamine, heparin, eosinophil chemotactic factors

14

dendritic cell

APC

MHC class II

15

lymphocyte

B cell
T cells
NK cells

16

CD28

for T cell activation

17

cross placenta

IgG

18

universal blood donor

O group

19

universal blood recipient

AB group

20

Rh incompatible

Rh - mother - make anti-D IgG - cross placenta

hemolytic disease of newborn (erythroblastosis fetalis)

tx - rhogam

Rh = D

21

plasma Abs for A and B blood groups

IgM

22

extrinsic coag

tissue factor to factor VII

23

intrinsic pathway

collagen to factor XII

also - activated by HMWK - kinin cascade

24

epoxide reductase

reduces vitamin K - to active clot factors

25

factor V leidein mutation

factor V resistant to inhibition by protein C

26

source of vWF

endothelial cell - wiebel paladie body
platelet - a-granules

27

platelet binding

release Ca and ADP, and TXA2

ADP - induces GpIIb/IIIa on platelet surface

28

aspirin

inhiit COX

inhibit TXA2

29

ristocetin

vWF binding Gp1b

diagnosis of vWD and BS syndrome

30

inhibit GpIIb/IIIa

abciximab
eptifibatide
tirofiban

31

acanthocyte

spur cell

32

ringed sideroblast

sideroblast anemia

excess iron in mito

33

schistocyte

helmet cell

with hemolysis mechanical

CID, TTP/HUS, HHELLP, heart valve

34

sickling

with dehydration, deoxygenation, and high altitude

35

dacrocyte

teardrop shaped

bone marrow infiltration

36

target disease

HbC disease
asplenia
liver
thalassemia

37

heniz body

oxidation of Hb SH group to disulfide bond

precipitate

phagocytosed - bite cells

with G6PD deficiency

38

howel jolly bodies

nuclear remnants in RBCs

normal removed by splenic

indicate hyposplenia or asplenia