Neuromuscular Junction PPT-Josh Flashcards Preview

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Flashcards in Neuromuscular Junction PPT-Josh Deck (84)
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1

What is the function of the neuromuscular junction?

 

to conduct propagated impulses to the muscle cell

 

2

Definitions for following cards

NM=Neuromuscular

NDMR= non-depolerizing muscle relaxant

DMR= depolarizing muscle relaxant

thats for you dwayne

3

Motor end plate Potential:

how many protein sub-units are there?

5

4

Motor end plate Potential:

what are the 5 sub units

  • 2 alpha
  • beta
  • delta
  • gamma

5

Motor end plate Potential:

ACh binds to what subunit? and how many of the subunits? to open to ion channels

  • aplha
  • 2

6

Motor end plate Potential:

what the ACh binds to the 2 alpha subunits and opens the ion channels, what ions are exchanged?

  • k+ out
  • Na+ and Ca+ in

7

Muscle Relaxants:

which type produce NO fade on TOF

DMR

(SCh)

8

Muscle Relaxants:

basically all SCh is, is the combination of what 2 molecules?

  • 2 ACh's

9

Muscle Relaxants:

what type produces fade on TOF

NDMR

10

Nerve Stimulation/ Monitoring:

what is the purpose of it?

 

 

To evaluate degree of muscle paralysis or recovery from paralysis

 

11

SAY WHAT % OF RECEPTORS ARE STILL BLOCKED

Normal Tv

 

80%

12

SAY WHAT % OF RECEPTORS ARE STILL BLOCKED

Holds tetanus 50Hz

75-80%

13

SAY WHAT % OF RECEPTORS ARE STILL BLOCKED

TOF, DBS

75-80%

14

SAY WHAT % OF RECEPTORS ARE STILL BLOCKED

Holds tetanus 100Hz

50%

15

SAY WHAT % OF RECEPTORS ARE STILL BLOCKED

Head lift x 5 sec.s

33%

16

Myasthenia Gravis (MG):

the alteration is where?

Post-juntional

17

Myasthenia Gravis (MG):

there is an autoimmune response to ACh receptors.so what happens to their receptors?

Decrease #

18

Myasthenia Gravis (MG):

the onset is usually presents w/ what signs?

Pharyngeal and ocular weakness

19

Myasthenia Gravis (MG):

what happens with exercise? worse or better?

worse

20

Myasthenia Gravis (MG):

treatment?

Anticholinesterases (edrophonium)

21

Myasthenia Gravis (MG):

undertreatment causes what?

Myasthenic crisis (weakness)

22

Myasthenia Gravis (MG):

what occurs w/ SCh

resistance (Slight)

23

Myasthenia Gravis (MG):

what happens w/ NDMR

 

Sensitive (very)

 

24

Cholinergic Crisis:

is due to what?

An excess administration of Anticholenesterase drugs (usually pyridastigmine)

25

 

Cholinergic Crisis:

S/S

Increaseing weakness

muscarinic affects

(SLUDGE)

Salivation

Lacrimation

Urination

Defication

Gastric upset

Emesis

(add miosis)

 

26

Myastenic crisis vs Cholinergic Crisis:

How can you differentiate b/t the 2

  • Give edrophonium 1-10 mgIV
  • Improves= Myasthenic crisis
  • Worsens= Cholinergic crisis

** makes sense Myasthenis crisis- the onder streament so it would help, cholinergic crisis too much anticholinesterase thus more would make it worse**

27

Myasthenic Syndrome/ Eaton Lambert Syndrome:

where is the alteration in the junction

Pre-juntional

28

Myasthenic Syndrome/ Eaton Lambert Syndrome:

what is the main problem r/t ACh or ACh recptors?

Decreased ACh release

29

Myasthenic Syndrome/ Eaton Lambert Syndrome:

usually associated w/ underlying malignancy. what is that malignancy?

Oat cell Ca

30


Myasthenic Syndrome/ Eaton Lambert Syndrome:

What muscles are usually affected

peripheral and pelvic