insulin resistence

Question 1

what can cause insulin resistence?

Answer 1

• excess weight
• excess calorie intake
• sedentary lifestyle
• genetics

Question 2

True or False

There is defective insulin signallin in Alzheimers

Answer 2

True

Question 3

what are the mechanisms of insulin resistence?

Answer 3

• impairment of insulin signalling (e.g. skeletal muscle insulin resistance)
• inflammation (e.g. adipose tissue insulin resistence)
• pathway selective hepatic insulin resistance

Question 4

what is the gold standard for the measurement of insulin sensitivty?

Answer 4

-hyperinsulinemic euglycemic clamp

Question 5

how can obesity/high fat diet cause insulin resistace through inflammation?

Answer 5

• obesity/high fat diet can lead to inflammation
• inflammation increases collagen, HA etc
• this causes an increase in ECM (extracellular matrix )receptor signalling
• increases in ECM receptor signalling causes muscle insulin resistence

Question 6

can insulin resistance be reversed?

Answer 6

yes as long as you eat less, move more and take medication