Intro to Neuro anesthesia PPt-josh Flashcards Preview

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Flashcards in Intro to Neuro anesthesia PPt-josh Deck (139)
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1

The adult brain weighs about ______or 2% of tbw

 

 

1350gm

 

 

2

CBF is how much

(not a single number but _-_/__/__)

45-55 mL/100g/min

Avg is 50mL/100g/min

3

What is the avg CBF ml/min

750mL/min

4

What is the equation for CBF

CBF= CPP/CVR

5

the brain receives what % of CO

12-15%

6

 

CMRO2 is what % of O2 consumption

20%

7

What is avg CMRO2

(__/__/__)

3.5mL/100g/min

8

what is equation for CPP

CPP= MAP-ICP (or CVP which ever is more)

9

what happens to CMRO2 during sleep

decreases

10

 

CBF decreases ___% for every __C decrease in body temp below 37C

7%

1C

11

what do VAA do to CMRO2?

decrease it

12

what is autoregulation

MAP 60-160mmHg

(or her slide says 70-150 mmHg)

13


Autoregulation of CBF is know as what type of regulation?

Myogenic regulation

14

Rapid changes in MAP can result in transient periods of Altered _____ (probally no more than 3-4 min)

CBF

15

what are the 2 types of regulation for CBF?

  1. Myogenic
  2. Neurogenic

16

Myogenic regulation on CBF is thought to occur why?

b/c of the autoregulation and rapid changes in MAP in transiet periods of altered CBF, probaly occurs d/t direct muscle changes in the tone of vascular smooth muscle

17

the Neurogenic regulation of CBF has its greatest neurogenic effect on the larger cerebral arteries. what is the most important determinant?

viscosity (HCT)

18

the CNS is derived form what 2 primary cells?

  • Neurons
  • Neuroglial cells

19

what are the 5 neuroglial cells?

 

  1. astrocytes
  2. Ependymal cells
  3. Microglia
  4. Olgodendrocytes
  5. Schwann cells

 

(All Ethipoians Munch On Snails)

20

Neuroglial cells: Functions

Astrocytes

  • Support
  • metobolic
  • nutritive functions

21

Neuroglial cells: Functions

Ependymal Cells

  • lines cavities in teh CNS and make up walls of ventricles

 

22

Neuroglial cells: Functions

Microglia

Phagocytosis

 

23

Neuroglial cells: Functions

Oligodendrocytes

insulation for axons in teh CNS (myelin sheath in brain and spinal cord)

24


Neuroglial cells: Functions

Schwann Cells

  • Insulation-myelin sheath in peripheral nervous system

(Schwann in your arms)

25

Blood Brain Barrier: BBB

it is for effective _______ of the brain and spinal cord

Insolation

26

Blood Brain Barrier: BBB

________ Cells of the CNS form tight junctions b/t cells.

Endothelial cells

27

Blood Brain Barrier: BBB

what is the function of the endothelial cells of the CNS that form tight junctions b/t cells?

to prevent intracellular transfer

28

Blood Brain Barrier: BBB

Midline structures receive neurosecretory products from blood and exist OUTSIDE the BBB (AKA not protected by BB) what are the 5 parts of the brain not protected by teh BBB?

  • Area of Postrema
  • Pituitary gland
  • Pineal gland
  • Choroid plexus
  • portions of the hypothalamus

29

VAA's effect on CBF:

VAA's during normocapnia @ > 0.5 MAC do what  3 things? and all this results in what?

  • Dose related suppression on Cerebral Metabolism
  • Vasodilation d/t direct effects on vascular smooth muscle
  • CBF/CMRO2 ratio altered

** results in*** increases in CBF

 

30

VAA's effect on CBF:

in recap all VAAs greater than 0.5 MAC cause what?

increases in CBF