Heme/Onco IV Flashcards Preview

Board Review - C - Heme/Oncology > Heme/Onco IV > Flashcards

Flashcards in Heme/Onco IV Deck (37)
1

leukemia vs. lymphoma

leukemia - bone marrow involvement
-cells in peripheral blood

lymphoma - lymph node

2

leukemoid rxn

inflammatory response to infection

WBC elevated with neutro and band cells - left shift

increased leukocyte alk phos

3

leukemoid rxn vs. CML

WBC elevated with band cells - left shift - in both

CML - no LAP
LR - elevated LAP - leukocyte alk phos

4

hodgkin lymphoma

local group nodes

prognosis - stage - better than NHL

reed sternberg cells

bimodal distribution

EBV association

5

non-hodgkin lymphoma

multiple peripheral nodes
extranodal involvement

majority B cells

incidence peak 20-40yo

HIV and autoimmune association

6

reed stern berg cells

owl eyes

hodgkin lymphoma

CD15 and CD30 positive

better prognosis - stromal or lymph rxn to RS cells
-lympho rich - best prognosis

7

burkitt lymphoma

t (8;14)
c-myc on 8 with heavy chain (14)
starry scar

endemic - jaw - african

associated with EBV

8

diffuse large B cell lymphoma

older adults

MC type NHL in adults

9

follicular lymphoma

t (14;18)
BCL2 and heavy chain

Bcl2 inhibit apoptosis

wax and wain painless lymphadenopathy

10

mantle cell lymphoma

older males

t (11;14)
translocation cyclin D1 with heavy chain

CD5 positive

11

sezary syndrome

mycosis fungoides

skin patch and plaque

cutaneous T cell lymphoma

atypical CD4 cells - cerebriform nuclei

12

multiple myeloma

plasma cell - fried egg
-clock face

lots of IgG

AL - primary amyloid

punched out bone lesion

M spike

Ig light chain - bence jones proteinuria

rouleaux formation

13

monoclonal gammopathy of undetermined significance

MGUS

monoclonal expansion of plasma cells

develop multiple myeloma at rate of 1-2% per year

14

waldenstrom macroglobulinemia

M spike - IgM - vs. IgG (MM)

hyperviscous syndrome

blurry vision
raynauds

15

pseudo pelger huet anomaly

neutrophil with bilobed nuclei

after chemo

16

T cell ALL

mediastinal mass

with dow syndrome

17

TdT

marker pre T and B cells

18

CD10

only pre-B cell

19

t(12;21)

better prognosis for ALL

20

CLL

elderly

MC adult leukemia

CD20 and CD5 positive - B cells

smudge cells

21

SLL - small lymphocytic leukemia

same as CLL

but CLL - higher peripheral blood lymphomcytosis

22

hairy cell leukemia

mature B cell tumor in elderly

dry tap on aspiration

TRAP positive

23

tartrate resistant acid phosphatase

TRAP

positive in hairy cell leukemia

24

tx hairy cell leukemia

cladribine
pentostatin

25

AML

65yo
auer rod - M3 subtype

increased myeloblasts on peripheral smear
-

26

t(15;17)

M3 AML

all trans retinoic acid - vit A

induce differentiation of myeloblasts

27

CML

t (9;22)
BCR-ABL fusion - philly

blast crisis

splenomegaly

low LAP - low activity mature granulocytes

28

imatinib

tx of CML

BCR-ABL tyrosine kinase inhibitor

29

all-trans retinoic acid

tx of M3 AML

t (15;17)

30

langerhans cell histiocytosis

disorder of dendrites

lytic bone lesion - in child

birbeck granule
S-100 positive - mesodermal origin
CD1a

31

JAK2 mutation

hematopoietic growth factor signaling

mutation in chronic myeloproliferative disorders (not CML)

32

polycythemia vera

increased hematocrit

JAK2 mutation

itching after shower

secondary - due to EPO level increase

33

essential thrombocytosis

overproduction of platelets - abnormal

bleeding and thrombosis

bone marrow - large megakaryocytes

34

myelofibrosis

obliteration of bone marrow
-fibroblast activity

teardrop RBCs - and dry tap

35

relative polycythemia

dehydration and burn - decreased plasma volume

36

appropriate absolute polycythemia

lung disease
heart disease
high altitude

see more RBC with low O2 sat and elevated EPO

37

inappropriate absolute polycythemia

see more RBC and no decreased O2 sat

and elevated EPO

renal cell carcinoma
hepatocellular carcinoma
hydronephrosis

ectopic EPO